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1. The Italian multiple sclerosis register

Author

Trojano, M, Bergamaschi, R, Amato, Mp, Comi, G, Ghezzi, A, Lepore, V, 7, Marrosu, Mg, Mosconi, P, Patti, F, Ponzio, M, Zaratin, P, Battaglia, Ma1, Acquistapace D, Italian Multiple Sclerosis Register Centers Group., Aguglia, U, Annunziata, P, Ardito, B, Avolio, C, Balgera, R, Bandini, F, Banfi, P, Barone, P, Bellantonio, P, Bertolotto, A, Bertora, P, Bombardi, R, Bosco Zimatore, G, Bossio, Rb, Bramanti, P, Brescia Morra, V, Brioschi, Am, Bruzzone, M, Buccafusca, M, Busillo, V, Caneve, G, Caniatti, Lm, Capone, L, Capone, F, Cappellani, A, Cargnelutti, D, Cavaletti, G, Cavalla, P, Celani, Mg, Centonze, D, Chiveri, L, Clerici, R, Clerico, M, Cocco, E, Comi, C, Coniglio, Mg, Cordera, S, Corea, F, Cortese, A, Costantino, G, Cottone, S, Crociani, P, D'Andrea, F, Danni, Mc, De Luca, G, de Pascalis, D, De Robertis, F, De Stefano, N, Di Battista, G, Di Napoli, M, Falcini, M, Fausto, F, Ferrò, Mt, Florio, C, Fortunato, M, Frittelli, C, Galgani, S, Gallo, P, Gatto, M, Gazzola, P, Geda, C, Giordano, A, Granella, F, Grasso, Mg, Grimaldi, Lme, Imperiale, D, Lo Russo, L, Logullo, Fo, Lugaresi, A, Lus, G, Maccarrone, G, Maimone, D, Malagù, S, Marconi, R, Maritato, P, Massacesi, L, Mazzoni, M, Meucci, G, Mirabella, M, Montepietra, S, Nasuelli, D, Neri, W, Orefice, G, Parodi, S, Pasquali, L, Passarella, B, Peresson, M, Perla, F, Pesci, I, Piantadosi, C, Piras, Ml, Pizio, Nr, Pozzilli, C, Protti, A, Pugliatti, M, Quatrale, R, Ragno, M, Rezzonico, M, Ribizzi, G, Riva, M, Ronzoni, M, Rosso, Mg, Rottoli, M, Rovaris, M, Salemi, G, Salvetti, M, Santangelo, M, Santangelo, G, Santuccio, G, Sarchielli, P, Scarpini, E, Sechi, Gp, Severi, S, Sinisi, L, Sola, P, Spitaleri, D, Tassinari, T, Tedeschi, G, Tonietti, S, Torri Clerici, V, Totaro, R, Traccis, S, Turla, M, Uccelli, A, Ulivelli, M, Valentino, P, Valeriani, M, Venturi, S, Vianello, M, Zaffaroni, M., Trojano M., Bergamaschi R., Amato M.P., Comi G., Ghezzi A., Lepore V., Marrosu M.G., Mosconi P., Patti F., Ponzio M., Zaratin P., Battaglia M.A., Acquistapace D., Aguglia U., Annunziata P., Ardito B., Avolio C., Balgera R., Bandini F., Banfi P., Barone P., Bellantonio P., Bertolotto A., Bertora P., Bombardi R., Bosco Zimatore G., Bossio R.B., Bramanti P., Brescia Morra V., Brioschi A.M., Bruzzone M., Buccafusca M., Busillo V., Caneve G., Caniatti L.M., Capone L., Capone F., Cappellani A., Cargnelutti D., Cavaletti G., Cavalla P., Celani M.G., Centonze D., Chiveri L., Clerici R., Clerico M., Cocco E., Comi C., Coniglio M.G., Cordera