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Your search keyword '"Lisa France"' showing total 2 results
Start Over Author "Lisa France" Topic 0302 clinical medicine
2 results on '"Lisa France"'

1. Lung Clearance Index to Track Acute Respiratory Events in School-Age Children with Cystic Fibrosis

Author

Lucy Perrem, Sanja Stanojevic, Michelle Shaw, Renee Jensen, Nancy McDonald, Sarah M. Isaac, Miriam Davis, Charles Clem, Julia Guido, Sylvia Jara, Lisa France, Melinda Solomon, Hartmut Grasemann, Valerie Waters, Neil Sweezey, Don B. Sanders, Stephanie D. Davis, and Felix Ratjen

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, School age child, business.industry, Lung Clearance Index, Critical Care and Intensive Care Medicine, medicine.disease, Cystic fibrosis, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Internal medicine, medicine, 030212 general & internal medicine, Respiratory system, business, MULTIPLE BREATH WASHOUT, Pulmonary exacerbation
Abstract

Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in preschool children with cystic fibrosis (CF), but its utility to identify and manage these events in school-ag...

Published
2021

2. Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation

Author

Wanda Phipatanakul, David T. Mauger, Theresa W. Guilbert, Leonard B. Bacharier, Sandy Durrani, Daniel J. Jackson, Fernando D. Martinez, Anne M. Fitzpatrick, Amparito Cunningham, Susan Kunselman, Lisa M. Wheatley, Cindy Bauer, Carla M. Davis, Bob Geng, Kirsten M. Kloepfer, Craig Lapin, Andrew H. Liu, Jacqueline A. Pongracic, Stephen J. Teach, James Chmiel, Jonathan M. Gaffin, Matthew Greenhawt, Meera R. Gupta, Peggy S. Lai, Robert F. Lemanske, Wayne J. Morgan, William J. Sheehan, Jeffrey Stokes, Peter S. Thorne, Hans C. Oettgen, Elliot Israel, Lisa Bartnikas, David Kantor, Perdita Permaul, Nicole Akar-Ghibril, Mehtap Haktanir-Abul, Sigfus Gunnalaugsson, Brittany Esty, Elena Crestani, Michelle Maciag, Marissa Hauptman, Sachin N. Baxi, Elizabeth Burke-Roberts, Margee Louisias, Tina Banzon, Saddiq Habiballah, Alan Nguyen, Tregony Simoneau, Samantha Minnicozzi, Elsa Treffeisen, Brenna LaBere, Mia Chandler, Manoussa Fanny, Anna Cristina Vasquez-Muniz, Vanessa Konzelman, Giselle Garcia, Sullivan Waskosky, Anna Ramsey, Ethan Ansel-Kelly, Elizabeth Fitzpatrick, Vaia Bairaktaris, Jesse Fernandez, Brianna Hollister, Owen Lewis, Masai McIntosh, Sigrid Almeida, Carolyn Kercsmar, Karen McDowell, Cassie Shipp, Stephanie (Logsdon) Ward, Nancy Lin, Alisha George, Ryne Simpson, Ina St. Onge, Will Corwin, Grant Geigle, Alisha Hartmann, John Broderick, Stanley Szefler, Naomi Miyazawa, Brooke Tippin, Darci Anderson, Sonya Belimezova, Nidhya Navanandan, Tanya Watson, Michelle Olson, Wanda Caldwell, Caroline Horner, Lila Kertz, Tina Norris, Katherine Rivera-Spoljaric, Andrea Coverstone, Molly McDowell, Sarah Laughlin, Gina Laury, Rosanne Donato, Elizabeth Beckett-Firmage, Elia A. Cornidez, Silvia Lopez, Michele Simon, Raymond Skeps, Monica Vasquez, Rob Gage, Heather Shearer, Melissa Pecak, Sandi Winters, Christine Rukasin, Bernadette McNally, Darcy Johnson, Brian Vickery, Jocelyn Grunwell, Morgan Nicholls, Taqwa El-Hussein, Shilpa Patel, Dinsesh Pillai, Melanie Makhija, Rachel Robison, Jennifer Bosworth, Michelle Catalano, Kathleen Cassin, Laura Bamaca DeLeon, Nicole Titus, Sydney Leibel, Seema Aceves, Diba Mortazavi, Lauren Loop, Sara Anvari, Aikaterini Anagnostou, Kathy Pitts, Sopar Sebutra, Daisy Tran, Chivon McMullen-Jackson, Jay Jin, Nadia Krupp, Clement Ren, Girish Vitalpur, Lori Shively, Patrick Campbell, Lisa Bendy, Lisa France, Sylvia Jara, Sarah Cichy, Linda Engle, Aimee Merchlinski, Melanie Payton, Pam Ramsey, James Schmidt, Dan Tekely, Angela Updegrave, Rachel Weber, Ronald Zimmerman, Nervana Metwali, Xuefang Jing, Melissa Walker, Steven S. Sigelman, Ling Li, and Sanaz Hamrah

Subjects
Allergy, Omalizumab, medicine.disease_cause, Immunoglobulin E, Antibodies, Monoclonal, Humanized, Article, 03 medical and health sciences, 0302 clinical medicine, Immune system, immune system diseases, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Anti-Asthmatic Agents, Risk factor, Child, Sensitization, Asthma, 030505 public health, biology, business.industry, Antibodies, Monoclonal, General Medicine, medicine.disease, respiratory tract diseases, medicine.anatomical_structure, Immunology, biology.protein, Rhinovirus, 0305 other medical science, business, medicine.drug
Abstract

Asthma remains one of the most important challenges to pediatric public health in the US. A large majority of children with persistent and chronic asthma demonstrate aeroallergen sensitization, which remains a pivotal risk factor associated with the development of persistent, progressive asthma throughout life. In individuals with a tendency toward Type 2 inflammation, sensitization and exposure to high concentrations of offending allergens is associated with increased risk for development of, and impairment from, asthma. The cascade of biological responses to allergens is primarily mediated through IgE antibodies and their production is further stimulated by IgE responses to antigen exposure. In addition, circulating IgE impairs innate anti-viral immune responses. The latter effect could magnify the effects of another early life exposure associated with increased risk of the development of asthma – viral infections. Omalizumab binds to circulating IgE and thus ablates antigen signaling through IgE-related mechanisms. Further, it has been shown restore IFN-α response to rhinovirus and to reduce asthma exacerbations during the viral season. We therefore hypothesized that early blockade of IgE and IgE mediated responses with omalizumab would prevent the development and reduce the severity of asthma in those at high risk for developing asthma. Herein, we describe a double-blind, placebo-controlled trial of omalizumab in 2–3 year old children at high risk for development of asthma to prevent the development and reduce the severity of asthma. We describe the rationale, methods, and lessons learned in implementing this potentially transformative trial aimed at prevention of asthma.

Published
2020

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