1. Neck flexor weakness at diagnosis predicts respiratory impairment in amyotrophic lateral sclerosis
- Author
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Umberto Manera, Cristina Moglia, Andrea Calvo, Alberta Circiello, Filippo De Mattei, Fabrizio D'Ovidio, Maria Claudia Torrieri, Antonio Canosa, Adriano Chiò, and Rosario Vasta
- Subjects
Male ,amyotrophic lateral sclerosis ,cohort studies ,epidemiology ,survival analysis ,medicine.medical_specialty ,Delayed Diagnosis ,Neck muscle weakness ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Amyotrophic lateral sclerosis ,Survival analysis ,Aged ,Retrospective Studies ,Muscle Weakness ,business.industry ,Amyotrophic Lateral Sclerosis ,Hazard ratio ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Dysphagia ,Confidence interval ,Neurology ,Female ,Neurology (clinical) ,medicine.symptom ,Respiratory Insufficiency ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
BACKGROUND AND PURPOSE The purpose was to assess the prognostic role of neck muscle weakness at diagnosis in amyotrophic lateral sclerosis (ALS) patients with respect to survival and respiratory impairment. METHODS A retrospective cohort study was conducted. All ALS patients seen in the Turin ALS Centre from 2007 to 2014 were included. Muscle strength at diagnosis was evaluated using the Medical Research Council (MRC) scale. Survival was considered as the time from diagnosis to death or tracheostomy; time to respiratory impairment was considered as the interval from diagnosis to the first event amongst an ALS Functional Rating Scale revised item 10
- Published
- 2020