1. Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects
- Author
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Mine Özcan-Wahlbrink, Christoph Schifflers, and Angelika B. Riemer
- Subjects
0301 basic medicine ,Oncology ,lcsh:Immunologic diseases. Allergy ,medicine.medical_specialty ,HPV-driven HNSCC ,medicine.medical_treatment ,Mini Review ,Cell ,Immunology ,medicine.disease_cause ,Radiation Tolerance ,immune response ,head and neck squamous cell carcinoma (HNSCC) ,03 medical and health sciences ,0302 clinical medicine ,Radiation sensitivity ,Immune system ,stomatognathic system ,Internal medicine ,Radioresistance ,medicine ,otorhinolaryngologic diseases ,Immunology and Allergy ,Animals ,Humans ,Radiosensitivity ,Immune response ,neoplasms ,Papillomaviridae ,Human papillomavirus (HPV) ,business.industry ,Head and neck cancer ,Papillomavirus Infections ,virus diseases ,oropharyngeal squamous cell carcinoma (OPSCC) ,radiation sensitivity ,medicine.disease ,human papillomavirus (HPV) ,Radiation therapy ,stomatognathic diseases ,030104 developmental biology ,medicine.anatomical_structure ,Head and Neck Neoplasms ,business ,Carcinogenesis ,lcsh:RC581-607 ,030215 immunology - Abstract
Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of HPV, HNSCC follow different pathways of carcinogenesis and show distinct clinical presentations regarding survival, prognosis and treatment response. For instance, HPV-driven HNSCC exhibit an enhanced radiation response compared to their typically radioresistant HPV-negative counterparts. Although radiosensitivity of HNSCC has been studied by many research groups, the major causes for the difference in radiation responses between HPV-driven and HPV-negative HNSCC are still an open question. In this mini review, we discuss the reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven HNSCC, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy.
- Published
- 2019