1. Quality of life in women diagnosed with breast cancer after a 12-month treatment of lifestyle modifications
- Author
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Giovanna Antonelli, Agostino Steffan, Livia S. A. Augustin, Samuele Massarut, Diego Serraino, Monica Pinto, Francesco Ferraù, Concetta Montagnese, Amalia Farina, Anna Crispo, Francesco Messina, Pasqualina C. Fiorillo, Ilaria Calabrese, Laura Caggiari, Anita Minopoli, Gennaro Guerra, Flavia Nocerino, Maria Grazia Grimaldi, Elvira Palumbo, Massimiliano D’Aiuto, Daniela Cianniello, Rosa Pica, Chiara Evangelista, Massimo Rinaldo, Giuseppa Scandurra, Michelino De Laurentiis, Nadia Esindi, Marco Cuomo, Gabriele Riccardi, Melania Prete, Gerardo Botti, Massimo Libra, Serena Cubisino, Guglielmo Thomas, Davide Gatti, Giuseppe Luigi Banna, Valentina Martinuzzo, David J.A. Jenkins, Sergio Coluccia, Giuseppe Porciello, Ernesta Cavalcanti, Francesca Catalano, Rosalba Rossello, Luca Falzone, S. Vitale, Bruna Grilli, Luigina Poletto, Egidio Celentano, Carmen Pacilio, Montagnese, C., Porciello, G., Vitale, S., Palumbo, E., Crispo, A., Grimaldi, M., Calabrese, I., Pica, R., Prete, M., Falzone, L., Libra, M., Cubisino, S., Poletto, L., Martinuzzo, V., Coluccia, S., Esindi, N., Nocerino, F., Minopoli, A., Grilli, B., Fiorillo, P. C., Cuomo, M., Cavalcanti, E., Thomas, G., Cianniello, D., Pinto, M., De Laurentiis, M., Pacilio, C., Rinaldo, M., D'Aiuto, M., Serraino, D., Massarut, S., Caggiari, L., Evangelista, C., Steffan, A., Catalano, F., Banna, G. L., Scandurra, G., Ferrau, F., Rossello, R., Antonelli, G., Guerra, G., Farina, A., Messina, F., Riccardi, G., Gatti, D., Jenkins, D. J. A., Celentano, E., Botti, G., and Augustin, L. S. A.
- Subjects
Adult ,Quality of life ,medicine.medical_specialty ,Constipation ,Mediterranean diet ,Nausea ,Health Status ,Breast Neoplasms ,lcsh:TX341-641 ,Survivorship ,Diet, Mediterranean ,Diet Surveys ,Article ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Cancer Survivors ,Internal medicine ,Surveys and Questionnaires ,medicine ,Vitamin D and neurology ,Humans ,030212 general & internal medicine ,Healthy Lifestyle ,Vitamin D ,Nutrition and Dietetics ,business.industry ,Physical activity ,social sciences ,Middle Aged ,medicine.disease ,Lifestyle ,humanities ,Exercise Therapy ,Treatment Outcome ,030220 oncology & carcinogenesis ,Dietary Supplements ,Vomiting ,Patient Compliance ,Female ,Analysis of variance ,medicine.symptom ,business ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression analyses were performed to assess treatment effects on HRQoL. Increases were observed in global health status (p <, 0.001), physical (p = 0.003), role (p = 0.002) and social functioning (p <, 0.001), body image (p <, 0.001), future perspective (p <, 0.001), well-being (p = 0.001), and reductions in fatigue (p <, 0.001), nausea and vomiting (p = 0.015), dyspnea (p = 0.001), constipation (p = 0.049), financial problems (p = 0.012), sexual functioning (p = 0.025), systematic therapy side effects (p <, 0.001) and breast symptoms (p = 0.004). Multiple regression analyses found inverse associations between changes in BMI and global health status (p = 0.048) and between serum 25(OH)D levels and breast symptoms (p = 0.002). A healthy lifestyle treatment of traditional Mediterranean diet and exercise may impact positively on HRQoL in BC survivors possibly through reductions in body weight while vitamin D sufficiency may improve BC-related symptoms. These findings are relevant to BC survivors whose lower HRQoL negatively affects treatment compliance and disease outcomes.
- Published
- 2021