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1. Association between ACTN3 R577X genotype and risk of non-contact injury in trained athletes: A systematic review

Author: Juan Del Coso, Hassane Zouhal, Guillaume Ravé, Claire Tourny, Abderraouf Ben Abderrahman, Benjamin Barthélémy, Nidhal Jebabli, Cain C T Clark, Anthony C. Hackney, Ayyappan Jayavel, Laboratoire Mouvement Sport Santé (M2S), École normale supérieure - Cachan (ENS Cachan)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Universidad Rey Juan Carlos [Madrid] (URJC), SRM Institute of Science and Technology (SRM), Centre d’études des transformations des activités physiques et sportives (CETAPS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Toulouse Football Club, ISSEP Ksar Saïd, Université de la Manouba [Tunisie] (UMA), Coventry University, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), and Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: medicine.medical_specialty, [SDV]Life Sciences [q-bio], Physical Therapy, Sports Therapy and Rehabilitation, Single-nucleotide polymorphism, Athletic performance, 03 medical and health sciences, 0302 clinical medicine, Polymorphism (computer science), Internal medicine, Epidemiology, Genotype, medicine, Muscle injury, Orthopedics and Sports Medicine, Exercise-related injury, Association (psychology), α-actinin-3 deficiency, 030304 developmental biology, 0303 health sciences, biology, business.industry, Athletes, 030229 sport sciences, biology.organism_classification, Single nucleotide polymorphism, medicine.anatomical_structure, Ankle, business, XX Genotype
Abstract: Background The aim of this study was to review, systematically, evidence concerning the link between the ACTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training programs. Methods A computerized literature search was performed in the electronic databases PubMed, Web of Science, and SPORTDiscus, from inception until November 2020. All included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the ACTN3 R577X polymorphism. Results Our search identified 492 records. After the screening of titles, abstracts, and full texts, 13 studies examining the association between the ACTN3 genotypes and the rate and severity of non-contact injury were included in the analysis. These studies were performed in 6 different countries (Spain, Japan, Brazil, China, Republic of Korea, and Italy) and involved a total participant pool of 1093 participants. Of the studies, 2 studies involved only women, 5 studies involved only men, and 6 studies involved both men and women. All the studies included were classified as high-quality studies (≥6 points in the Physiotherapy Evidence Database (PEDro) scale score). Overall, evidence suggests there is an association between the ACTN3 R577X genotype and non-contact injury in 12 investigations. Six studies observed a significant association between ACTN3 R577X polymorphism and exercise induced muscle damage: two with non-contact ankle injury, three with non-contact muscle injury, and one with overall non-contact injury. Conclusion The present findings support the premise that possessing the ACTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries, such as muscle injury, ankle sprains, and higher levels of exercise-induced muscle damage.
Published: 2023
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2. L’activité principale à distance en période de COVID-19 : quel impact ?

Author: J Corruble, Amine Rezrazi, T Plaie, B. Gouvernet, Centre de Recherches sur les Fonctionnements et Dysfonctionnements Psychologiques (CRFDP), Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), and Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS)
Subjects: Coronavirus disease 2019 (COVID-19), business.industry, Period (gene), Teleworking, MEDLINE, COVID-19, [SHS.PSY]Humanities and Social Sciences/Psychology, Article, Job Satisfaction, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Arts and Humanities (miscellaneous), Humans, Medicine, Workplace, business, ComputingMilieux_MISCELLANEOUS, 030217 neurology & neurosurgery, Demography
Abstract: International audience
Published: 2022
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3. Impact of COVID-19 pandemic on functional urology procedures in France: a prospective study

Author: C. Guillot-Tantay, Pierre-Luc Dequirez, Xavier Gamé, Grégoire Robert, Charles Joussain, Alain Ruffion, Benoit Peyronnet, Gilles Karsenty, Sypre Davidson, Jeanne Simon, Véronique Phé, Vassily Anastay, Lucie Vangheluwe, Raphael Fleury, Jean-Nicolas Cornu, Pierre-Vincent Campello, Marie-Aimée Perrouin-Verbe, Maximilien Baron, Tiffany Cousin, Astrid Balanca, Priscilla Léon, Xavier Biardeau, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Bordeaux [Bordeaux], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), CHU Toulouse [Toulouse], Centre hospitalier universitaire de Nantes (CHU Nantes), Service d'urologie [Rennes] = Urology [Rennes], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Hôpital Claude Huriez [Lille], CHU Lille, Service d'urologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Service Urologie, Clinique Pasteur, Paris, France., Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and douville, sabine
Subjects: Adult, Male, Urologic Diseases, medicine.medical_specialty, 2019-20 coronavirus outbreak, Time Factors, Referral, Coronavirus disease 2019 (COVID-19), Urology, Urinary incontinence, 030232 urology & nephrology, Psychological intervention, Functional urology, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Time-to-Treatment, 03 medical and health sciences, 0302 clinical medicine, Primary outcome, Pandemic, medicine, Humans, Prospective Studies, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, Aged, SARS-CoV-2, business.industry, Patient Selection, COVID-19, Middle Aged, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 3. Good health, 030220 oncology & carcinogenesis, Communicable Disease Control, Urologic Surgical Procedures, Female, Original Article, France, Triage, medicine.symptom, business
Abstract: Purpose To evaluate the impact of COVID-19 pandemic on functional urology procedures in France. Methods A prospective study was conducted within 11 secondary and tertiary referral centers in France. Patients aged > 18 years who were diagnosed with a functional urology disease before the national lockdown (March 17th, 2020) and who required a surgery were included. Study period went from March 17th to September 30th 2020. The included interventions were listed according to the guidelines for functional urology enacted by the French Association of Urology and delay of reoperation was compared to the guidelines’ delay. The primary outcome was the number of procedures left unscheduled at the end of the study period. Descriptive statistics were performed. Results From March 17th 2020 to September 3 rd 2020, 1246 patients with a previous diagnosis of a functional urological disease requiring a surgery were included. The mean follow-up was 140.4 days (± 53.4). Overall, 316 interventions (25.4%) were maintained whereas 74 (5.9%) were canceled, 848 (68.1%) postponed and 8 patients (0.6%) died. At the end of the follow-up, 184 patients (21.7%) were still not rescheduled. If the intervention was postponed, the mean delay between the initial and final date was 85.7 days (± 64.4). Conclusion Overall, more than two thirds of interventions had to be postponed and the mean delay between the initial and final date was about three months.
Published: 2021
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4. Supportive care in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis

Author: Neil H. Shear, P. Joly, Alain Brassard, P. Wolkenstein, Kanade Shinkai, L. S. Vidal, K. Zaghbib, C. Salavastru, J. Newman, A. Colin, J.N. Bouwes Bavinck, N. Hama, Arturo R. Dominguez, J. T. Schulz, Roni P. Dodiuk-Gad, Lars E. French, Emanual Michael Maverakis, D. Meyersburg, Chia-Yu Chu, K. Pallesen, M. C. Brüggen, R. Le Floch, Robert G. Micheletti, E. Bequignon, B. Milpied, Tetsuo Shiohara, Benjamin H. Kaffenberger, Paolo Romanelli, C. Bodemer, S. L. Chua, Arash Mostaghimi, E. Howard, Elizabeth J. Phillips, Annamari Ranki, Mirjam Nägeli, R. Sheridan, J. Gueudry, S. Ingen-Housz-Oro, Barbara Horváth, A. Toussi, Amy S. Paller, Jonathan Cotliar, Anette Bygum, Danielle M. Tartar, N. de Prost, Robert S. Stern, S. Walsh, Wen-Hung Chung, Scott Worswick, Riichiro Abe, M. Arden-Jones, Megan H. Noe, C. Moss, George-Sorin Tiplica, E. Brezinova, B. Didona, S. T. Le, Hôpital Henri Mondor, Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle (ESCAPE), Université de Reims Champagne-Ardenne (URCA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, Helsinki University Hospital Area, University of Helsinki, Translational Immunology Groningen (TRIGR), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)-Normandie Université (NU)-Université de Reims Champagne-Ardenne (URCA)
Subjects: Adult, medicine.medical_specialty, Consensus, education, MEDLINE, Dermatology, Phase (combat), 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Multidisciplinary approach, Humans, Medicine, Infection control, Child, Retrospective Studies, computer.programming_language, Modalities, business.industry, Research, Stevens johnson, 16. Peace & justice, medicine.disease, Toxic epidermal necrolysis, 3. Good health, Stevens-Johnson Syndrome, 3121 General medicine, internal medicine and other clinical medicine, Family medicine, business, computer, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, Delphi
Abstract: Background Supportive care is the cornerstone of management of adult and paediatric Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, consensus on the modalities of supportive care is lacking.Objectives Our aim in this international multicentric Delphi exercise was to establish a multidisciplinary expert consensus to standardize recommendations regarding supportive care in the acute phase of SJS/TEN.Methods Participants were sent a survey via the online tool SurveyMonkey, consisting of 103 statements organized into 11 topics: multidisciplinary team composition, suspect drug management, infection prevention, fluid resuscitation and prevention of hypothermia, nutritional support, pain and psychological distress management, management of acute respiratory failure, local skincare, ophthalmological management, management of other mucosa, and additional measures. Participants evaluated the level of appropriateness of each statement on a scale of 1 (extremely inappropriate) to 9 (extremely appropriate). The results were analysed according to the RAND/UCLA Appropriateness Method.Results Forty-five participants from 13 countries (on three continents) participated. After the first round, a consensus was obtained for 82.5% of the 103 initially proposed statements. After the second round, a final consensus was obtained for 102 statements.Conclusions We have reached an international Delphi-based consensus on best supportive care practice for SJS/TEN. Our expert consensus should help guide physicians in treating patients with SJS/TEN and thereby improve short-term prognosis and the risk of sequelae.
Published: 2021
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5. Monte Carlo transport of swift protons and light ions in water: The influence of excitation cross sections, relativistic effects, and Auger electron emission in w-values

Author: Michael Beuve, Veronica Tessaro, Floriane Poignant, M E Galassi, Benoit Gervais, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Proton, Astrophysics::High Energy Astrophysical Phenomena, Monte Carlo method, Biophysics, General Physics and Astronomy, Electrons, Electron, 030218 nuclear medicine & medical imaging, Ion, Auger, 03 medical and health sciences, 0302 clinical medicine, Stopping power (particle radiation), Radiology, Nuclear Medicine and imaging, Ions, [PHYS]Physics [physics], Physics, Auger electron spectroscopy, Reproducibility of Results, Water, General Medicine, 030220 oncology & carcinogenesis, Protons, Atomic physics, Relativistic quantum chemistry, Monte Carlo Method
Abstract: Purpose To develop a particle transport code to compute w-values and stopping power of swift ions in liquid water and gases of interest for reference dosimetry in hadrontherapy. To analyze the relevance of inelastic and post-collisional processes considered. Methods The Monte Carlo code MDM was extended to the case of swift ion impact on liquid water (MDM-Ion). Relativistic corrections in the inelastic cross sections and the post-collisional Auger emission were considered. The effects of introducing different electronic excitation cross sections were also studied. Results The stopping power of swift ions on liquid water, calculated with MDM-Ion, are in excellent agreement with recommended data. The w-values show a strong dependence on the electronic excitation cross sections and on the Auger electron emission. Comparisons with other Monte Carlo codes show the relevance of both the processes considered and of the cross sections employed. W and w-values for swift electron, proton, and carbon ions calculated with the MDM and MDM-Ion codes are in very close agreement with each other and with the 20.8 eV experimental value. Conclusion We found that w-values in liquid water are independent of ion charge and energy, as assumed in reference dosimetry for hadrontherapy from sparse experimental results for electron and ion impact on gases. Excitation cross sections and Auger emission included in Monte Carlo codes are critical in w-values calculations. The computation of this physical parameter should be used as a benchmark for micro-dosimetry investigations, to assess the reliability of the cross sections employed.
Published: 2021
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6. Transcorporal vs. bulbar artificial urinary sphincter implantation in male patients with fragile urethra

