1. Molecular interactions between dietary lipids and bone tissue during aging
- Author
-
Tamara Y. Forbes-Hernandez, Lorena Madrigal, Maurizio Battino, José L. Quiles, José M. Romero-Márquez, Irma Domínguez, María D. Navarro-Hortal, Alberto Badillo-Carrasco, Alfonso Varela-López, and Francesca Giampieri
- Subjects
0301 basic medicine ,Aging ,Osteoporosis ,Osteoarthritis ,Disease ,Review ,Bone tissue ,Bone remodeling ,0302 clinical medicine ,Saturated fat diet ,Biology (General) ,Spectroscopy ,Osteitis ,Dietary lipids ,Molecular interactions ,education.field_of_study ,General Medicine ,Computer Science Applications ,Chemistry ,medicine.anatomical_structure ,saturated fat diet ,Bone Remodeling ,medicine.medical_specialty ,QH301-705.5 ,Population ,hallmarks of aging ,030209 endocrinology & metabolism ,Catalysis ,dietary lipids ,Bone and Bones ,Genomic Instability ,Inorganic Chemistry ,03 medical and health sciences ,medicine ,Autophagy ,Animals ,Humans ,Physical and Theoretical Chemistry ,Intensive care medicine ,education ,Molecular Biology ,QD1-999 ,Hallmarks of aging ,business.industry ,6108.03 Senectud ,Public health ,Organic Chemistry ,medicine.disease ,Dietary Fats ,Hormones ,Diet ,Oxidative Stress ,030104 developmental biology ,Oxidative stress ,2302.18 Lípidos ,business ,3206 Ciencias de la Nutrición ,Biomarkers - Abstract
M.D.N.-H. and J.M.R.-M. are recipient of a FPU fellow from the Spanish Ministry of Educación y Formación Profesional., Age-related bone disorders such as osteoporosis or osteoarthritis are a major public health problem due to the functional disability for millions of people worldwide. Furthermore, fractures are associated with a higher degree of morbidity and mortality in the long term, which generates greater financial and health costs. As the world population becomes older, the incidence of this type of disease increases and this effect seems notably greater in those countries that present a more westernized lifestyle. Thus, increased efforts are directed toward reducing risks that need to focus not only on the prevention of bone diseases, but also on the treatment of persons already afflicted. Evidence is accumulating that dietary lipids play an important role in bone health which results relevant to develop effective interventions for prevent bone diseases or alterations, especially in the elderly segment of the population. This review focuses on evidence about the effects of dietary lipids on bone health and describes possible mechanisms to explain how lipids act on bone metabolism during aging. Little work, however, has been accomplished in humans, so this is a challenge for future research.
- Published
- 2021