1. MECHANISMS OF HYPNOTIC ANALGESIA EXPLAINED BY FUNCTIONAL MAGNETIC RESONANCE (fMRI)
- Author
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Francesco Finatti, Annalena Venneri, Federica Gasparotti, Antonio M. Lapenta, Maria Rosaria Stabile, Federica Albertini, Valérie Tikhonoff, Micaela Mitolo, Enrico Facco, Edoardo Casiglia, Casiglia E., Finatti F., Tikhonoff V., Stabile M.R., Mitolo M., Albertini F., Gasparotti F., Facco E., Lapenta A.M., and Venneri A.
- Subjects
Adult ,Male ,Complementary and Manual Therapy ,Hypnosis ,genetic structures ,medicine.drug_class ,Pain ,behavioral disciplines and activities ,050105 experimental psychology ,Hypnotic ,03 medical and health sciences ,0302 clinical medicine ,Hypnosis, Anesthetic ,medicine ,Humans ,Pain Management ,0501 psychology and cognitive sciences ,MODULATION ,CEREBELLUM ,PAIN PERCEPTION ,HYPNOSIS ,GATE ,DIFFER ,medicine.diagnostic_test ,Functional Neuroimaging ,05 social sciences ,Brain ,Magnetic resonance imaging ,Magnetic Resonance Imaging ,Clinical Psychology ,Female ,Functional magnetic resonance imaging ,Psychology ,Neuroscience ,030217 neurology & neurosurgery ,Human - Abstract
Hypnotic-focused analgesia (HFA) was produced in 20 highly hypnotizable subjects receiving nociceptive stimulations while undergoing functional magnetic resonance imaging (fMRI). The fMRI pattern in brain cortex activation while receiving a painful stimulus was recorded both during nonhypnosis and during HFA. The scanning protocol included the acquisition of a T1-weighted structural scan, 4 functional scans, a T2-weighted axial scan, and a fluid attenuated inversion recovery (FLAIR) scan. Total imaging time, including localization and structural image acquisitions, was approximately 60minutes. Without HFA, the subjects reported subjective presence of pain, and the cortex primary sensory areas S1, S2, and S3 were activated. During HFA, the subjects reported complete absence of subjective pain and S1, S2, and S3 were deactivated. The findings suggest that HFA may prevent painful stimuli from reaching the sensory brain cortex, possibly through a gate-control mechanism.
- Published
- 2020
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