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Start Over Author "Laurent Auboire" Topic 0302 clinical medicine
6 results on '"Laurent Auboire"'

1. Acoustic and Elastic Properties of a Blood Clot during Microbubble-Enhanced Sonothrombolysis: Hardening of the Clot with Inertial Cavitation

Author

Ayache Bouakaz, Jean-Michel Escoffre, Damien Fouan, Laurent Auboire, Jean-Marc Gregoire, Frédéric Ossant, Camille Plag, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT), Escoffre, Jean-Michel, Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
elastography, Materials science, medicine.medical_treatment, Pharmaceutical Science, 01 natural sciences, Article, microbubbles, 03 medical and health sciences, Pharmacy and materia medica, 0302 clinical medicine, Thrombolytic drug, 0103 physical sciences, medicine, 010301 acoustics, [SDV.IB] Life Sciences [q-bio]/Bioengineering, medicine.diagnostic_test, business.industry, ultrasound, Ultrasound, Wave speed, ultrafast imaging, stroke, 3. Good health, RS1-441, Cavitation, Microbubbles, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Elastography, rtPA, business, 030217 neurology & neurosurgery, Hardening (computing), High frequency ultrasound, Biomedical engineering
Abstract

Stroke is the second leading cause of death worldwide. Existing therapies present limitations, and other therapeutic alternatives are sought, such as sonothrombolysis with microbubbles (STL). The aim of this study was to evaluate the change induced by STL with or without recombinant tissue-type plasminogen activator (rtPA) on the acoustic and elastic properties of the blood clot by measuring its sound speed (SoS) and shear wave speed (SWS) with high frequency ultrasound and ultrafast imaging, respectively. An in-vitro setup was used and human blood clots were submitted to a combination of microbubbles and rtPA. The results demonstrate that STL induces a raise of SoS in the blood clot, specifically when combined with rtPA (p &lt, 0.05). Moreover, the combination of rtPA and STL induces a hardening of the clot in comparison to rtPA alone (p &lt, 0.05). This is the first assessment of acoustoelastic properties of blood clots during STL. The combination of rtPA and STL induce SoS and hardening of the clot, which is known to impair the penetration of thrombolytic drugs and their efficacy.

Published
2021

2. Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring

Author

Laurent Auboire, Jean-Michel Escoffre, Damien Fouan, Emma Kanbar, Charles A. Sennoga, Ayache Bouakaz, Paul-Armand Dujardin, Escoffre, Jean-Michel, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT), Centre d’Investigation Clinique [Tours] CIC 1415 (CIC ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 5 : imagerie et ultrasons, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Drug, medicine.medical_specialty, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, media_common.quotation_subject, Combined use, Contrast Media, Pharmaceutical Science, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, medicine, Medical imaging, Animals, Humans, Medical physics, ComputingMilieux_MISCELLANEOUS, Ultrasonography, media_common, [SDV.IB] Life Sciences [q-bio]/Bioengineering, Microbubbles, business.industry, Ultrasound, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, 3. Good health, Therapeutic monitoring, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Drug delivery, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Drug Monitoring, business, Sonoporation, Biomedical engineering
Abstract

Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues by employing different mechanisms of drug release is becoming feasible. Areas covered: We sought to describe: the nature and features of UCAs; outline current contrast-specific imaging modes; before describing a variety of strategies for using ultrasound and microbubbles as a drug delivery system. Our expert opinion focusses on results and prospects of using ultrasound and microbubbles as a dual modality for drug delivery and therapeutic monitoring. Expert opinion: Today, ultrasound and microbubbles present a realistic prospect as drug delivery tools that have been demonstrated in a variety of animal models and clinical indications. Besides delivering drugs, ultrasound and microbubbles have demonstrated added value through therapeutic monitoring and assessment. Successful evaluation of the sonoporation mechanism(s), ultrasound parameters, drug type and dose will need to be addressed before translating this technology for clinic use. Ultimately, the development of a strategy for monitoring targeted delivery and its implementation in clinical practice would advance therapeutic treatment to a new qualitative level.

Published
2016

3. Comment on 'The Enhancing Effect of Focused Ultrasound on TNK-Tissue Plasminogen Activator-Induced Thrombolysis using an In Vitro Circulating Flow Model'

Author

Laurent Auboire, Jean-Michel Escoffre, Escoffre, Jean-Michel, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
medicine.medical_treatment, 02 engineering and technology, Focused ultrasound, 03 medical and health sciences, 020210 optoelectronics & photonics, 0302 clinical medicine, Fibrinolytic Agents, 0202 electrical engineering, electronic engineering, information engineering, Medicine, TNK-tissue plasminogen activator, Thrombolytic Therapy, Data flow model, ComputingMilieux_MISCELLANEOUS, [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Fibrinolysis, Rehabilitation, Thrombolysis, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, In vitro, 3. Good health, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Tissue Plasminogen Activator, Cancer research, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Surgery, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