Author: Franck Bruyère, T. Tricard, Pierre Lecoanet, Baptiste Poussot, Nicolas Hermieu, Alain Ruffion, Victor Gaillard, Hervé Monsaint, Grégoire Capon, Christian Saussine, Xavier Biardeau, Damien Robin, Daniel Chevallier, L. Corbel, Thibaut Brierre, Alice Pitout, Priscilla Bertrand-Leon, Jean-Nicolas Cornu, Benoit Peyronnet, Mehdi El-Akri, Hugo Dupuis, Xavier Gamé, I. Bentellis, Tiffany Cousin, Jean-François Hermieu, Florian Beraud, CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Strasbourg, Centre Hospitalier Universitaire Toulouse (CHU Toulouse), CHU Bordeaux [Bordeaux], Service d'urologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service d’urologie, hôpital Bichat-Claude-Bernard, Hôpitaux Universitaires Paris Nord Val de Seine, Centre Hospitalier Universitaire de Reims (CHU Reims), Service d'Urologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service d'Urologie, andrologie et transplantation rénale [CHRU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Clinique Oceane, Vannes, Clinique Plérin, Plérin, Service d'urologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), CHU Toulouse [Toulouse], and Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, medicine.medical_specialty, Urethral stricture, Urology, Population, 030232 urology & nephrology, Urinary incontinence, Risk Assessment, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Prosthesis Implantation, Artificial urinary sphincter, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, medicine, Humans, Risk factor, education, Device Removal, ComputingMilieux_MISCELLANEOUS, Aged, Retrospective Studies, Aged, 80 and over, education.field_of_study, business.industry, Urethral sphincter, Middle Aged, medicine.disease, Surgery, Urethra, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cuff, Urinary Sphincter, Artificial, medicine.symptom, business
Abstract: To compare transcorporal vs bulbar artificial urinary sphincter (AUS) implantation in men with fragile urethra and to investigate the risk factors of AUS explantation in this population. The charts of all male patients who had an AUS implantation between 2004 and 2020 in 16 centers were reviewed retrospectively. The primary endpoint was device explantation-free survival. Only patients with a fragile urethra were included in the present analysis. Fragile urethra was defined as a urethra carrying a high risk of cuff erosion because of prior radiotherapy and/or history of AUS explantation and/or history of urethral stricture surgery. The patients were divided in two groups according to the implantation site: bulbar vs transcorporal. 464 patients were included for analysis. 88 patients underwent a transcorporal AUS implantation and 376 underwent a bulbar AUS implantation. Explantation-free survival was similar in both groups (estimated 5-year explantation free survival rates 55.3% vs. 58.4%; p=0.98). In the subgroup of patients with a history of previous AUS explantation, transcorporal approach tended to bring longer explantation-free survival (2-year explantation-free survival: 61.9% vs. 58.2%; p=0.096). In multivariate analysis, the only risk factor of shorter explantation-free survival was the history of previous AUS explantation (HR=2.65; p=0.01). Transcorporal AUS implantation was not associated with longer explantation-free survival. History of previous AUS explantation was the only risk factor associated with shorter explantation-free survival and this subgroup of patients may be the only one to draw benefits of transcorporal AUS implantation.
Published: 2021
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7. CEA, CA19-9, circulating DNA and circulating tumour cell kinetics in patients treated for metastatic colorectal cancer (mCRC)

Author: David Sefrioui, Ludivine Beaussire, André Gillibert, France Blanchard, Emmanuel Toure, Céline Bazille, Anne Perdrix, Frédéric Ziegler, Alice Gangloff, Mélanie Hassine, Caroline Elie, Anne-Laure Bignon, Aurélie Parzy, Philippe Gomez, Caroline Thill, Florian Clatot, Jean-Christophe Sabourin, Thierry Frebourg, Jacques Benichou, Karine Bouhier-Leporrier, Marie-Pierre Gallais, Nasrin Sarafan-Vasseur, Pierre Michel, Frédéric Di Fiore, Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU), Unité de biostatistiques [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Département de Pathologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Laboratoire de biochimie générale [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre hospitalier universitaire de Rouen, Hepatogastroenterologie, chu Elbeuf Les Feugrais, Hepatogastroenterology, Caen University Hospital, Caen., Department of Hepatogastroenterology, Caen University Hospital, Departement Hepatogastroenterologie, Centre Francois Baclesse, Caen, Medical Oncology, centre Frédéric Joliot, Département de génétique [CHU Rouen] (Centre Normandie de Génomique et de Médecine Personnalisée), Service d'Hépato-Gastroentérologie [CHU Rouen], and Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN)
Subjects: Adult, Male, Cell kinetics, Oncology, Cancer Research, medicine.medical_specialty, Scoring system, endocrine system diseases, Colorectal cancer, medicine.medical_treatment, Article, Circulating Tumor DNA, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Humans, Antigens, Tumor-Associated, Carbohydrate, In patient, Prospective Studies, Neoplasm Metastasis, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, Chemotherapy, business.industry, Middle Aged, Neoplastic Cells, Circulating, medicine.disease, Survival Analysis, digestive system diseases, Carcinoembryonic Antigen, Up-Regulation, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Circulating DNA, Female, CA19-9, Colorectal Neoplasms, business, Progressive disease
Abstract: BACKGROUND: We previously reported that CEA kinetics are a marker of progressive disease (PD) in metastatic colorectal cancer (mCRC). This study was specifically designed to confirm CEA kinetics for predicting PD and to evaluate CA19-9, cell-free DNA (cfDNA), circulating tumour DNA (ctDNA) and circulating tumour cell (CTC) kinetics. METHODS: Patients starting a chemotherapy (CT) with pre-treatment CEA > 5 ng/mL and/or CA19.9 > 30 UI/mL were prospectively included. Samples were collected from baseline to cycle 4 for CEA and CA19-9 and at baseline and the sixth week for other markers. CEA kinetics were calculated from the first to the third or fourth CT cycle. RESULTS: A total of 192 mCRC patients were included. CEA kinetics based on the previously identified >0.05 threshold was significantly associated with PD (p
Published: 2021
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8. A Systematic Review of Patients’ Values, Preferences, and Expectations for the Diagnosis and Treatment of Male Lower Urinary Tract Symptoms

Author: Gordon H. Guyatt, Lyubov Lytvyn, Stavros Gravas, Marcus J. Drake, Jean-Nicholas Cornu, M. Speakman, Jessica R. Wheeler, Thomas R. W. Herrmann, Roland Umbach, Mauro Gacci, Charalampos Mamoulakis, Sachin Malde, Christian Gratzke, Malte Rieken, Kari A.O. Tikkinen, Department of Urology, Guy's and St Thomas' NHS Foundation Trust, Department of Urology, Klinikum Sindelfingen-Bӧblingen, University of Bristol [Bristol], Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service d'urologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, University of Florence, Department of Urology, University Hospital Freiburg, Department of Urology, Kantonsspital Frauenfeld, Department of Urology, University General Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece., University of Basel, Department of Urology, Taunton & Somerset Hospital, Department of Urology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece., Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada, Department of Medicine, McMaster University, and University of Helsinki
Subjects: medicine.diagnostic_test, business.industry, Urinary retention, Urology, 030232 urology & nephrology, Context (language use), Guideline, medicine.disease, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Lower urinary tract symptoms, 030220 oncology & carcinogenesis, medicine, Nocturia, Urodynamic testing, medicine.symptom, business, Grading (education), ComputingMilieux_MISCELLANEOUS, Clinical psychology, Qualitative research
Abstract: Context Understanding men’s values and preferences in the context of personal, physical, emotional, relational, and social factors is important in optimising patient counselling, facilitating treatment decision-making, and improving guideline recommendations. Objective To systematically review the available evidence regarding the values, preferences, and expectations of men towards the investigation and treatment (conservative, pharmacological, and surgical) of male lower urinary tract symptoms (LUTS). Evidence acquisition We searched electronic databases until August 31, 2020 for quantitative and qualitative studies that reported values and preferences regarding the investigation and treatment of LUTS in men. We assessed the quality of evidence and risk of bias using the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) and GRADE Confidence in the Evidence from Reviews of Qualitative Research (CERQual) approaches. Evidence synthesis We included 25 quantitative studies, three qualitative studies, and one mixed-methods study recruiting 9235 patients. Most men reported urodynamic testing to be acceptable, despite discomfort or embarrassment, as it significantly informs treatment decisions (low certainty evidence). Men preferred conservative and less risky treatment options, but the preference varied depending on baseline symptom severity and the risk/benefit characteristics of the treatment (moderate certainty). Men preferred pharmacological treatments with a low risk of erectile dysfunction and those especially improving urgency incontinence (moderate certainty). Other important preference considerations included reducing the risk of acute urinary retention or surgery (moderate certainty). Conclusions Men prefer lower-risk management options that have fewer sexual side effects and are primarily effective at improving urgency incontinence and nocturia. Overall, the evidence was rated to be of low to moderate certainty. This review can facilitate the treatment decision-making process and improve the trustworthiness of guideline recommendations. Patient summary We thoroughly reviewed the evidence addressing men’s values and preferences regarding the management of urinary symptoms and found that minimising adverse effects is particularly important. Further research to understand other factors that matter to men is required.
Published: 2021
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9. Role of microbiota-gut-brain axis dysfunctions induced by infections in the onset of anorexia nervosa

Author: Najate Achamrah, Pierre Déchelotte, Marie Galmiche, D. Ribet, Jonathan Breton, Service de nutrition [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), and Normandie Université (NU)-Normandie Université (NU)
Subjects: 0301 basic medicine, Anorexia Nervosa, media_common.quotation_subject, Gut–brain axis, Medicine (miscellaneous), Gut flora, 03 medical and health sciences, 0302 clinical medicine, Brain-Gut Axis, medicine, Humans, media_common, 2. Zero hunger, Nutrition and Dietetics, biology, business.industry, digestive, oral, and skin physiology, Appetite, medicine.disease, biology.organism_classification, Gastrointestinal Microbiome, 3. Good health, Eating disorders, 030104 developmental biology, Phobic Disorders, Mood disorders, Anorexia nervosa (differential diagnoses), Immunology, Dysbiosis, Intestinal Disorder, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery
Abstract: Anorexia nervosa (AN) is an eating disorder characterized by low food intake, severe body weight loss, intense fear of gaining weight, and dysmorphophobia. This chronic disease is associated with both psychiatric and somatic comorbidities. Over the years, clinical studies have accumulated evidence that viral or bacterial infections may promote the onset of eating disorders such as AN. This review aims to describe how infections and the subsequent immune responses affect food intake regulation in the short term and also how these processes may lead to long-term intestinal disorders, including gut barrier disruption and gut microbiota dysbiosis, even after the clearance of the pathogens. We discuss in particular how infection-mediated intestinal dysbiosis may promote the onset of several AN symptoms and comorbidities, including appetite dysregulation, functional gastrointestinal disorders, and mood disorders.
Published: 2021
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10. Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice

Author: Quentin Delarue, Romane Massardier, Amandine Robac, Jean-Paul Marie, Nicolas Guérout, Groupe de Recherche sur le Handicap Ventilatoire (GRHV), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Delarue, Quentin
Subjects: RRID:AB_306827: p75, Abcam, ab8874, RRID:AB_839504: Iba1, Wako, 019‐19741, 0301 basic medicine, MRG2b-85, Cell Transplantation, 712-165-153, RRID:AB_2340667: Jackson ImmunoResearch, Stimulation, RRID:AB_2313568: Jackson ImmunoResearch, RRID:AB_777165:P DGFRβAbcam ab32570, Pharmacology, RRID:AB_306827: p75, RRID:AB_94975: MBP, Millipore, MAB386, Mice, Random Allocation, RRID:AB_2340812: Jackson ImmunoResearch, 0302 clinical medicine, Neural Stem Cells, Fibrosis, RRID:AB_476889: GFAP Cy3‐conjugated Sigma‐Aldrich, C9205, RRID:AB_2715913: Alexa 488, RRID:AB_2340667: Jackson ImmunoResearch, 712‐165‐153, RRID:AB_10643424: PE, GFP)L2G85Chco/J), Spinal cord injury, Research Articles, RRID:AB_10563302: PDGFRβ, MAB386, RRID:AB_2340812: Jackson ImmunoResearch, 715‐165‐140, RRID:AB_10643424: PE, poly4064, BioLegend, 406408, Wako, Olfactory Bulb, Transcranial Magnetic Stimulation, RRID:AB_476889: GFAP Cy3-conjugated Sigma-Aldrich, Microglial cell activation, Abcam, RRID:IMSR_JAX:008450: L2G85Chco+/+ (FVB-Tg(CAG-luc, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, glial scar, RRID:IMSR_JAX:008450: L2G85Chco+/+ (FVB‐Tg(CAG‐luc,‐GFP)L2G85Chco/J), Research Article, RRID:AB_2715913: Alexa 488, MRG2b‐85, BioLegend, C9205, RRID:AB_2313568: Jackson ImmunoResearch, 711‐166‐152, [SDV.IMM] Life Sciences [q-bio]/Immunology, RRID:AB_10563302: PDGFRβ, Abcam, ab91066, 711-166-152, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, rehabilitation, Glial scar, 03 medical and health sciences, Cellular and Molecular Neuroscience, 019-19741, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, poly4064, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], BioLegend, ab8874, RRID:AB_94975: MBP, magnetic stimulation, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Spinal Cord Injuries, business.industry, RRID:AB_839504: Iba1, Recovery of Function, 715-165-140, medicine.disease, ab91066, Neuroregeneration, spinal cord injury, Nerve Regeneration, Mice, Inbred C57BL, Transplantation, 030104 developmental biology, Millipore, Olfactory ensheathing glia, business, olfactory ensheathing cells and neuroregeneration, 030217 neurology & neurosurgery
Abstract: Spinal cord injury (SCI) is a debilitating condition, which leads to a permanent loss of functions below the injury site. The events which take place after SCI are characterized by cellular death, release of inhibitory factors, and inflammation. Many therapies have been studied to cure SCI, among them magnetic stimulation aims to reduce the secondary damages in particular by decreasing apoptosis, while, cellular transplantation promotes neuroregeneration by enhancing axonal regrowth. In the present study, we compared individually primary olfactory ensheathing cell (OEC) transplantation and repetitive trans‐spinal magnetic stimulation (rTSMS) and then, we combined these two therapeutic approaches on tissue repair and functional recovery after SCI. To do so, SCIs were performed at Th10 level on female C57BL/6 mice, which were randomized into four groups: SCI, SCI + primary bOECs, SCI + STM, SCI + primary bulbar olfactory ensheathing cells (bOECs) + stimulation (STM). On these animals bioluminescence, immunohistological, and behavioral experiments were performed after SCI. Our results show that rTSMS has beneficial effect on the modulation of spinal scar by reducing fibrosis, demyelination, and microglial cell activation and by increasing the astroglial component of the scar, while, primary bOEC transplantation decreases microglial reactivity. At the opposite, locotronic experiments show that both treatments induce functional recovery. We did not observed any additional effect by combining the two therapeutic approaches. Taken together, the present study indicates that primary bOEC transplantation and rTSMS treatment act through different mechanisms after SCI to induce functional recovery. In our experimental paradigm, the combination of the two therapies does not induce any additional benefit., Summary of the main results of the study.
Published: 2021
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11. Beyond Antimuscarinics: A Review of Pharmacological and Interventional Options for Overactive Bladder Management in Men

Author: Jean-Nicolas Cornu, Cosimo De Nunzio, Ferdinando Fusco, Benjamin M. Brucker, Marcus J. Drake, Matthias Oelke, Benoit Peyronnet, Stavros Gravas, Stephan Madersbacher, Gommert van Koeveringe, Thomas Bschleipfer, Manuela Tutolo, Urology Unit, Ospedale Sant'Andrea, Sapienza University of Rome, New York University Langone Health, Clinic for Urology, Andrology and Pediatric Urology, Clinics of Nordoberpfalz AG, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service d'urologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), University of Bristol [Bristol], Urology Unit, University of Campania L. Vanvitelli, Department of Urology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece., Department of Urology, Pediatric Urology & Urological Oncology, St. Antonius Hospital, CHU Pontchaillou [Rennes], Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy., Department of Urology, Maastricht University Medical Center, and Department of Urology, Clinic Favoriten and Sigmund Freud Private University
Subjects: medicine.medical_specialty, Urology, Population, 030232 urology & nephrology, Context (language use), BENIGN PROSTATIC HYPERPLASIA, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, law.invention, 03 medical and health sciences, Antimuscarinics, DOUBLE-BLIND, 0302 clinical medicine, Randomized controlled trial, law, QUALITY-OF-LIFE, Internal medicine, medicine, antimuscarinics, lower urinary tract symptoms, men, overactive bladder, Nocturia, MIRABEGRON, Lower urinary tract symptoms, education, ComputingMilieux_MISCELLANEOUS, TRANSURETHRAL RESECTION, education.field_of_study, business.industry, Overactive bladder, URINARY-TRACT SYMPTOMS, Men, Evidence-based medicine, medicine.disease, EFFICACY, 3. Good health, DETRUSOR OVERACTIVITY, Systematic review, STORAGE SYMPTOMS, 030220 oncology & carcinogenesis, SAFETY, medicine.symptom, Mirabegron, business, medicine.drug
Abstract: Context: The role of overactive bladder (OAB) treatment in women beyond antimuscarinics has been evaluated extensively. Beta-3 agonists, botulinum toxin-A (BTX-A), and nerve stimulation are indicated in these patients. However, data on male patients in this clinical scenario are scarce.Objective: The aim of this systematic review was to evaluate the evidence on treatment options beyond antimuscarinics in men with OAB.Evidence acquisition: A search of PubMed, EMBASE, Scopus, Web of science, Cochrane Central Register of Controlled Trials, and Cochrane Central Database of Systematic Reviews databases was performed for relevant articles published between January 2000 and October 2020, using the following Medical Subject Headings: "male/man," "LUTS," "overactive bladder," "storage symptoms," "urgency," "nocturia," "incontinence," "beta-3 agonist," "PDE-5 inhibitors," "botulinum toxin," "sacral nerve stimulation/neurostimulation," "percutaneous/transcutaneous tibial nerve stimulation," "PTENS," and "combination therapy." Evidence acquisition was performed according to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. PROSPERO registration number is CRD42020201223.Evidence synthesis: Overall, 24 studies were retrieved. In male OAB, mirabegron (MIRA) is the most intensively investigated pharmacological option. A pooled analysis of five randomized clinical trials (RCTs), including 1187 patients, concluded that MIRA 50 mg was associated with a greater reduction in frequency versus placebo (-0.37, 95% confidence interval [CI]: -0.74, -0.01, p < 0.05). A pooled analysis of three RCTs, including 1317 male patients, has also shown that the addition of MIRA 50 mg in men receiving the alpha(1)-blocker tamsulosin improved the mean number of micturitions per day (-0.27, 95% CI: -0.46 to -0.09, p < 0.05), urgency episodes (-0.50, 95% CI: -0.77 to -0.22, p < 0.05), total OAB symptom score (-0.66, 95% CI: -1.00 to -0.38, p < 0.05), and mean volume voided (+10.76 ml, 95% CI: 4.87-16.64, p < 0.05). MIRA treatment is well tolerated in men. Other pharmacological treatment options, such as phosphodiesterase-5 (PDE-5) inhibitors, should be considered investigational. BTX-A seems to be effective as third-line treatment in male OAB patients. A higher rate of intermittent self-catheterization (5-42%) is observed in male than in female patients. Data on nerve stimulation are scarce.Conclusions: MIRA has the most robust data in terms of safety and efficacy in this patient population. Preliminary data in men suggest that BTX-A is indicated as an interventional treatment. Evidence for PDE-5 inhibitors and nerve stimulation is too limited to provide recommendations. Future studies in this population should aim to better define the best treatment sequence and to identify predictors for treatment response and failure, to determine a therapeutic approach tailored to patients' characteristics.Patient summary: Overactive bladder is highly prevalent in men. Mirabegron 50 mg is the treatment option supported by the highest level of evidence when antimuscarinics failed. Botulinum toxin A injections seems to be an effective treatment as interventional option. Roles of nerve stimulation and phosphodiesterase inhibitors in male OAB patients are still to be defined. (C) 2020 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Published: 2021
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12. Rencontre entre chercheures et professionnels d’un Programme de Réussite Éducative : le partage d’une altérité professionnelle, un engagement dans la confiance

Author: Julie Delalande, Nathalie Dupont, Centre interdisciplinaire de recherche normand en éducation et formation (CIRNEF), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), and Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN)
Subjects: 03 medical and health sciences, 0302 clinical medicine, Developmental and Educational Psychology, 030210 environmental & occupational health, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences, Education
Abstract: Nous sommes deux chercheures du CIRNEF (Centre Interdisciplinaire de Recherches Normand en Education et Formation) de l’Universite de Caen Normandie qui avons travaille pendant cinq ans avec des professionnels d’un Programme de Reussite Educative. A partir d’un ensemble d’actions partagees, initiees par une demande de formation, nous avons tisse des relations qui nous ont amenees a partager notre alterite professionnelle et a rapprocher nos deux mondes professionnels. C’est le recit de cette implication que nous proposons, qui par son analyse vise a contribuer aux reflexions qui animent les chercheurs sur leurs relations avec les personnes qu’ils cotoient, dans le cadre d’une recherche ou d’une formation. Ni recherche, ni formation, ni recherche-action, l’investissement decrit ici defend le statut de chercheurs de proximite qui s’inscrivent dans la tradition anthropologique de la rencontre et aussi dans une forme hybride entre intervention, accompagnement, partenariat et recherche.
Published: 2021
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13. The centenary of the Harris–Benedict equations: How to assess energy requirements best? Recommendations from the ESPEN expert group

Author: Eric Fontaine, Marian A. E. de van der Schueren, Alessandro Laviano, Claude Pichard, Pierre Singer, Michael Hiesmayr, Dileep N. Lobo, Moïse Coëffier, Itai Bendavid, Tommy Cederholm, Rocco Barazzoni, Tel Aviv University [Tel Aviv], Gastrointestinal Surgery, Nottingham Digestive Diseases Centre, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy., Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden, Theme Ageing, Karolinska University Hospital, Stockholm, Sweden., Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de nutrition [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Nutrition and Dietetics, HAN University of Applied Sciences, School of Allied Health, Nijmegen, the Netherlands., Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Division of Cardiac, Thoracic, Vascular Anesthesia and Intensive Care Medicine, Medical University of Vienna, Waehringerguertel 18-20, 1090 Vienna, Austria., Department of Translational and Precision Medicine, Sapienza University, Rome, Italy., Clinical Nutrition, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland., Department of General Intensive Care and Institute for Nutrition Research, Rabin Medical Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv, Bendavid, I., Lobo, D. N., Barazzoni, R., Cederholm, T., Coeffier, M., de van der Schueren, M., Fontaine, E., Hiesmayr, M., Laviano, A., Pichard, C., Singer, P., douville, sabine, Tel Aviv University (TAU), Università degli studi di Trieste = University of Trieste, Uppsala University, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Charles Nicolle [Rouen], and Normandie Université (NU)-Normandie Université (NU)-CHU Rouen
Subjects: Male, 0301 basic medicine, Critical Illness, Energy (esotericism), Energy requirement, 030209 endocrinology & metabolism, Indirect calorimetry, Energy expenditure, Energy requirements, Nutritional prescriptions, Predictive equations, Critical Care and Intensive Care Medicine, Nutrition Policy, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Neoplasms, Humans, Medicine, Obesity, Medical prescription, Aged, ddc:616, Estimation, Nutritional prescription, 030109 nutrition & dietetics, Nutrition and Dietetics, Actuarial science, business.industry, Harris–Benedict equation, Body Weight, Nutritional Requirements, Calorimetry, Indirect, Expert group, 3. Good health, Variety (cybernetics), [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Surgical Procedures, Operative, Body Constitution, Female, Basal Metabolism, Energy Intake, Energy Metabolism, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Background & aims: The year 2019 marked the centenary of the publication of the Harris and Benedict equations for estimation of energy expenditure. In October 2019 a Scientific Symposium was organized by the European Society for Clinical Nutrition and Metabolism (ESPEN) in Vienna, Austria, to celebrate this historical landmark, looking at what is currently known about the estimation and measurement of energy expenditure. Methods: Current evidence was discussed during the symposium, including the scientific basis and clinical knowledge, and is summarized here to assist with the estimation and measurement of energy requirements that later translate into energy prescription. Results: In most clinical settings, the majority of predictive equations have low to moderate performance, with the best generally reaching an accuracy of no more than 70%, and often lead to large errors in estimating the true needs of patients. Generally speaking, the addition of body composition measurements did not add to the accuracy of predictive equations. Indirect calorimetry is the most reliable method to measure energy expenditure and guide energy prescription, but carries inherent limitations, greatly restricting its use in real life clinical practice. Conclusions: While the limitations of predictive equations are clear, their use is still the mainstay in clinical practice. It is imperative to recognize specific patient populations for whom a specific equation should be preferred. When available, the use of indirect calorimetry is advised in a variety of clinical settings, aiming to avoid under-as well as overfeeding. (C)2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Published: 2021
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14. Effects of corticosterone injections in mid-to-late mouse postnatal development on adult motor activity and coordination

Author: Magali Hernandez, Robert Lalonde, Catherine Strazielle, Guillaume Harlé, Stress, Immunité, Pathogènes (SIMPA), Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre de Recherches sur les Fonctionnements et Dysfonctionnements Psychologiques (CRFDP), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)
Subjects: Male, 0301 basic medicine, medicine.medical_specialty, Cerebellum, [SDV]Life Sciences [q-bio], Spatial Learning, Morris water navigation task, Biology, Placebo, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Corticosterone, Internal medicine, medicine, Animals, Maze Learning, Glucocorticoids, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Psychomotor learning, [SCCO.NEUR]Cognitive science/Neuroscience, General Neuroscience, General Medicine, Granule cell, Motor coordination, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, chemistry, 030217 neurology & neurosurgery, Hormone
Abstract: International audience; Glucocorticoids are involved in the developing brain but, in excessive amounts, may depress its growth and cause psychomotor development disorders. To test the long-term vulnerability of motor structures such as the cerebellum to supraphysiological corticosterone (CORT), the hormone was subcutaneously delivered at a dose of 20 mg/kg from postnatal day (P) 8 to P29 in C57BL/6 male mice evaluated for sensorimotor functions at P15, P22, P29, and 3 months. Relative to placebo, CORT increased motor activity in the open-field at P29 and 3 months as well as facilitating rotorod acquisition and visuomotor control necessary for swimming towards a visible goal without affecting spatial learning in the Morris water maze. CORT caused lobulespecific effects on cerebellar morphology by decreasing granule cell layer thickness in simplex lobule but increasing molecular and granule cell layer thickness in crus 2. The functional impact of these changes is indicated by significant correlations found between cerebellar size and activity levels or proficiency on the rotorod test of motor coordination.
Published: 2021
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15. Clinical Efficacy of Silodosin in Patients with Severe Lower Urinary Tract Symptoms Related to Benign Prostatic Obstruction: A Pooled Analysis of Phase 3 and 4 Trials

Author: Nicola Longo, Davide Arcaniolo, Francesco Montorsi, Enrico Finazzi Agrò, Massimiliano Creta, Vincenzo Mirone, Jean Nicolas Cornu, Marco De Sio, Ferdinando Fusco, Vittorio Imperatore, Claus G. Roehrborn, University of Naples Federico II = Università degli studi di Napoli Federico II, Service d'urologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), University of Texas Southwestern Medical Center [Dallas], Università degli Studi di Roma Tor Vergata [Roma], Histoire, Archéologie et Littératures des mondes chrétiens et musulmans médiévaux (CIHAM), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-École des hautes études en sciences sociales (EHESS)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Avignon Université (AU)-Centre National de la Recherche Scientifique (CNRS), IRCCS San Raffaele Scientific Institute [Milan, Italie], Urology Unit, Buon Consiglio Fatebenefratelli Hospital, Naples, Italy, Università degli studi della Campania 'Luigi Vanvitelli' = University of the Study of Campania Luigi Vanvitelli, Creta, Massimiliano, Cornu, Jean-Nicola, Roehrborn, Claus G, Finazzi Agrò, Enrico, Montorsi, Francesco, Longo, Nicola, Imperatore, Vittorio, De Sio, Marco, Arcaniolo, Davide, Mirone, Vincenzo, Fusco, Ferdinando, Università degli studi di Napoli Federico II, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, University of Rome 'Tor Vergeta', École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-École des hautes études en sciences sociales (EHESS)-Université Jean Moulin - Lyon 3 (UJML), and Università degli studi della Campania 'Luigi Vanvitelli'
Subjects: Male, medicine.medical_specialty, Indoles, Urology, 030232 urology & nephrology, Clinical Trials, Phase IV as Topic, Placebo, Benign prostatic obstruction, lower urinary tract symptoms, Silodosin, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 03 medical and health sciences, 0302 clinical medicine, Lower Urinary Tract Symptoms, Quality of life, Lower urinary tract symptoms, Prostate, Post-hoc analysis, medicine, Lower urinary tract symptom, Humans, In patient, Adrenergic alpha-Antagonists, ComputingMilieux_MISCELLANEOUS, Aged, business.industry, Middle Aged, medicine.disease, 3. Good health, Settore MED/24, Treatment Outcome, medicine.anatomical_structure, Clinical Trials, Phase III as Topic, 030220 oncology & carcinogenesis, Quality of Life, Urological Agents, International Prostate Symptom Score, business, medicine.drug
Abstract: We performed a post hoc analysis of data from phase 3 and 4 studies to evaluate the efficacy of silodosin 8mg in patients with severe lower urinary tract symptoms (LUTS) related to benign prostatic obstruction (BPO). The presence of two or more of the following criteria was adopted to define severity: total International Prostate Symptom Score (IPSS) 20-35, quality of life (QoL) score 5-6, maximum urinary flow
Published: 2021
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16. Risk of Postoperative Stenosis after Segmental Resection versus Disk Excision for Deep Endometriosis Infiltrating the Rectosigmoid: A Retrospective Study

Author: Jean Jacques Tuech, Antoine Scattarelli, Valérie Bridoux, Julien Coget, Sophia Braund, Clotilde Hennetier, Clemence Klapczynski, Horace Roman, Expert Center in the Diagnosis and Multidisciplinary Management of Endometriosis = Le Centre expert de diagnostic et de prise en charge multidisciplinaire de l’endométriose de Rouen, CHU Rouen, Normandie Université (NU), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Service de chirurgie digestive [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aarhus University Hospital, and Clinique Tivoli Ducos [Bordeaux]
Subjects: Adult, medicine.medical_specialty, Endometriosis, Rectum, Constriction, Pathologic, Stoma, Colonic Diseases, Postoperative complications, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Humans, Risk factor, Retrospective Studies, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics and Gynecology, Retrospective cohort study, Deep endometriosis, medicine.disease, Bowel stenosis, 3. Good health, Surgery, Stenosis, Rectal Diseases, medicine.anatomical_structure, Rectovaginal fistula, 030220 oncology & carcinogenesis, Female, Segmental resection, business
Abstract: International audience; Study objective: To assess the prevalence, risk factors, and management of bowel stenosis after surgery for deep infiltrating endometriosis of the rectosigmoid using either disk excision (DE) or segmental resection (SR).Design: Retrospective study using data from consecutive cases recorded in the North-West Inter Regional Female Cohort for Patients with Endometriosis database.Setting: University tertiary referral center.Patients: Four hundred thirty-one consecutive patients managed for rectosigmoid endometriosis were enrolled in our study.Interventions: Laparoscopic SR or DE.Measurements and main results: One hundred sixty-five patients underwent DE, and 266 patients underwent SR. Large nodules ≥3 cm in diameter were more frequent in the SR group (73.3% vs 66.1%), whereas nodules infiltrating the low rectum were 3 times more frequent in the DE group (35.9% vs 11.3%). The frequency of vaginal excision (67.9% vs 62%) and stoma (46.7% vs 44.4%) were comparable between the DE and SR groups. Twenty-three patients presented with postoperative colorectal stenosis after SR (8.6%) versus none after DE (p
Published: 2021
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17. Clinimetric evaluation of muscle function tests for individuals with cystic fibrosis: A systematic review

Author: Yann Combret, Clément Medrinal, Francis-Edouard Gravier, Guillaume Prieur, Pascal Roux, Bouchra Lamia, Tristan Bonnevie, Gregory Reychler, Groupe Hospitalier du Havre, Groupe de Recherche sur le Handicap Ventilatoire (GRHV), Institute for Research and Innovation in Biomedicine (IRIB), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-CHU Rouen, Normandie Université (NU), ADIR Association (ADIR), CHU Rouen, Service Anesthésie et soins intensifs [CHU Rouen], Normandie Université (NU)-Normandie Université (NU), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and CCSD, Accord Elsevier
Subjects: 0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Cystic Fibrosis, Web of science, [SDV]Life Sciences [q-bio], Quadriceps strength, Upper limb muscle, Cystic fibrosis, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Lower limb muscle, Physical medicine and rehabilitation, medicine, Humans, business.industry, Inspiratory muscle, Muscle endurance, medicine.disease, Respiratory Muscles, [SDV] Life Sciences [q-bio], 030104 developmental biology, 030228 respiratory system, Pediatrics, Perinatology and Child Health, business
Abstract: Accurate testing of muscle function is essential in individuals with cystic fibrosis (CF). A literature search was conducted in MEDLINE, CENTRAL, CINAHL, PEDro, ScienceDirect and Web of Science according to PRISMA and COSMIN guidelines from inception to September 2019 to investigate the clinimetric properties of muscle tests in individuals with CF. The search identified 37 studies (1310 individuals) and 34 different muscle tests. Maximal inspiratory pressure, inspiratory work capacity and quadriceps strength measured by computerised dynamometry were identified as reliable tests of muscle function. The one-minute sit-to-stand test was found to have high reliability but its validity to measure quadriceps strength is unknown. The clinimetric properties of other routinely used tests have not been reported in people with CF. Very different measurement procedures were identified. Inspiratory muscle and quadriceps testing can be considered as reliable but high-quality studies evaluating tests of other muscles function (e.g. muscle endurance) are lacking.
Published: 2020
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18. Expectations of IBS patients concerning disease and healthcare providers: Results of a prospective survey among members of a French patients’ association

Author: Guillaume Gourcerol, Jean-Marc Sabate, Thierry Piche, P. Ducrotté, Pauline Jouet, S. Bruley des Varannes, S. Façon, D. Denhez, Michel Dapoigny, Bruno Bonaz, F. Iglicki, F. Zerbib, François Mion, Hôpital Ambroise Paré [AP-HP], Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), CHU Bordeaux [Bordeaux], CHU Clermont-Ferrand, Institut des Maladies de l'Appareil Digestif, Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Grenoble, Hospices Civils de Lyon (HCL), Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de physiologie digestive, urinaire, respiratoire et de l'exercice [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, and Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN)
Subjects: Male, Quality of life, medicine.medical_specialty, Disease, Patients's organization, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Disease severity, Surveys and Questionnaires, Health care, Humans, Medicine, Patients expectations, Association (psychology), Prospective survey, Irritable bowel syndrome, Hepatology, business.industry, Gastroenterology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Middle Aged, medicine.disease, 3. Good health, 030220 oncology & carcinogenesis, Family medicine, Female, 030211 gastroenterology & hepatology, France, business, Healthcare providers
Abstract: International audience; Background and aimsIBS patients have an impaired quality of life (QoL) and feel dissatisfaction with medical care. We aim to describe the expectations of members of the French Association of IBS patients (APSSII) concerning health care providers (HCPs) and a patients’ organization.Patients and methodsFrom January to June 2013, APSSII members were asked to answer questionnaires on their expectations and experiences concerning IBS and HCP.Results222/330 (67%) responded (women: 68.5%, 46.5 ± 17.7 years, disease duration: 8.8 ± 0.7 years, IBS-D 33.6%, IBS-C 26.7%, IBS-M 38.2%. IBS-SSS > 300 in 53% and HAD score > 19 in 45%). QoL impairment was correlated with disease severity and HAD score (r = −0.707 and r = −0.484, P < 0.001 respectively), but not with IBS subtype. Expectations for IBS were “improved health”, “better information on causes and treatments” (94%) and “better disease recognition” (86%). A significant gap was observed between expectations and experiences with HCPs. Better information, less isolation, recognition of the disease and a decrease in medical expenses were the main expectations for joining a patients’ organization.ConclusionsFrench IBS patients have a severe disease with a significant psychological impact and impaired QoL in half of the patients, certain unsatisfied expectations concerning HCP and high expectations in joining a patients’ organization.
Published: 2020
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19. A Reappraisal of Outcome of Elective Surgery After Successful Non-Operative Management of an Intra-Abdominal Abscess Complicating Ileocolonic Crohn’s Disease: A Subgroup Analysis of a Nationwide Prospective Cohort