S., Corea F., Cortese A., Costantino G., Cottone S., Crociani P., D'Andrea F., Danni M.C., De Luca G., de Pascalis D., De Robertis F., De Stefano N., Di Battista G., Di Napoli M., Falcini M., Fausto F., Ferro M.T., Florio C., Fortunato M., Frittelli C., Galgani S., Gallo P., Gatto M., Gazzola P., Geda C., Giordano A., Granella F., Grasso M.G., Grimaldi L.M.E., Imperiale D., Lo Russo L., Logullo F.O., Lugaresi A., Lus G., Maccarrone G., Maimone D., Malagu S., Marconi R., Maritato P., Massacesi L., Mazzoni M., Meucci G., Mirabella M., Montepietra S., Nasuelli D., Neri W., Orefice G., Parodi S., Pasquali L., Passarella B., Peresson M., Perla F., Pesci I., Piantadosi C., Piras M.L., Pizio N.R., Pozzilli C., Protti A., Pugliatti M., Quatrale R., Ragno M., Rezzonico M., Ribizzi G., Riva M., Ronzoni M., Rosso M.G., Rottoli M., Rovaris M., Salemi G., Salvetti M., Santangelo M., Santangelo G., Santuccio G., Sarchielli P., Scarpini E., Sechi G.P., Severi S., Sinisi L., Sola P., Spitaleri D., Tassinari T., Tedeschi G., Tonietti S., Torri Clerici V., Totaro R., Traccis S., Turla M., Uccelli A., Ulivelli M., Valentino P., Valeriani M., Venturi S., Vianello M., Zaffaroni M., Trojano M, Bergamaschi R, Amato M.P, Comi G, Ghezzi A, Lepore V, Marrosu M.G, Mosconi P, Patti F, Ponzio M, Zaratin P, Battaglia M.A, Acquistapace D., Aguglia U., Annunziata P., Ardito B., Avolio C., Balgera R., Bandini F., Banfi P., Barone P., Bellantonio P., Bertolotto A., Bertora P., Bombardi R., Bosco Zimatore G., Bossio R.B., Bramanti P., Brescia Morra V., Brioschi A.M., Bruzzone M., Buccafusca M., Busillo V., Caneve G., Caniatti L.M., Capone L., Capone F., Cappellani A., Cargnelutti D., Cavaletti G., Cavalla P., Celani M.G., Centonze D., Chiveri L., Clerici R., Clerico M., Cocco E., Comi C., Coniglio M.G., Cordera S., Corea F., Cortese A., Costantino G., Cottone S., Crociani P., D’Andrea F., Danni M.C., De Luca G., de Pascalis D., De Robertis F., De Stefano N., Di Battista G., Di Napoli M., Falcini M., Fausto F., Ferrò M.T., Florio C., Fortunato M., Frittelli C., Galgani S., Gallo P., Gatto M., Gazzola P., Geda C., Giordano A., Granella F., Grasso M.G., Grimaldi L.M.E., Imperiale D., Lo Russo L., Logullo F.O., Lugaresi A., Lus G., Maccarrone G., Maimone D., Malagù S., Marconi R., Maritato P., Massacesi L., Mazzoni M., Meucci G., Mirabella M., Montepietra S., Nasuelli D., Neri W., Orefice G., Parodi S., Pasquali L., Passarella B., Peresson M., Perla F., Pesci I., Piantadosi C., Piras M.L., Pizio N.R., Pozzilli C., Protti A., Pugliatti M., Quatrale R., Ragno M., Rezzonico M., Ribizzi G., Riva