International audience

Published
2019

4. Quantitative Ultrasound in Ex Vivo Fibrotic Rabbit Livers

Author

Vanda Mendes, Anthony Novell, Emilie Franceschini, Yanis Mehdi Benane, Jean-Michel Escoffre, Olivier Basset, Laurent Auboire, Ayache Bouakaz, Ondes et Imagerie (O&I), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Ultrasonore, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Franceschini, Emilie, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
Liver Cirrhosis, Male, Pathology, medicine.medical_specialty, Acoustics and Ultrasonics, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Biophysics, Chronic liver disease, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Liver stiffness, Fibrosis, 0103 physical sciences, medicine, Animals, Radiology, Nuclear Medicine and imaging, 010301 acoustics, Grading (tumors), [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Shear wave elastography, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], Radiological and Ultrasound Technology, business.industry, medicine.disease, 3. Good health, Patient management, Quantitative ultrasound, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Liver, Elasticity Imaging Techniques, 030211 gastroenterology & hepatology, Rabbits, business, Ex vivo
Abstract

Liver fibrosis is the common result of chronic liver disease. Diagnosis and grading liver fibrosis for patient management is mainly based on blood tests and hepatic puncture-biopsy, which is particularly invasive. Quantitative ultrasound (QUS) techniques provide insight into tissue microstructure and are based on the frequency-based analysis of the signals from biologic tissues. This study aims to quantify how spectral-based QUS parameters change with fibrosis grade. The changes in QUS parameters of healthy and fibrotic rabbit liver samples were investigated and were compared with the changes in liver stiffness, using shear wave elastography. Overall, the acoustic concentration was found to decrease with increasing fibrosis grade, and the effective scatterer size was found to be higher in fibrotic livers when compared with normal liver. The result of this study indicates that the combination of three QUS parameters (stiffness, effective scatterer size and acoustic concentration) provides the best classification performance, especially for classifying healthy and fibrotic livers.

Published
2019

5. Microbubbles combined with ultrasound therapy in ischemic stroke: A systematic review of in-vivo preclinical studies

Author

Jean-Marc Hyvelin, Ayache Bouakaz, Jean-Michel Escoffre, François Tranquart, Laurent Auboire, Charles A. Sennoga, Frédéric Ossant, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Advice-US Consulting, Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Escoffre, Jean-Michel, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT)

Subjects
Physiology, Swine, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Ultrasonic Therapy, lcsh:Medicine, Pathology and Laboratory Medicine, Vascular Medicine, 030218 nuclear medicine & medical imaging, Brain Ischemia, 0302 clinical medicine, Medicine and Health Sciences, Medicine, Thrombolytic Therapy, Right Hemisphere, lcsh:Science, Stroke, Mammals, Multidisciplinary, Microbubbles, Ultrasound, Eukaryota, Brain, Animal Models, Arteries, Research Assessment, 3. Good health, Body Fluids, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Systematic review, Blood, Treatment Outcome, Experimental Organism Systems, Neurology, Vertebrates, Leporids, Rabbits, Anatomy, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Research Article, medicine.medical_specialty, Systematic Reviews, Cerebrovascular Diseases, MEDLINE, Hemorrhage, Research and Analysis Methods, 03 medical and health sciences, Signs and Symptoms, In vivo, Diagnostic Medicine, Animals, Medical physics, Left Hemisphere, Ischemic Stroke, business.industry, lcsh:R, Organisms, Biology and Life Sciences, Publication bias, Cerebral Arteries, medicine.disease, Rats, Disease Models, Animal, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Ischemic stroke, Amniotes, Cardiovascular Anatomy, Blood Vessels, lcsh:Q, business, Cerebral Hemispheres, 030217 neurology & neurosurgery
Abstract

Background Microbubbles (MBs) combined with ultrasound sonothrombolysis (STL) appears to be an alternative therapeutic strategy for acute ischemic stroke (IS), but clinical results remain controversial. Objective The aim of this systematic review is to identify the parameters tested; to assess evidence on the safety and efficacy on preclinical data on STL; and to assess the validity and publication bias. Methods Pubmed® and Web of ScienceTM databases were systematically searched from January 1995 to April 2017 in French and English. We included studies evaluating STL on animal stroke model. This systematic review was conducted in accordance with the PRISMA guidelines. Data were extracted following a pre-defined schedule by two of the authors. The CAMARADES criteria were used for quality assessment. A narrative synthesis was conducted. Results Sixteen studies met the inclusion criteria. The result showed that ultrasound parameters and types of MBs were heterogeneous among studies. Numerous positive outcomes on efficacy were found, but only four studies demonstrated superiority of STL versus recombinant tissue-type plasminogen activator on clinical criteria. Data available on safety are limited. Limitations Quality assessment of the studies reviewed revealed a number of biases. Conclusion Further in vivo studies are needed to demonstrate a better efficacy and safety of STL compared to currently approved therapeutic options. Systematic review registration http://syrf.org.uk/protocols/.

Published
2018

6. Tako-tsubo syndrome induced by a polidecanol injection: A case report

Author

Valentina Boccadamo, Joachim Alexandre, Cécile Labbé, and Laurent Auboire

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Magnetic resonance imaging, 030204 cardiovascular system & hematology, Chest pain, 03 medical and health sciences, 0302 clinical medicine, medicine, Sclerotherapy, 030212 general & internal medicine, Radiology, Tako tsubo, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Published
2016

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