Author: R Souche, Eddy Cotte, Philippe Zerbib, Stéphane Benoist, Léon Maggiori, Jérôme Loriau, Adeline Germain, Guillaume Meurette, L Beyer-Berjot, Amine Rahili, Karine Pautrat, V Bridoux, Jean-Pierre Duffas, Yves Panis, Jérémie H. Lefevre, J. L. Faucheron, Eric Vicaut, Q Denost, M K Collard, Véronique Desfourneaux, Antoine Brouquet, H Corté, Christine Denet, Service de Chirurgie générale et digestive [CHU Le Kremlin-Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille], Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Saint-André [CHU de Bordeaux], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Lyon Sud, Service de Chirurgie Digestive, Hospices Civils de Lyon (HCL), CHU Marseille, Hopital Saint-Louis [AP-HP] (AP-HP), Centre Hospitalier Universitaire de Rennes (CHU Rennes), Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Toulouse [Toulouse], Service de Chirurgie d'Oncologie Digestive [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Institut Mutualiste de Montsouris (IMM), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de chirurgie digestive [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Universitaire [Grenoble] (CHU), Service de Chirurgie digestive [GH Paris Saint-Joseph], Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Montpellier, and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Subjects: Adult, Male, medicine.medical_specialty, Abdominal Abscess, ileocolonic resection, Adolescent, Matched-Pair Analysis, Preoperative care, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, intra-abdominal abscess, Recurrence, medicine, Humans, Elective surgery, 10. No inequality, Abscess, Prospective cohort study, Aged, Aged, 80 and over, Crohn's disease, Nutritional Support, business.industry, Gastroenterology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Intra-abdominal Abscess, General Medicine, Middle Aged, bacterial infections and mycoses, medicine.disease, Anti-Bacterial Agents, 3. Good health, Surgery, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Propensity score matching, Drainage, Female, 030211 gastroenterology & hepatology, France, ileocolonic Crohn’s disease, business
Abstract: Background and AimsFew prospective data exist on outcomes of surgery in Crohn’s disease [CD] complicated by an intra-abdominal abscess after resolution of this abscess by antibiotics optionally combined with drainage.MethodsFrom 2013 to 2015, all patients undergoing elective surgery for CD after successful non-operative management of an intra-abdominal abscess [Abscess-CD group] were selected from a nationwide multicentre prospective cohort. Resolution of the abscess had to be computed tomography/magnetic resonance-proven prior to surgery. Abscess-CD group patients were 1:1 matched to uncomplicated CD [Non-Penetrating-CD group] using a propensity score. Postoperative results and long-term outcomes were compared between the two groups.ResultsAmong 592 patients included in the registry, 63 [11%] fulfilled the inclusion criteria. The abscess measured 37 ± 20 mm and was primarily managed with antibiotics combined with drainage in 14 patients and nutritional support in 45 patients. At surgery, a residual fluid collection was found in 16 patients [25%]. Systemic steroids within 3 months before surgery [p = 0.013] and the absence of preoperative enteral support [p = 0.001] were identified as the two significant risk factors for the persistence of a fluid collection. After propensity score matching, there was no significant difference between the Abscess-CD and Non-Penetrating-CD groups in the rates of primary anastomosis [84% vs 90% respectively, p = 0.283], overall [28% vs 15% respectively, p = 0.077] and severe postoperative morbidity [7% vs 7% respectively, p = 1.000]. One-year recurrence rates for endoscopic recurrence were 41% in the Abscess-CD and 51% in the Non-Penetrating-CD group [p = 0.159].ConclusionsSurgery after successful non-operative management of intra-abdominal abscess complicating CD provides good early and long-term outcomes.
Published: 2020
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20. Long-term follow-up reveals a low persistence rate of abobotulinumtoxinA injections for idiopathic overactive bladder

Author: Jean-Nicolas Cornu, A. Aublé, Fanny Paret, Maximilien Baron, C. Pfister, Service d'urologie [Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service d'Urologie [Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and CCSD, Accord Elsevier
Subjects: Male, medicine.medical_specialty, Long term follow up, Urology, 030232 urology & nephrology, Urinary incontinence, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Persistence (computer science), 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Clinical endpoint, Humans, Botulinum Toxins, Type A, Survival rate, ComputingMilieux_MISCELLANEOUS, Retrospective Studies, Urinary Bladder, Overactive, business.industry, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 3. Good health, Discontinuation, Treatment Outcome, Tolerability, Overactive bladder, Female, medicine.symptom, business, Follow-Up Studies
Abstract: Summary Introduction Little is known about long-term efficacy and tolerance of intra-detrusor injections of abobotulinumtoxinA for management of idiopathic overactive bladder (OAB). We report long-term efficacy and compliance of abobotulinumtoxinA in patients treated for OAB. Methods All patients treated with abotulinumtoxinA for OAB in a tertiary reference centre between 2005 and 2012 were included in a retrospective analysis. Patients received 150, 250 or 500 U of abotulinumtoxinA as first injection. The primary endpoint was the discontinuation rate at 5 years. Other outcomes of interest were: rate of failure, reasons for discontinuation and subsequent treatment elected in those who did not persist with abobotulinumtoxinA. Results Fifty-nine patients (50 women and 9 men) were included. Forty-one patients (69.4%) received 250 U of abobotulinumtoxinA as first injection. Thirteen patients (22%) received 500 U and 5 (8.4%) received 150 U of BoNT-A. Median follow-up was 83.6 months [0.3–183.6]. Median number of injections per patient was 2 [1–15] and median reinjection interval was 10.7 [3–86.4] months. The estimated 5-year discontinuation-free survival rate was 23.4%. Fourteen patients (23.7%) experienced persistent improvement of symptoms and 12 patients (20.3%) stopped the injections because of tolerability issues. Main cause of discontinuation was primary failure, which occurred in 21 patients (35.5%). Conclusion Overall, 59.3% of patients were successfully treated with first abobotulinumtoxinA injection. Although the estimated 5-year discontinuation-free survival rate is low, abobotulinumtoxinA could be considered as an alternative off-labelled in patients not responders to onabotulinumtoxinA after failure of other conservative measures. Level of proof 3.
Published: 2020
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21. Extended anterolateral transiliac approach to the sacral plexus

Author: Antoine-Guy Hue, Mourad Ould-Slimane, Rémi Gauthé, A.C. Tobenas-Dujardin, Franck Dujardin, Fabrice Duparc, Jordane Mouton, Service d'orthopédie et de traumatologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), and Université de Rouen Normandie (UNIROUEN)
Subjects: Sacrum, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Lumbosacral Plexus, Lumbosacral trunk, Ilium, medicine.nerve, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Orthopedics and Sports Medicine, Ischiorectal Fossa, Sacroiliac joint, 030222 orthopedics, Plexus, business.industry, 030229 sport sciences, musculoskeletal system, Trunk, Sacral plexus, Surgery, Lumbosacral plexus, medicine.anatomical_structure, Buttocks, business
Abstract: The approach to the sciatic plexus and lateral part of the sacrum is difficult. A subperitoneal anterolateral approach can be extended by sectioning the iliac bone above the acetabulum and lowering it toward the external part of the iliac wing and buttock. This transiliac anterolateral approach exposes the lumbosacral trunk, first sacral foramina and sciatic plexus to the origin of the sciatic trunk. Exposure can be extended upward by subperitoneal lumbotomy, downward by opening the ischiorectal fossa, or outward by trochanterotomy. This approach was used 18 times by one of the authors (FHD) for resection of 13 malignant tumors and 5 plexus releases. Procedure time was 3-6hours, with 500-4,000ml blood loss. The approach systematically enabled surgical objectives to be met. There was 1 septic complication that healed after debridement.
Published: 2020
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22. Association Between Pulmonary Embolism and COVID‐19 in Emergency Department Patients Undergoing Computed Tomography Pulmonary Angiogram: The PEPCOV International Retrospective Study

Author: Anne Laure Feral-Pierssens, Judith Gorlicki, Pierre Géraud Claret, Ben Bloom, Mélanie Roussel, Florent Femy, A Penaloza, Alfons Aguirre, Fabien Brigant, Òscar Miró, Pierrick Le Borgne, Alessio Marra, Said Laribi, Yonathan Freund, Sébastien Beaune, Olivier Lucidarme, Emmanuel Montassier, Tahar Chouihed, Céline Occelli, Anthony Chauvin, Bárbara Lara Hernández, Jennifer Truchot, Barbara Pena, Prabakar Vaittinada Ayar, Sami Ellouze, Marine Cachanado, Nicolas Javaud, Tabassome Simon, Marie Drogrey, Service des Urgences [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Hospital Clínic de Barcelona [Catalonia, Spain], ASST Papa Giovanni XXIII [Bergamo, Italy], Université de Sherbrooke (UdeS), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Cliniques Universitaires Saint-Luc [Bruxelles], Université Catholique de Louvain = Catholic University of Louvain (UCL), Pontificia Universidad Católica de Chile (UC), Hôpital Ambroise Paré [AP-HP], Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), SAMU 93 [Bobigny], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Hôpital Beaujon, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de médecine d'urgence [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Universidad de Alicante, IMIM-Hospital del Mar, Generalitat de Catalunya, Hôpital Louis Mourier - AP-HP [Colombes], Hôpital Lariboisière-Fernand-Widal [APHP], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Urgences [CHU Nantes], Hôtel-Dieu de Nantes, Microbiotes, Hôtes, Antibiotiques et Résistances bactériennes (MiHAR) (MiHAR), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Pasteur [Nice] (CHU), Services des urgences [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service des Urgences [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Hopital Saint-Louis [AP-HP] (AP-HP), Les Hôpitaux Universitaires de Strasbourg (HUS), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Nanomédecine Régénérative (NanoRegMed), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Radiologie [CHU Pitié-Salpétrière], Barts Health NHS Trust [London, UK], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Gestionnaire, Hal Sorbonne Université, Service d'Accueil des Urgences [CHU Pitié-Salpêtrière] (SAU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, and Service d'Urgences Adultes [CHU Saint-Antoine]
Subjects: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Pulmonary angiogram, Tomografia, [SDV]Life Sciences [q-bio], Computed tomography, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Clinical endpoint, Pandèmia de COVID-19, 2020, Embòlia pulmonar, medicine.diagnostic_test, business.industry, 030208 emergency & critical care medicine, Retrospective cohort study, General Medicine, Emergency department, medicine.disease, 3. Good health, Pulmonary embolism, [SDV] Life Sciences [q-bio], Emergency Medicine, business
Abstract: International audience; Background: There have been reports of procoagulant activity in patients with COVID-19. Whether there is an association between pulmonary embolism (PE) and COVID-19 in the emergency department (ED) is unknown. The aim of this study was to assess whether COVID-19 is associated with PE in ED patients who underwent a computed tomographic pulmonary angiogram (CTPA).Methods: A retrospective study in 26 EDs from six countries. ED patients in whom a CTPA was performed for suspected PE during a 2-month period covering the pandemic peak. The primary endpoint was the occurrence of a PE on CTPA. COVID-19 was diagnosed in the ED either on CT or reverse transcriptase-polymerase chain reaction. A multivariable binary logistic regression was built to adjust with other variables known to be associated with PE. A sensitivity analysis was performed in patients included during the pandemic period.Results: A total of 3,358 patients were included, of whom 105 were excluded because COVID-19 status was unknown, leaving 3,253 for analysis. Among them, 974 (30%) were diagnosed with COVID-19. Mean (±SD) age was 61 (±19) years and 52% were women. A PE was diagnosed on CTPA in 500 patients (15%). The risk of PE was similar between COVID-19 patients and others (15% in both groups). In the multivariable binary logistic regression model, COVID-19 was not associated with higher risk of PE (adjusted odds ratio = 0.98, 95% confidence interval = 0.76 to 1.26). There was no association when limited to patients in the pandemic period.Conclusion: In ED patients who underwent CTPA for suspected PE, COVID-19 was not associated with an increased probability of PE diagnosis. These results were also valid when limited to the pandemic period. However, these results may not apply to patients with suspected COVID-19 in general.
Published: 2020
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23. Joint Position Paper of the Working Group of Pacing and Electrophysiology of the French Society of Cardiology (SFC) and the Société française d’imagerie cardiaque et vasculaire diagnostique et interventionnelle (SFICV) on magnetic resonance imaging in patients with cardiac electronic implantable devices

