1. Successful treatment of invasive aspergillosis caused by Aspergillus parafelis in a kidney transplant recipient
- Author
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Eugenio Garduño-Eseverri, Rocío Martínez-Gallardo, R. Hernández-Gallego, Antonia Calvo-Cano, F.F. Rodríguez-Vidigal, and Ana Alastruey-Izquierdo
- Subjects
0301 basic medicine ,Antifungal ,medicine.medical_specialty ,medicine.drug_class ,030106 microbiology ,030231 tropical medicine ,Case Report ,Aspergillosis ,Microbiology ,Aspergillus fumigatus ,03 medical and health sciences ,0302 clinical medicine ,Azole-resistant aspergillosis ,Internal medicine ,medicine ,Kidney transplant ,lcsh:QH301-705.5 ,Molecular identification ,lcsh:R5-920 ,Aspergillus ,biology ,business.industry ,Mortality rate ,Surgical procedures ,medicine.disease ,biology.organism_classification ,Kidney transplant recipient ,Infectious Diseases ,lcsh:Biology (General) ,Aspergillus parafelis ,Invasive aspergillosis ,lcsh:Medicine (General) ,business - Abstract
Invasive aspergillosis (IA) is associated with a high mortality rate in kidney-transplant recipients. Azole-resistance is increasing in Aspergillus fumigatus. We report a clinical case of a kidney-transplant recipient with cerebellar and pulmonary aspergillosis caused by azole-resistant Aspergillus parafelis (molecular identification through β-tubulin sequence). The patient experienced an effective resolution after three surgical procedures and associated antifungal therapy. This case highlights that azole-resistant aspergillosis should be considered in every patient with IA as long as susceptibility testing results are not known. Therefore, in selected patients with IA and central nervous system involvement, empirical combination antifungal therapy could be considered. Sí
- Published
- 2020
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