M., Ronzoni M., Rosso M.G., Rottoli M., Rovaris M., Salemi G., Salvetti M., Santangelo M., Santangelo G., Santuccio G., Sarchielli P., Scarpini E., Sechi G.P., Severi S., Sinisi L., Sola P, Spitaleri D., Tassinari T., Tedeschi G., Tonietti S., Torri Clerici V., Totaro R., Traccis S., Turla M., Uccelli A., Ulivelli M., Valentino P., Valeriani M., Venturi S., Vianello M., Zaffaroni M., Trojano, Maria, Bergamaschi, Roberto, Amato, Maria Pia, Comi, Giancarlo, Ghezzi, Angelo, Lepore, Vito, Marrosu, Maria Giovanna, Mosconi, Paola, Patti, Francesco, Ponzio, Michela, Zaratin, Paola, Battaglia, Mario Alberto, Acquistapace, D, Aguglia, U, Amato, Mp, Annunziata, P, Ardito, B, Avolio, C, Balgera, R, Bandini, F, Banfi, P, Barone, P, Bellantonio, P, Bergamaschi, R, Bertolotto, A, Bertora, P, Bombardi, R, Bosco Zimatore, G, Bossio, Rb, Bramanti, P, Brescia Morra, V, Brioschi, Am, Bruzzone, M, Buccafusca, M, Busillo, V, Caneve, G, Caniatti, Lm, Capone, L, Capone, F, Cappellani, A, Cargnelutti, D, Cavaletti, G, Cavalla, P, Celani, Mg, Centonze, D, Chiveri, L, Clerici, R, Clerico, M, Cocco, E, Comi, G, Comi, C, Coniglio, Mg, Cordera, S, Corea, F, Cortese, A, Costantino, G, Cottone, S, Crociani, P, D'Andrea, F, Danni, Mc, De Luca, G, de Pascalis, D, De Robertis, F, De Stefano, N, Di Battista, G, Di Napoli, M, Falcini, M, Fausto, F, Ferrò, Mt, Florio, C, Fortunato, M, Frittelli, C, Galgani, S, Gallo, P, Gatto, M, Gazzola, P, Geda, C, Giordano, A, Granella, F, Grasso, Mg, Grimaldi, Lme, Imperiale, D, Lo Russo, L, Logullo, Fo, Lugaresi, A, Lus, G, Maccarrone, G, Maimone, D, Malagù, S, Marconi, R, Maritato, P, Massacesi, L, Mazzoni, M, Meucci, G, Mirabella, M, Montepietra, S, Nasuelli, D, Neri, W, Orefice, G, Parodi, S, Pasquali, L, Passarella, B, Patti, F, Peresson, M, Perla, F, Pesci, I, Piantadosi, C, Piras, Ml, Pizio, Nr, Pozzilli, C, Protti, A, Pugliatti, M, Quatrale, R, Ragno, M, Rezzonico, M, Ribizzi, G, Riva, M, Ronzoni, M, Rosso, Mg, Rottoli, M, Rovaris, M, Salemi, G, Salvetti, M, Santangelo, M, Santangelo, G, Santuccio, G, Sarchielli, P, Scarpini, E, Sechi, Gp, Severi, S, Sinisi, L, Sola, P, Spitaleri, D, Tassinari, T, Tedeschi, G, Tonietti, S, Torri Clerici, V, Totaro, R, Traccis, S, Trojano, M, Turla, M, Uccelli, A, Ulivelli, M, Valentino, P, Valeriani, M, Venturi, S, Vianello, M, Zaffaroni, M., Amato, M, Ghezzi, A, Lepore, V, Marrosu, M, Mosconi, P, Ponzio, M, Zaratin, P, Battaglia, M, Bossio, R, Brioschi, A, Caniatti, L, Celani, M, Coniglio, M, D’Andrea, F, Danni, M, Ferrò, M, Grasso, M, Grimaldi, L, Logullo, F, Piras, M, Pizio, N, Rosso, M, Sechi, G, and Zaffaroni, M

Subjects
Register (sociolinguistics), Adult, Male, Knowledge management, Databases, Factual, Epidemiology, media_common.quotation_subject, Disease epidemiology, Multiple sclerosis, Quality of care, Register, Longitudinal Studie, Dermatology, NO, Cohort Studies, Databases, 03 medical and health sciences, 0302 clinical medicine, Multiple Sclerosi, Humans, Quality (business), Longitudinal Studies, 030212 general & internal medicine, Registries, Epidemiology, Multiple sclerosis, Quality of care, Register, Adult, Cohort Studies, Data Collection, Databases, Factual, Female, Humans, Italy, Longitudinal Studies, Male, Multiple Sclerosis, Registries, Factual, media_common, Data collection, business.industry, Data Collection, Correction, Female, Italy, Multiple Sclerosis, General Medicine, Register data, Psychiatry and Mental Health, Observational study, Original Article, Settore MED/26 - Neurologia, Business, Neurology (clinical), Cohort Studie, 030217 neurology & neurosurgery, 2708, Human
Abstract

The past decade has seen extraordinary increase in worldwide availability of and access to several large multiple sclerosis (MS) databases and registries. MS registries represent powerful tools to provide meaningful information on the burden, natural history, and long-term safety and effectiveness of treatments. Moreover, patients, physicians, industry, and policy makers have an active interest in real-world observational studies based on register data, as they have the potential to answer the questions that are most relevant to daily treatment decision-making. In 2014, the Italian MS Foundation, in collaboration with the Italian MS clinical centers, promoted and funded the creation of the Italian MS Register, a project in continuity with the existing Italian MS Database Network set up from 2001. Main objective of the Italian MS Register is to create an organized multicenter structure to collect data of all MS patients for better defining the disease epidemiology, improving quality of care, and promoting research projects in high-priority areas. The aim of this article is to present the current framework and network of the Italian MS register, including the methodology used to improve the quality of data collection and to facilitate the exchange of data and the collaboration among national and international groups. The past decade has seen extraordinary increase in worldwide availability of and access to several large multiple sclerosis (MS) databases and registries. MS registries represent powerful tools to provide meaningful information on the burden, natural history, and long-term safety and effectiveness of treatments. Moreover, patients, physicians, industry, and policy makers have an active interest in real-world observational studies based on register data, as they have the potential to answer the questions that are most relevant to daily treatment decision-making. In 2014, the Italian MS Foundation, in collaboration with the Italian MS clinical centers, promoted and funded the creation of the Italian MS Register, a project in continuity with the existing Italian MS Database Network set up from 2001. Main objective of the Italian MS Register is to create an organized multicenter structure to collect data of all MS patients for better defining the disease epidemiology, improving quality of care, and promoting research projects in high-priority areas. The aim of this article is to present the current framework and network of the Italian MS register, including the methodology used to improve the quality of data collection and to facilitate the exchange of data and the collaboration among national and international groups.

Published
2019

2. Diagnostic and therapeutic workup of erectile dysfunction: results from a delphi consensus of andrology experts

Author

Isidori, A. M., Giammusso, B., Corona, G., Verze, P., Albanesi, L., Antomarchi, F., Arcaniolo, D., Balercia, G., Barbonetti, A., Barletta, D., Barrese, F., Bellastella, G., Biggio, A., Bitelli, M., Botturi, A., Brancato, T., Branchina, A., Cai, T., Canale, D., Capone, L., Capone, M., Carluccini, A., Citarrella, R., Cocci, A., Corvese, F., Cozza, P. P., Creta, M., D'Andrea, S., Dalena, G., Damiano, R., Defeudis, G., Del Grasso, A., Delbarba, A., Delle Rose, A., Di Crosta, G., Filippo, Di, Di Lena, S., Di Martino, M., Di Millo, F., Di Palma, P., Diazzi, D., Dicuio, M., Diosi, D., Fabbri, A., Fattorini, G., Florio, M., Formiconi, A., Franco, G., Galdiero, M., Giambersio, A. M., Gianfrilli, D., Giovannone, R., Granata, A. M., Iafrate, M., Iapicca, G., Iatrino, G., Ilacqua, N., Innocenti, F., Italiano, E., Izzo, A., Izzo, P., Lamartina, M., Ledda, A. F., Lepri, L., C. F., Lo, Lombardo, F., Luca, G., Macchione, L., Maga, T., Matteo, M., Malvestiti, G. M., Marella, G., Maretti, C., Maturo, G., Mazzaferro, D., Mazzilli, R., Migliorini, F., Milardi, D., Minardi, V., Moiso, A., Mondaini, N., Moretti, M., Motta, G., Nerva, F., Pastore, A. L., Paulis, G., Piazza, N., Pili, M., Pistone, A., Pivonello, R., Pizzocaro, A., Polverini, M., Provinzano, V., Rastrelli, G., Risi, O., Rocchegiani, A., Rolle, L., Romanelli, F., Romano, G., Russo, G. I., Salemi, G., Salzano, C., Sanna, F., Sansone, A., Santi, D., Scalese, G. A., Scarano, P., Scroppo, F. I., Serrao, M. F., Sidoti, G., Silvestre, G., Simone, O., Sorrentino, M., Tallis, V., Tammaro, R., Ughi, G., Vagnoni, V., Vavallo, A., Vecchio, D., Vita, A., Zicarelli, P., and Zucchi, A.

Subjects
Consensus, erectile dysfunction, Urology, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, education, 030232 urology & nephrology, lcsh:Medicine, Dermatology, Delphi, Consensus method, Likert scale, Andrology, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Endocrinology, Erectile Dysfunction, PDE5 Inhibitors, Treatment, Voting, medicine, PDE5 inhibitors, computer.programming_language, media_common, 030219 obstetrics & reproductive medicine, treatment, business.industry, lcsh:R, lcsh:Other systems of medicine, medicine.disease, lcsh:RZ201-999, consensus, delphi, Phosphodiesterase Type 5 Inhibitors, Clinical Practice, Psychiatry and Mental health, Erectile dysfunction, Hot topics, Reproductive Medicine, business, computer
Abstract

Introduction Erectile dysfunction is a highly prevalent condition. Existing guidelines provide recommendations for diagnosis and treatment, but they are often disregarded in clinical practice in favor of a “patient-tailored” approach. Objectives We planned a Delphi consensus method to bridge the gap between evidence-based medicine and the real-life approach in daily practice. Materials and Methods The Advisory Board prepared 15 statements on debated topics in andrology, each including 4–6 items designed as a 5-point Likert scale. After a validation phase, the questionnaire was sent by e-mail to a panel of experts for a first round of voting; members of the panel were later invited to a second round of voting, preceded by discussion of the “hot topics” identified in the first round. Results The first round of the Delphi consensus involved 101 experts; 71 (70%) also took part in the second round of voting. The Advisory Board deemed 22 items to be worthy of debate, and these underwent the second round of voting. “Real-life” results from the survey proved quite different from evidence-based recommendations. Conclusion Although guidelines suggest the best approach for a “standard” patient, real-life settings require flexibility. Diagnostic and therapeutic approaches should be tailored to the patients’ needs. Phosphodiesterase type 5 inhibitors are recognized as the first-line therapy in both settings, including the newly introduced sildenafil orodispersible film. Indications from the panel might help close the gap between recommendations from guidelines and real-life practice in relation to the diagnosis and treatment of erectile dysfunction.

Published
2019

3. Patient-reported outcomes measure for children born preterm: validation of the SOLE VLBWI Questionnaire, a new quality of life self-assessment tool

Author

Olivieri, I., M Bova, S., Fazzi, E., Ricci, Daniela, Tinelli, F., Montomoli, C., Rezzani, C., Balottin, U., Orcesi, S., Ariaudo, G., Capone, L., Spairani, S., Stronati, M., Figar, T., Mastrangelo, Marica, Krachmalnicoff, A., Lista, G., Accorsi, P., Martelli, P., Rossi, A., Micheletti, S., Zaccagnino, M., Chirico, G., Mallardi, M., Quintiliani, Michela, Romeo, Domenico Marco, Gallini, Francesca, Battini, Roberta, and Comparini, A.

Subjects
Self-assessment, Male, Self-Assessment, Psychometrics, Neurology (clinical), Pediatrics, Perinatology and Child Health, Developmental Neuroscience, Pediatrics, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Cronbach's alpha, 030225 pediatrics, Surveys and Questionnaires, Humans, Infant, Very Low Birth Weight, Medical history, Patient Reported Outcome Measures, Child, Measure (data warehouse), Alpha Value, Very Low Birth Weight, Infant, Reproducibility of Results, Perinatology and Child Health, Focus group, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Quality of Life, Female, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract

Aim This study was conducted to develop and validate a new self-report questionnaire for measuring quality of life (QoL), at school age, in children with a very low birthweight (VLBW). Method Through a focus group approach, children were involved directly in defining the questionnaire items, which were presented as illustrations rather than written questions. This preliminary validation of the questionnaire was conducted in 152 participants with VLBW (aged 7–11y) randomly selected from the five participating Italian centres. The questionnaire was completed by children and parents separately; data on children's demographic and medical history, and intellectual, adaptive, and behavioural functioning were collected using standardized scales. All the children also completed the Paediatric Quality of Life Inventory (PedsQL), another Italian-language measure of QoL in children. Results Our questionnaire was readily accepted and understood, and quick to complete. The Cronbach's alpha value showed it to be a reliable instrument. The child-compiled version correlated well with the PedsQL, whereas no correlations emerged with the other scales used, IQ, or degree of impairment. Conversely, these variables correlated significantly with the parent-compiled version. Children's and parents’ answers were divergent on practically all the items. Interpretation The results confirm the validity of the new instrument and highlight a poor overlap between parents’ and children's perspectives.

Published
2016

4. Optical Coherence Tomography Biomarkers of Inflammation in Diabetic Macular Edema Treated by Fluocinolone Acetonide Intravitreal Drug-Delivery System Implant

Author

Luigi Capone, Francesco Bandello, Rosangela Lattanzio, Emanuela Aragona, Piero Zollet, Alessandro Arrigo, Arrigo, A., Capone, L., Lattanzio, R., Aragona, E., Zollet, P., and Bandello, F.

Subjects
medicine.medical_specialty, Visual acuity, Fluocinolone acetonide implant, genetic structures, Diabetic macular edema, Inflammation, Hyperreflective foci, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Vascularity, Fluocinolone acetonide, Optical coherence tomography, Ophthalmology, medicine, Choroidal biomarkers, 0101 mathematics, Original Research, medicine.diagnostic_test, business.industry, 010102 general mathematics, Choroidal vascularity index, RE1-994, eye diseases, Drug delivery, 030221 ophthalmology & optometry, Implant, sense organs, medicine.symptom, business, medicine.drug
Abstract

Introduction: The fluocinolone acetonide (FAc) intravitreal drug-delivery system implant is a recent, second-line, intravitreal drug for the management of diabetic macular edema (DME). FAc acts against DME with a major anti-inflammatory effect. Despite the already proved efficacy, a number of patients still show persistent DME and require anti-VEGF retreatment. The main aim of the present study was to assess the relationship between quantitative biomarkers of inflammation and both DME recovery and the need for additional anti-VEGF in eyes treated by FAc implant. Methods: The study was designed as prospective and interventional with 1 year of follow-up. We analyzed structural optical coherence tomography (OCT) quantitative biomarkers of inflammation, namely choroidal hyperreflective foci (HF) and the choroidal vascularity index (CVI), and we assessed the relationship with other clinically relevant biomarkers and the outcome achieved after 1year. Moreover, we stratified DME eyes in good and poor responders to FAc implant to highlight clinically relevant differences. Results: Our study included 50 eyes (50 patients) treated by FAc implant. We found significant best-corrected visual acuity (BCVA) and central macular thickness (CMT) improvements after 1year. Good responders started with worse visual acuity and higher CMT than poor responders, but gained letters significantly at the end of the follow-up, whereas poor responders showed stable BCVA values. Good responders were characterized by significantly higher choroidal HF and lower CVI than poor responders. Poor responders required significantly higher additional anti-VEGF treatments. Conclusions: Quantitative structural OCT biomarkers of inflammation allowed distinguishing different inflammatory profiles of DME. The inflammatory component helped to categorize DME eyes in good and poor responders to FAc implant.

Published
2020

5. Ocular Features and Associated Systemic Findings in SARS-CoV-2 Infection

Author

Michele Cavalleri, Marco Battista, Luigi Capone, Alessio Grazioli Moretti, Vincenzo Starace, Francesca Gorgoni, Eleonora Corbelli, Francesco Bandello, Maria Brambati, Francesco Nadin, Domenico Grosso, Carlo Di Biase, Matteo Pederzolli, Cavalleri, M., Brambati, M., Starace, V., Capone, L., Nadin, F., Pederzolli, M., Gorgoni, F., Di Biase, C., Corbelli, E., Battista, M., Grazioli Moretti, A., Grosso, D., and Bandello, F.

Subjects
Male, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, RT-PCR, Betacoronavirus, Conjunctivitis, Viral, 03 medical and health sciences, 0302 clinical medicine, Pandemic, conjunctivitis, Humans, Immunology and Allergy, Medicine, Pandemics, 030203 arthritis & rheumatology, SARS-CoV-2, business.industry, COVID-19, Middle Aged, Virology, Respiratory support, Ophthalmology, Cross-Sectional Studies, 030221 ophthalmology & optometry, RNA, Viral, Female, Coronavirus Infections, business, Conjunctiva
Abstract

Purposes: To describe the prevalence of ocular features among COVID-19 patients and their relationship with clinical data, inflammatory markers and respiratory support therapy (including CPAP); to investigate SARS-CoV-2 in ocular secretions of symptomatic patients. Methods: 172 COVID-19 patients were evaluated for presence of ocular manifestations. Clinical and laboratory data were also reviewed. Conjunctival swabs were analyzed for SARS-CoV-2 by RT-PCR. Results: Forty-five patients (26.2%) reported ocular manifestations. Patients treated with CPAP were more likely to have ocular abnormalities (p

Published
2020

6. Persistent or Recurrent Diabetic Macular Edema After Fluocinolone Acetonide 0.19 mg Implant: Risk Factors and Management

Author

Alessandro Rabiolo, Piero Zollet, Maria Vittoria Cicinelli, Luigi Capone, Rosangela Lattanzio, Francesco Bandello, Cicinelli, M. V., Rabiolo, A., Zollet, P., Capone, L., Lattanzio, R., and Bandello, F.

Subjects
Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Visual acuity, genetic structures, Diabetic macular edema, Visual Acuity, Angiogenesis Inhibitors, Macular Edema, 03 medical and health sciences, 0302 clinical medicine, Fluocinolone acetonide, Pro re nata, Recurrence, Risk Factors, Ophthalmology, medicine, Humans, Medical history, Prospective Studies, Prospective cohort study, Glucocorticoids, 030304 developmental biology, Aged, Aged, 80 and over, Drug Implants, 0303 health sciences, Diabetic Retinopathy, business.industry, Middle Aged, eye diseases, Fluocinolone Acetonide, Baseline characteristics, 030221 ophthalmology & optometry, Female, Implant, medicine.symptom, business, medicine.drug
Abstract

Purpose: To investigate baseline characteristics of patients undergoing additional antivascular endothelial growth factor (VEGF) injections for residual or recurrent diabetic macular edema (DME) in the first year after 0.19-mg fluocinolone acetonide (FAc) implant. Design: Prospective cohort study. Methods: Ninety-four eyes of 66 patients received an FAc implant. Eyes with persistent or recurrent DME were managed with pro re nata anti-VEGF agents. Demographic data and medical history were collected at baseline. Best-corrected visual acuity and central macular thickness were measured every 2 months. The 3 outcomes explored were 1) the risk factors for administration of additional anti-VEGF agents, 2) the interval from FAc to first anti-VEGF injection; and 3) the number of anti-VEGF doses required to maintain regression of DME. Results: Eighteen eyes (19.1%) of 13 patients received 1.3 ± 0.6 anti-VEGF injections. These eyes had significantly thicker central macular thickness at baseline and over the entire follow-up period (P < .001); best-corrected visual acuity was similar at every time point to eyes that were not receiving extra DME treatments. Eyes without preexistent panretinal photocoagulation (PRP) had a higher risk to undergo supplemental treatments (hazard ratio 1.5 [95% confidence interval 1.1-2.5, P = .03). The interval between FAc implant and the first anti-VEGF had a significant linear positive relationship with the number of dexamethasone implants before FAc implant (P = .002, R2 = 0.47). No association was found between baseline factors and the number of injections given. Conclusion: Anti-VEGF agents are efficient treatment to maintain visual acuity in residual/recurrent DME after FAc. Patients with higher baseline central macular thickness and with no previous central macular thickness are more likely to require additional treatments to control DME.

Published
2020

7. HYPERREFLECTIVE FOVEAL SPOTS IN PATIENTS WITH VITREORETINAL ANOMALIES: A Qualitative and Quantitative Analysis

Author

Lorenzo Iuliano, Alessandro Marchese, Luigi Capone, Alessandro Arrigo, Luisa Pierro, Francesco Bandello, Emanuela Aragona, Pierro, L., Arrigo, A., Capone, L., Aragona, E., Marchese, A., Iuliano, L., and Bandello, F.

Subjects
Male, 0301 basic medicine, Fovea Centralis, medicine.medical_specialty, Visual acuity, genetic structures, Fundus Oculi, Visual Acuity, optical coherence tomography angiography, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Retinal Diseases, Optical coherence tomography, Foveal, Ophthalmology, Humans, Medicine, In patient, Prospective Studies, Fluorescein Angiography, Prospective cohort study, optical coherence tomography, medicine.diagnostic_test, business.industry, Retinal, General Medicine, Middle Aged, medicine.disease, Control subjects, eye diseases, Capillaries, hyperreflective foveal spots, Cross-Sectional Studies, 030104 developmental biology, chemistry, 030221 ophthalmology & optometry, Female, vitreomacular interface abnormalities, sense organs, medicine.symptom, Epiretinal membrane, business, Tomography, Optical Coherence
Abstract

PURPOSE: To describe structural optical coherence tomography (OCT) and OCT angiography features in patients who have developed hyperreflective foveal spots with or without vitreomacular interface abnormalities or with vitreous adhesion alone. METHODS: The study design was observational and cross sectional. The presence of defined epiretinal membrane was considered an exclusion criterion. All patients underwent complete ophthalmologic examination, with structural OCT and OCT angiography acquisitions. Both qualitative and quantitative analyses of OCT angiography reconstructions were performed for superficial capillary plexus, deep capillary plexus, and choriocapillaris. RESULTS: Thirty patients (20 men; mean age, 55.2 years) showing hyperreflective foveal spots on structural OCT and 30 healthy control subjects (20 men; mean age, 54.7 years) were enrolled. Best-corrected visual acuity was 0.0 ± 0.0 logarithm of the minimum angle of resolution (20/20 Snellen) for both patients and control subjects. Following global and parafoveal/extrafoveal analyses, both superficial capillary plexus and deep capillary plexus showed significant reduction (P < 0.001). Significant superficial capillary plexus and deep capillary plexus changes were also detected in contralateral eyes (P < 0.001). CONCLUSION: Hyperreflective foveal spots might be seen as the initial effect of traction forces causing Müller cell and external retinal layer disruption, leading to the onset of vitreomacular disease. These changes also have an effect on the retinal vascular network. Further larger prospective studies are necessary to confirm our findings.

Published
2020

8. Quantitative changes in the ageing choriocapillaris as measured by swept source optical coherence tomography angiography

Author

Riccardo Sacconi, Enrico Borrelli, Francesco Gelormini, Alessandro Rabiolo, Lea Querques, Giuseppe Querques, Adriano Carnevali, Marco Casaluci, Luigi Capone, Francesco Bandello, Eleonora Corbelli, Sacconi, R., Borrelli, E., Corbelli, E., Capone, L., Rabiolo, A., Carnevali, A., Casaluci, M., Gelormini, F., Querques, L., Bandello, F., and Querques, G.

Subjects
Adult, Male, medicine.medical_specialty, Aging, Fovea Centralis, choriocapillari, healthy subject, optical coherence tomography angiography, vessel diameter index, perfusion density, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Foveal, vessel density, Ophthalmology, medicine, Humans, Fluorescein Angiography, vessel length density, Aged, Aged, 80 and over, aging, choriocapillaris, healthy subjects, business.industry, Choroid, Length density, Healthy subjects, Outcome measures, Retinal Vessels, Optical coherence tomography angiography, Middle Aged, Sensory Systems, Vessel diameter, Cross-Sectional Studies, Ageing, 030221 ophthalmology & optometry, Female, business, Perfusion, 030217 neurology & neurosurgery, Tomography, Optical Coherence
Abstract

AimTo analyse quantitative optical coherence tomography angiography (OCTA) parameters of choriocapillaris (CC) at the foveal, perifoveal and parafoveal regions in healthy subjects of different age.MethodsIn this observational cross-sectional study, consecutive healthy subjects underwent swept source OCTA (PLEX Elite 9000, Carl Zeiss Meditec, USA). 3×3 mm and 6×6 mm scans centred on the fovea were acquired analysed and postprocessed with thresholding and binarisation processes. The main outcome measures included CC quantitative OCTA features (perfusion density (PD), vessel length density (VLD) and vessel diameter index (VDI)) at the foveal, perifoveal and parafoveal regions, and their relationship with age.ResultsSeventy-two eyes (72 patients, mean age 47.4±19.2 years, mean axial length 24.0±0.7 mm) were included. The mean PD was statistically lower in the foveal region compared with the parafoveal region in 3×3 mm scans (p=0.009). In subjects aged 70–80, PD of the foveal region was significantly reduced compared with the perifoveal region in 6×6 mm scans (p=0.008). A strong negative correlation was found between PD and ageing in the foveal, parafoveal and perifoveal regions (pConclusionsWe reported in vivo a strong negative correlation between PD and ageing in the CC of healthy subjects. This reduction seems related to a reduced diameter, and not to a reduced number, of capillaries. The age-related changes were higher in the central area compared with the perifoveal area.

Published
2018

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