Author: Jacques Mansourati, Louis Boyer, A Jacquier, Didier Klug, Nicolas Sadoul, Olivier Piot, Philippe Maury, Laurent Fauchier, Lucie Cassagnes, Frédéric Anselme, Jérôme Taieb, F. Sacher, B. Dubourg, Michel Chauvin, Daniel Gras, Jean-Nicolas Dacher, Eloi Marijon, Hubert Cochet, Gabriel Laurent, Axel Bartoli, Estelle Gandjbakhch, Serge Boveda, François Pontana, Nouvelles Cibles Pharmacologiques de la Protection Endothéliale et de l'Insuffisance Cardiaque (EnVI), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [APHP], DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service de cardiologie [Strasbourg], CHU Strasbourg, Service de cardiologie [CHU Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Institut d’Electronique et des Systèmes (IES), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), service d'Imagerie, Centre Hospitalier Universitaire de Clermont-Ferrand, IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Adhésion et Inflammation (LAI), Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de cardiologie Pédiatrique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Département Cardiologie, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), Biospectroscopie Translationnelle - EA 7506 (BIOSPECT), Université de Reims Champagne-Ardenne (URCA), Récepteurs nucléaires, maladies cardiovasculaires et diabète (EGID), Université de Lille, Droit et Santé-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Bordeaux (UB), Service de Cardiologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Clinique Pasteur, Toulouse, France., Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Working Group of Pacing, Electrophysiology of the French Society of Cardiology, Société française d’imagerie cardiaque et vasculaire diagnostique et interventionnelle (SFICV)., CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École des Ponts ParisTech (ENPC)-École polytechnique (X)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, DACHER, Jean Nicolas, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Clermont-Ferrand, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Clermont Université-Centre National de la Recherche Scientifique (CNRS)-Université d'Auvergne - Clermont-Ferrand I (UdA), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)
Subjects: medicine.medical_specialty, Medical device, Cardiac pacing, artificial, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, In patient, Magnetic resonance imaging (MRI), Contraindication, Radiological and Ultrasound Technology, medicine.diagnostic_test, medical device, business.industry, Magnetic resonance imaging, General Medicine, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Pacemaker, 030220 oncology & carcinogenesis, Cardiology, Position paper, Safety, business, Defibrillators
Abstract: International audience; Magnetic resonance imaging (MRI) has become the reference imaging for the management of a large number of diseases. The number of MR examinations increases every year, simultaneously with the number of patients receiving a cardiac electronic implantable device (CEID). A CEID was considered an absolute contraindication for MRI for years. The progressive replacement of conventional pacemakers and defibrillators by MR-conditional CEIDs and recent data on the safety of MRI in patients with "MR-nonconditional" CEIDs have progressively increased the demand for MRI in patients with a CEID. However, some risks are associated with MRI in CEID carriers, even with "MR-conditional" devices because these devices are not "MR-safe". A specific programing of the device in "MR-mode" and monitoring patients during MRI remain mandatory for all patients with a CEID. A standardized patient workflow based on an institutional protocol should be established in each institution performing such examinations. This joint position paper of the Working Group of Pacing and Electrophysiology of the French Society of Cardiology and the Société française d'imagerie cardiaque et vasculaire diagnostique et interventionnelle (SFICV) describes the effect and risks associated with MRI in CEID carriers. We propose recommendations for patient workflow and monitoring and CEID programming in MR-conditional, "MR-conditional nonguaranteed" and MR-nonconditional devices.
Published: 2020
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24. Characterizing the metabolic perturbations induced by activity-based anorexia in the C57Bl/6 mouse using 1H NMR spectroscopy

Author: Pierre Déchelotte, Moïse Coëffier, Natasa Giallourou, L. Belmonte, S. Nobis, Jonathan R. Swann, Najate Achamrah, Jean-Luc do Rego, Alexis Goichon, J. Breton, A. Morin, Division of Computational and Systems Medicine, Imperial College London, London, SW7 2AZ, UK, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Division of Computational and Systems Medicine, Imperial College London, London, SW7 2AZ, UK., Service Commun d'Analyse Comportementale (SCAC), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de nutrition [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, and Normandie Université (NU)
Subjects: 0301 basic medicine, medicine.medical_specialty, Proteolysis, Microbial metabolism, 030209 endocrinology & metabolism, Anorexia, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, 030109 nutrition & dietetics, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, digestive, oral, and skin physiology, C57BL/6 Mouse, Phenotype, Pathophysiology, 3. Good health, Metabolic pathway, Endocrinology, Anorexia nervosa (differential diagnoses), medicine.symptom, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Summary Background & aims Anorexia nervosa (AN) is a severe psychological and potentially life-threatening eating disorder. The activity-based anorexia (ABA) mouse model is commonly used to investigate physiological abnormalities associated with this disorder. Characterizing the holistic biochemical alterations induced by anorexia is essential to understanding AN pathophysiology as well as to define biomarkers for prognosis. Methods To unravel the adaptive biochemical mechanisms occurring in this model in response to self-starvation, the urinary, plasma and fecal metabolic phenotypes of mice under different experimental conditions were compared. This included control mice with and without physical activity (CT and CTPA mice), a group with limited food access (LFA), and a group with both limited food access and physical activity (ABA). Using 1H nuclear magnetic resonance (NMR) spectroscopy, several biochemical perturbations were observed. Results Physical activity altered the abundance of 14 fecal metabolites, including those involved in gut microbial metabolism and proteolysis. Food restriction disrupted a wide range of metabolic pathways including gut microbial metabolism, proteolysis and fatty acid breakdown (24 urinary and 6 plasma metabolites). The combined impact of food restriction and physical activity resulted in the same pattern of metabolic disruption (24 urine, 6 plasma). Conclusions This work defined the metabolic signatures of ABA mice and provides novel insights into biological adaptations of mice in response to both food restriction and physical activity. These results should be further confirmed in AN patients.
Published: 2020
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25. Immunothérapies du cancer : quel impact sur les fonctions cognitives ?

Author: Florence Joly, Hélène Castel, Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme Cancer et Cognition, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Cancéropole Nord-Ouest-Ligue Nationale Contre le Cancer (LNCC), Sciences, EDP, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), and Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Ligue Nationale Contre le Cancer (LNCC)-Cancéropole Nord-Ouest
Subjects: Oncology, 0303 health sciences, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], MEDLINE, Cancer, Cognition, General Medicine, medicine.disease, General Biochemistry, Genetics and Molecular Biology, 3. Good health, [SDV] Life Sciences [q-bio], 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, medicine, business, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology
Abstract: International audience
Published: 2020
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26. Management of 35 critically ill hyperammonemic neonates: Role of early administration of metabolite scavengers and continuous hemodialysis

Author: Stéphane Marret, Anaïs Brassier, Clément Pontoizeau, Mehdi Oualha, Marion Grimaud, L. de Saint Blanquat, Fabrice Lesage, Jean-Baptiste Arnoux, L. Dupic, S. Renolleau, Soumeya Bekri, C. Joffre, P. de Lonlay, Lenaig Abily-Donval, Chris Ottolenghi, Service de pédiatrie néonatale et réanimation - neuropédiatrie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université de Paris (UP), Département de biochime métabolique [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), and Université Paris Cité (UPC)
Subjects: Male, Continuous Renal Replacement Therapy, Antimetabolites, Critical Illness, [SDV]Life Sciences [q-bio], Metabolite, medicine.medical_treatment, Hemodynamics, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Renal Dialysis, 030225 pediatrics, Humans, Hyperammonemia, Medicine, Retrospective Studies, Pediatric intensive care unit, business.industry, Critically ill, Infant, Newborn, Neurotoxicity, Retrospective cohort study, medicine.disease, Combined Modality Therapy, 3. Good health, Treatment Outcome, chemistry, Anesthesia, Pediatrics, Perinatology and Child Health, Female, Hemodialysis, business
Abstract: Neurological involvement is frequent in inherited metabolic disease of the intoxication type. Hyperammonemic coma related to these diseases may cause severe neurological sequelae. Early optimal treatment is mandatory combining metabolite scavengers (MS) and sometimes continuous veno-venous hemodialysis (CVVHD). We aimed to describe the therapeutic management of hyperammonemia in neonates upon diagnosis of their metabolic disease and to compare neonates managed with MS alone or with both MS and CVVHD. We conducted a retrospective study including all neonates admitted for initial hyperammonemia to the pediatric intensive care unit of a Reference Center of Inherited Metabolic Diseases, between 2001 and 2012. The study included 35 neonates. Before admission, MS were initiated for 11 neonates. At admission, the median ammonia levels were 391 μmol/L and were significantly lower in neonates who received MS before admission. At admission, ammonia levels were 644 μmol/L in dialyzed and 283 μmol/L in non-dialyzed neonates. The median time to reach a 50% decrease of the initial ammonia levels was significantly shorter in dialyzed neonates; however, the normalization of ammonia levels was similar between dialyzed and non-dialyzed neonates. Hemodynamic disorders were more frequent in dialyzed neonates. Conclusion MS represent an effective treatment for hyperammonemia and should be available in all pediatric units to avoid the need for CVVHD. Although CVVHD enhances the kinetics of toxic metabolite decrease, it is associated with adverse hemodynamic effects.
Published: 2020
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27. Detection of copy-number variations from NGS data using read depth information: a diagnostic performance evaluation

Author: Anne-Claire Richard, Anne Rovelet-Lecrux, Dominique Campion, Sophie Coutant, Kilan Le Guennec, Jean-François Deleuze, Gaëlle Bougeard, Mathieu Castelain, Nathalie Drouot, Pascal Chambon, Stéphanie Vasseur, Thierry Frebourg, Jacqueline Bou, François Lecoquierre, Anne Boland, Géraldine Joly-Helas, Kévin Cassinari, Gaël Nicolas, Stéphane Rousseau, Steeve Fourneaux, Gwendoline Lienard, Edwige Kasper, Myriam Vezain, Pascale Saugier-Veber, Isabelle Tournier, Nathalie Le Meur, Olivier Quenez, Françoise Charbonnier, Emilie Bouvignies, Virginie N'Guyen-Viet, Stéphanie Baert-Desurmont, Sandrine Manase, Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Service de génétique [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre Hospitalier du Rouvray, PORCHET, Nathalie, Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: DNA Copy Number Variations, Computer science, [SDV]Life Sciences [q-bio], Read depth, Computational biology, Sensitivity and Specificity, Article, Workflow, 03 medical and health sciences, 0302 clinical medicine, Gene panel, Exome Sequencing, Multiplex polymerase chain reaction, Genetics, Humans, Genetic Testing, Copy-number variation, Exome, Genetics (clinical), 030304 developmental biology, Comparative Genomic Hybridization, 0303 health sciences, High-Throughput Nucleotide Sequencing, Predictive value, [SDV] Life Sciences [q-bio], Multiplex Polymerase Chain Reaction, 030217 neurology & neurosurgery, Comparative genomic hybridization
Abstract: International audience; The detection of copy-number variations (CNVs) from NGS data is underexploited as chip-based or targeted techniques are still commonly used. We assessed the performances of a workflow centered on CANOES, a bioinformatics tool based on read depth information. We applied our workflow to gene panel (GP) and whole-exome sequencing (WES) data, and compared CNV calls to quantitative multiplex PCR of short fluorescent fragments (QMSPF) or array comparative genomic hybridization (aCGH) results. From GP data of 3776 samples, we reached an overall positive predictive value (PPV) of 87.8%. This dataset included a complete comprehensive QMPSF comparison of four genes (60 exons) on which we obtained 100% sensitivity and specificity. From WES data, we first compared 137 samples with aCGH and filtered comparable events (exonic CNVs encompassing enough aCGH probes) and obtained an 87.25% sensitivity. The overall PPV was 86.4% following the targeted confirmation of candidate CNVs from 1056 additional WES. In addition, our CANOES-centered workflow on WES data allowed the detection of CNVs with a resolution of single exons, allowing the detection of CNVs that were missed by aCGH. Overall, switching to an NGS-only approach should be cost-effective as it allows a reduction in overall costs together with likely stable diagnostic yields. Our bioinformatics pipeline is available at: https://gitlab.bioinfo-diag.fr/nc4gpm/canoes-centered-workflow.
Published: 2020
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28. What We Talk About When We Talk About Binge Drinking: Towards an Integrated Conceptualization and Evaluation

Author: Jessica Mange, Fabien Gierski, Ingrid Banovic, Hélène Beaunieux, Pierre Maurage, Mickaël Naassila, Séverine Lannoy, Delphine Grynberg, Université Catholique de Louvain = Catholic University of Louvain (UCL), Stanford University, Laboratoire de psychologie de Caen Normandie (LPCN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Centre de Recherches sur les Fonctionnements et Dysfonctionnements Psychologiques (CRFDP), Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre Hospitalier Universitaire de Reims (CHU Reims), Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP), Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), and Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS)
Subjects: Adult, Male, Adolescent, Concept Formation, [SDV]Life Sciences [q-bio], media_common.quotation_subject, 030508 substance abuse, Binge drinking, Poison control, Binge Drinking, Young Adult, [SCCO]Cognitive science, 03 medical and health sciences, 0302 clinical medicine, Alcohol intoxication, Injury prevention, medicine, Humans, media_common, Ethanol, Conceptualization, Alcohol Abstinence, Brain, Human factors and ergonomics, Cognition, General Medicine, Abstinence, medicine.disease, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SCCO.PSYC]Cognitive science/Psychology, Blood Alcohol Content, Female, 0305 other medical science, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract: Rationale Binge drinking (BD), characterized by recurring alternations between intense intoxication episodes and abstinence periods, is the most frequent alcohol consumption pattern in youth and is growing in prevalence among older adults. Many studies have underlined the specific harmful impact of this habit by showing impaired abilities in a wide range of cognitive functions among binge drinkers, as well as modifications of brain structure and function. Aims Several controversies and inconsistencies currently hamper the harmonious development of the field and the recognition of BD as a specific alcohol consumption pattern. The main concern is the absence of consensual BD conceptualization, leading to variability in experimental group selection and alcohol consumption evaluation. The present paper aims at overcoming this key issue through a two-step approach. Methods and conclusions First, a literature review allows proposing an integrated BD conceptualization, distinguishing it from other subclinical alcohol consumption patterns. Six specific characteristics of BD are identified, namely, (1) the presence of physiological symptoms related to BD episodes, (2) the presence of psychological symptoms related to BD episodes, (3) the ratio of BD episodes compared to all alcohol drinking occasions, (4) the frequency of BD episodes, (5) the consumption speed and (6) the alternation between BD episodes and soberness periods. Second, capitalizing on this conceptual clarification, we propose an evaluation protocol jointly measuring these six BD characteristics. Finally, several research perspectives are presented to refine the proposed conceptualization.
Published: 2020
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29. Practice of stereoelectroencephalography (sEEG) in drug-resistant epilepsy: Retrospective series with surgery and thermocoagulation outcomes

Author: Nathalie Chastan, Stéphane Derrey, F. Le Goff, J.-L. Méreaux, A. Lebas, V. Gilard, Nicolas Magne, Emmanuel Gerardin, David Maltête, Service de neurochirurgie [CHU Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Service de neurophysiologie [Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and Service de Radiologie [CHU Rouen]
Subjects: Male, Drug Resistant Epilepsy, medicine.medical_specialty, Adolescent, Vagus Nerve Stimulation, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Electroencephalography, Neurosurgical Procedures, Stereoelectroencephalography, Stereotaxic Techniques, Young Adult, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Hematoma, Seizures, Electrocoagulation, medicine, Humans, Epilepsy surgery, Age of Onset, Child, Retrospective Studies, Cerebral Cortex, medicine.diagnostic_test, business.industry, Palliative Care, medicine.disease, Epileptogenic zone, Electrodes, Implanted, Surgery, Treatment Outcome, Child, Preschool, 030220 oncology & carcinogenesis, Female, Neurology (clinical), Nervous System Diseases, business, 030217 neurology & neurosurgery, Vagus nerve stimulation
Abstract: Objective The aim of this study was to determine the success rate of sEEG in locating the epileptogenic zone (EZ) in patients with pharmaco-resistant epilepsy. Secondary objectives were to analyze sEEG-related morbidity and outcomes for post-sEEG thermocoagulation and cortical resection. Methods Data were collected on 49 sEEGs from 46 consecutive patients between 2010 and 2018. Following sEEG, either resective or palliative surgery with vagus nerve stimulation was performed. In 8 patients, EZ thermocoagulation was performed before EEG leads were withdrawn. Outcomes were collected based on the Engel and ILAE outcome scales. Results sEEG was contributive in 45 of 49 recordings, with a success rate of 92% in locating the EZ. Minor complications, such as transient neurologic deficit and electrode implantation failures, occurred in 6%. One major complication occurred, with death due to atypical late hematoma. Thermocoagulation was performed in 8 patients and stopped or significantly reduced seizure frequency in 7 (88%). Outcome of surgical resection (n = 33) was good, with 20 (61%) seizure-free patients and 32 (97%) with definite improvement. Conclusions Our findings suggest that sEEG is an effective technique for EZ location in patients with drug-resistant epilepsy. sEEG was contributive in up to 92% of patients, allowing thermocoagulation and/or surgical resection that resulted in seizure-freedom in two-thirds and seizure-reduction in one-third of cases. This study highlights the need for strict selection of implantation candidates, with strong initial hypothesis as to EZ location.
Published: 2020
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30. Recommandations jointes des comités de l’AFU (neuro-urologie, CUROPF, CTMH) pour l’urologie fonctionnelle durant la crise sanitaire liée au COVID-19

Author: X. Gamé, Grégoire Robert, Gilles Karsenty, F. Michel, Jean-Nicolas Cornu, Sarah Gaillet, Comité de neuro-urologie-CUROPF-CTMH de l'AFU, Véronique Phé, CCSD, Accord Elsevier, Assistance Publique - Hôpitaux de Marseille (APHM), Service d'urologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), service d'urologie [CHU Bordeaux], CHU Bordeaux [Bordeaux], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service d'Urologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CUROPF-CTMH de l'AFU, and CHU Toulouse [Toulouse]
Subjects: Gynecology, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Urology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030232 urology & nephrology, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Medicine, business, ComputingMilieux_MISCELLANEOUS
Abstract: Resume Objectif La prise en charge des patients d’urologie est bouleversee par l’epidemie de COVID-19. En urologie fonctionnelle, certaines situations cliniques sont a haut risque de complication en cas de retard de prise en charge et il existe une grande heterogeneite de delais souhaitables de reprogrammation en cas d’annulation. Une hierarchisation de la priorite accordee aux actes d’urologie fonctionnelle est donc necessaire pour adapter les prises en charge durant la crise COVID-19 et mieux organiser la reprise d’activite post-epidemie. Materiel et methode L’avis des comites scientifiques de l’AFU dans le domaine de l’urologie fonctionnelle (comite de neuro-urologie, CUROPF, CTMH) a ete sollicite et complete par une revue des recommandations sur le sujet urologie et COVID-19 diffusee sur les reseaux sociaux ou publies. Ces avis ont ete reunis pour etablir des recommandations temporaires visant a aider la reorganisation des pratiques durant l’epidemie et lors de la phase post-critique. Resultats La majorite des recommandations diffusees (litterature ou reseaux sociaux – Twitter, LinkedIn) concernent la cancerologie ou l’ensemble de l’urologie. Huit sur dix proposent une annulation en bloc de tous les actes d’urologie fonctionnelle sans distinction. Les 3 comites reunis identifient pourtant 3 situations ou des actes chirurgicaux/instrumentaux devraient etre maintenus durant l’epidemie de COVID-19 (niveau A de priorite) : 2e temps de test de neuromodulation en cours, injections vesicales de toxine botulique A pour neuro-vessie non equilibree, cystectomie-Bricker pour fistule urinaire dans une escarre perineale ou neuro-vessie non equilibree avec insuffisance renale recente et fistules vesico-enterales ou uro-osseuses. Des adaptations de prise en charge des autres pathologies sont proposees ainsi que l’application de 3 autres niveaux de priorite (B, C, D) afin d’aider a la reprogrammation lors de la reprise de l’activite post-crise COVID-19. Dans tous les cas, l’accompagnement du patient, en particulier, par teleconsultation est essentiel. Conclusion Les 3 comites d’urologie fonctionnelle de l’AFU reunis indiquent qu’il existe des situations en urologie fonctionnelle pour lesquelles la prise en charge ne peut etre retardee, pour les autres des adaptations sont proposees. Une hierarchisation des priorites de reprogrammation apparait necessaire pour limiter l’impact des delais sur la sante des patients et faciliter l’organisation de la reprise d’activite apres la fin du confinement total.
Published: 2020
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31. Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort

Author: Serge Hercberg, Robert Benamouzig, Guillaume Savoye, Pauline Vasseur, Mathilde Touvier, Jean-Pierre Hugot, Chantal Julia, Annaïg Lan, Emmanuelle Dugelay, Camille Buscail, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP Hôpital universitaire Robert-Debré [Paris], Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de Gastroentérologie et nutrition pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Ministere de la SanteSante publique France (SPF)Institut National de la Sante et de la Recherche Medicale (Inserm)Institut National de la Recherche Agronomique (INRA)Conservatoire National des Arts et Metiers (CNAM)Universite Paris 13
Subjects: Adult, Male, medicine.medical_specialty, Inflammatory bowel disease, Gastroenterology, Dietary zinc, Zinc intake, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, Risk Factors, Internal medicine, Humans, Medicine, Hepatology, business.industry, Incidence, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, medicine.disease, Ulcerative colitis, Diet Records, Confidence interval, 3. Good health, Zinc, 030220 oncology & carcinogenesis, Relative risk, Dietary Supplements, Cohort, Colitis, Ulcerative, Female, 030211 gastroenterology & hepatology, France, business
Abstract: International audience; Introduction: This study aimed to assess the association between incident Crohn's disease (CD) or incident ulcerative colitis (UC) and dietary zinc intake.Methods: NutriNet-Santé cohort's participants who completed at least three 24-hour dietary records were included and incident CD or UC cases were identified. Multivariable Poisson models were performed to assess associations between tertiles of zinc intake and CD or UC.Results: Among the 105,832 participants, 27 reported incident CD and 48 reported incident UC. The relative risks of CD decreased with dietary zinc intakes. Compared with participants with the lowest tertile of zinc intake, the relative risks for CD were 0.60 (95% confidence interval [0.22-1.66]) and 0.12 (95% confidence interval [0.02-0.73]) for the second and the highest tertiles, respectively (Ptrend = 0.02). No significant association was observed for UC.Discussion: Dietary zinc intake was inversely associated with incident CD.
Published: 2020
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32. CT and MR imaging prior to transcatheter aortic valve implantation

Author: Marco Francone, Luigi Natale, Matthias Gutberlet, Jens Bremerich, Ricardo P.J. Budde, Alban Redheuil, Gianluca Pontone, Christian Loewe, Rodrigo Salgado, Kostantin Nikolaou, Florian Wolf, Jean-Nicolas Dacher, Rozemarijn Vliegenthart, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Basel (Unibas), Service d'imagerie médicale [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Université de Rouen Normandie (UNIROUEN), CHU Rouen, Medizinische Universität Wien = Medical University of Vienna, Catholic University of Rome, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Chirurgie cardiaque et thoracique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Groningen [Groningen], Universität Leipzig [Leipzig], Antwerp University Hospital [Edegem] (UZA), Radiology & Nuclear Medicine, Gestionnaire, Hal Sorbonne Université, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), and Cardiovascular Centre (CVC)
Subjects: [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, Heart Valve Diseases, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, VALVULAR HEART-DISEASE, 030204 cardiovascular system & hematology, Aortic valve stenosis, 030218 nuclear medicine & medical imaging, CORONARY OBSTRUCTION, 0302 clinical medicine, Bicuspid Aortic Valve Disease, ELDERLY-PATIENTS, Neuroradiology, medicine.diagnostic_test, valvular heart disease, Calcinosis, Interventional radiology, General Medicine, 3. Good health, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, REPLACEMENT, Aortic Valve, POTENTIAL ROLE, MULTIDETECTOR COMPUTED-TOMOGRAPHY, Radiology, Cardiac, medicine.medical_specialty, Consensus, Transcatheter aortic, Magnetic Resonance Imaging, Cine, Mistake, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, AMERICAN-COLLEGE, STENOSIS, Magnetic resonance imaging, Multidetector computed tomography, Transcatheter aortic valve replacement, 03 medical and health sciences, Imaging, Three-Dimensional, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Preoperative Care, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, MANAGEMENT, Humans, Radiology, Nuclear Medicine and imaging, Computer. Automation, business.industry, Correction, medicine.disease, Stenosis, Quality of Life, business, Tomography, X-Ray Computed, TASK-FORCE
Abstract: Transcatheter aortic valve replacement (TAVR) is a minimally invasive alternative to conventional aortic valve replacement in symptomatic patients with severe aortic stenosis and contraindications to surgery. The procedure has shown to improve patient’s quality of life and prolong short- and mid-term survival in high-risk individuals, becoming a widely accepted therapeutic option which has been integrated into current clinical guidelines for the management of valvular heart disease. Nevertheless, not every patient at high-risk for surgery is a good candidate for TAVR. Besides clinical selection, which is usually established by the Heart Team, certain technical and anatomic criteria must be met as, unlike in surgical valve replacement, annular sizing is not performed under direct surgical evaluation but on the basis of non-invasive imaging findings. Present consensus document was outlined by a working group of researchers from the European Society of Cardiovascular Radiology (ESCR) and aims to provide guidance on the utilisation of CT and MR imaging prior to TAVR. Particular relevance is given to the technical requirements and standardisation of the scanning protocols which have to be tailored to the remarkable variability of the scanners currently utilised in clinical practice; recommendations regarding all required pre-procedural measurements and medical reporting standardisation have been also outlined, in order to ensure quality and consistency of reported data and terminology. Key Points • To provide a reference document for CT and MR acquisition techniques, taking into account the significant technological variation of available scanners. • To review all relevant measurements that are required and define a step-by-step guided approach for the measurements of different structures implicated in the procedure. • To propose a CT/MR reporting template to assist in consistent communication between various sites and specialists involved in the procedural planning. Electronic supplementary material The online version of this article (10.1007/s00330-019-06357-8) contains supplementary material, which is available to authorized users.
Published: 2020
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33. Current results of left ventricular assist device therapy in France: the ASSIST-ICD registry

Author: Hoang Minh Tam, Marylou Para, Olivier Chavanon, Clément Delmas, Marie Cecile Bories, Constance Verdonk, Vlad Gariboldi, Magali Michel, Fabrice Colas, Marie Bielefeld, Amedeo Anselmi, Martin Kloeckner, Jean-Philippe Verhoye, Thierry Bourguignon, André Vincentelli, Stéphane Boulé, Fabrice Vanhuyse, Michel Kindo, Julien Guihaire, Camille Dambrin, Annette Belin, Costin Radu, Nicolas D'Ostrevy, Hugues Blangy, Jérôme Jouan, Jean-François Obadia, Pierre-Yves Litzler, Vincent Galand, Gerard Babatasi, Edeline Pelcé, Laurent Barandon, Mathieu Pernot, Benjamin Duband, Philippe Rouvière, Philippe Gaudard, Nicolas Lellouche, Thomas Senage, Erwan Flecher, Aude Boignard, Fabien Garnier, Raphaël P. Martins, Matteo Pozzi, Frédéric Anselme, Thibaud Genet, CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Coeur Poumon [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Les Hôpitaux Universitaires de Strasbourg (HUS), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de chirurgie thoracique et cardio-vasculaire, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Université de Montpellier (UM), Université de Montpellier (UM), Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Michallon, Clinique de chirurgie cardiaque, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Service de cardiologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hôpital Charles Nicolle [Rouen], Service de chirurgie cadiovasculaire et thoracique [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Université Paris-Sud - Paris 11 (UP11), Hôpital Henri Mondor, CHU Henri Mondor, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), CHU Clermont-Ferrand, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de chirurgie thoracique cardiaque et vasculaire [Rennes] = Thoracic and Cardiovascular Surgery [Rennes], Fédération Française de Cardiologie, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-Normandie Université (NU), CHU Henri Mondor [Créteil], and MORNET, Dominique
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, medicine.medical_treatment, Temporal trends, Outcomes, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, medicine, Clinical endpoint, Humans, Cumulative incidence, Registries, Retrospective Studies, Heart Failure, business.industry, Cardiogenic shock, General Medicine, equipment and supplies, medicine.disease, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Surgery, Transplantation, Treatment Outcome, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Ventricular assist device, Life support, Left ventricular assist devices, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Heart-Assist Devices, Implant, Cardiology and Cardiovascular Medicine, business, Destination therapy
Abstract: OBJECTIVES Our goal was to provide a picture of left ventricular assist device (LVAD) activity in France between 2007 and 2016 based on the multicentric ASSIST-ICD registry. METHODS We retrospectively collected 136 variables including in-hospital data, follow-up survival rates and adverse events from 671 LVAD recipients at 20 out of 24 LVAD implant centres in France. The average follow-up time was 1.2 years (standard deviation: 1.4); the total follow-up time was 807.5 patient-years. RESULTS The included devices were the HeartMate II®, HeartWare LVAS® or Jarvik 2000®. The overall likelihood of being alive while on LVAD support or having a transplant (primary end point) at 1, 2, 3 and 5 years postimplantation was 65.2%, 59.7%, 55.9% and 47.7%, respectively, given a cumulative incidence of 29.2% of receiving a transplant at year 5. At implantation, 21.5% of patients were on extracorporeal life support. The overall rate of cardiogenic shock at implantation was 53%. The major complications were driveline infection (26.1%), pump pocket or cannula infection (12.6%), LVAD thrombosis (12.2%), ischaemic (12.8%) or haemorrhagic stroke (5.4%; all strokes 18.2%), non-cerebral haemorrhage (9.1%) and LVAD exchange (5.2%). The primary end point (survival) was stratified by age at surgery and by the type of device used, with inference from baseline profiles. The primary end point combined with an absence of complications (secondary end point) was also stratified by device type. CONCLUSIONS The ASSIST-ICD registry provides a real-life picture of LVAD use in 20 of the 24 implant centres in France. Despite older average age and a higher proportion of patients chosen for destination therapy, survival rates improved compared to those in previous national registry results. This LVAD registry contrasts with other international registries because patients with implants have more severe disease, and the national policy for graft attribution is distinct. We recommend referring patients for LVAD earlier and suggest a discussion of the optimal timing of a transplant for bridged patients (more dismal results after the second year of support?).
Published: 2020
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34. Fructose and irritable bowel syndrome

Author: Moïse Coëffier, Guillaume Gourcerol, Veronique Douard, Chloé Melchior, Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de nutrition [CHU Rouen], Service de physiologie digestive, urinaire, respiratoire et de l'exercice [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, and Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN)
Subjects: Male, 0301 basic medicine, Osmosis, Dietary Sugars, knockout, Medicine (miscellaneous), Fructose malabsorption, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Irritable bowel syndrome, education.field_of_study, Nutrition and Dietetics, medicine.diagnostic_test, Pathophysiology, 3. Good health, Intestines, Fructose intake, Breath Tests, Female, 030211 gastroenterology & hepatology, Low-fructose diet, medicine.medical_specialty, Population, Fructose, 03 medical and health sciences, ketohexokinase, Malabsorption Syndromes, Internal medicine, Hypersensitivity, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Humans, education, irritable bowel syndrome, Breath test, business.industry, High-fructose corn syrup, carbohydrate responsive element-binding protein, fermentable oligo, medicine.disease, gastrointestinal, Chronic disorders, Diet, 030104 developmental biology, high-fructose corn syrup, chemistry, Fermentation, di-mono-saccharides and polyols, business
Abstract: Irritable bowel syndrome (IBS) is a chronic disorder characterised by recurrent abdominal pain or discomfort and transit disturbances with heterogeneous pathophysiological mechanisms. The link between food and gastrointestinal (GI) symptoms is often reported by patients with IBS and the role of fructose has recently been highlighted. Fructose malabsorption can easily be assessed by hydrogen and/or methane breath test in response to 25 g fructose; and its prevalence is about 22 % in patients with IBS. The mechanism of fructose-related symptoms is incompletely understood. Osmotic load, fermentation and visceral hypersensitivity are likely to participate in GI symptoms in the IBS population and may be triggered or worsened by fructose. A low-fructose diet could be integrated in the overall treatment strategy, but its role and implication in the improvement of IBS symptoms should be evaluated. In the present review, we discuss fructose malabsorption in adult patients with IBS and the interest of a low-fructose diet in order to underline the important role of fructose in IBS.
Published: 2020
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35. France’s 2018 Report Card on Physical Activity for Children and Youth: Results and International Comparisons

Author: Salomé Aubert, Julien Aucouturier, David Thivel, Benjamin Larras, Julien Schipman, Corinne Praznoczy, Alicia Fillon, Caroline Ganière, Martine Duclos, Jeremy Vanhelst, Pauline Genin, Children's hospital of Eastern Ontario Research Institute [Ottawa, canada] (CHEO), University of Lille, Université d'Artois (UA), Université du Littoral Côte d'Opale (ULCO), Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université de Lille-Université du Littoral Côte d'Opale (ULCO), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire de Physiologie et Biologie du Sport, Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Centre d’études des transformations des activités physiques et sportives (CETAPS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Institut national du sport, de l'expertise et de la performance (INSEP), Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Clermont-Ferrand, Matmut insurance company, and Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille
Subjects: Cross-Cultural Comparison, Male, Adolescent, Applied psychology, Physical fitness, Physical activity, Health Promotion, History, 21st Century, 03 medical and health sciences, 0302 clinical medicine, Humans, active transportation, Orthopedics and Sports Medicine, adolescents, 030212 general & internal medicine, Child, Grading (education), Exercise, Built environment, Active play, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Government, business.industry, Health Policy, 4. Education, International comparisons, 030229 sport sciences, sedentary behaviors, Evaluation Studies as Topic, Child, Preschool, Female, France, physical activity promotion, Psychology, business, Report card
Abstract: Background: Insufficient levels of physical activity and increasing sedentary time among children and youth are being observed internationally. The purpose of this paper is to summarize findings from France’s 2018 Report Card on physical activity for children and youth, and to make comparisons with its 2016 predecessor and with the Report Cards of other countries engaged in the Global Matrix 3.0. Methods: The France’s 2018 Report Card was developed following the standardized methodology established for the Global Matrix 3.0 by grading 10 common physical activity indicators using best available data. Grades were informed by national surveys, peer-reviewed literature, government and nongovernment reports, and online information. Results: The expert panel awarded the following grades: overall physical activity, D; organized sport participation and physical activity, C−; active play, INC; active transportation, C−; sedentary behaviors, D−; physical fitness, B–; family and peers, INC; school, B; community and the built environment, INC; and government, C. Conclusions: Very concerning levels of physical activity and sedentary behaviors among French children and youth were observed, highlighting the urgent need for well-designed national actions addressing the presented physical inactivity crisis. The top 3 strategies that should be implemented in priority to improve the lifestyle of French children and youth are provided.
Published: 2020
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36. Targeted genotyping of circulating tumor DNA for classical Hodgkin lymphoma monitoring: a prospective study

Author: J. Lequesne, Marie Cornic, Stéphane Leprêtre, Lucile Bessi, Elena-Liana Veresezan, Elodie Bohers, Justine Loret, Anne-Lise Menard, Hervé Tilly, Nathalie Contentin, Pierre-Julien Viailly, Aspasia Stamatoullas, Vincent Camus, