1. Clinical and magnetic resonance study of a case of subacute sclerosing panencephalitis treated with ketogenic diet
- Author
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Christian Lettieri, Riccardo Garbo, Andrea Bernardini, Mariarosaria Valente, Ilaria Del Negro, Davide Pecori, Maria Rosaria Peri, Daniele Bagatto, Annacarmen Nilo, and Gian Luigi Gigli
- Subjects
0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Central nervous system ,Short Report ,Neurosciences. Biological psychiatry. Neuropsychiatry ,infectious diseases ,Neuroprotection ,Subacute sclerosing panencephalitis ,Measles virus ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Magnetic resonance study ,clinical neurology ,Adverse effect ,MR ,biology ,business.industry ,Patient affected ,medicine.disease ,biology.organism_classification ,030104 developmental biology ,medicine.anatomical_structure ,Neurology ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Ketogenic diet ,RC321-571 - Abstract
BackgroundSubacute sclerosing panencephalitis is a progressive neurodegenerative disorder caused by a latent and mutant measles virus which is extremely rare in developed countries. The lack of effective treatments leads to the research of other anti-inflammatory and neuroprotective treatments.CaseHere we present a case of a 17-year-old patient affected by subacute sclerosing panencephalitis who manifest a dramatic improvement in neurological and general clinical conditions, as well as an arrest in the progression of demyelinating process in the central nervous system, after the beginning of a high ratio ketogenic diet.ConclusionsGiven its anti-inflammatory, antioxidant and metabolic effects, we believe that ketogenic diet utilisation could be a rational approach, can be considered a safe add-on therapy, carrying on with only a minimal risk of adverse effects or interactions.
- Published
- 2021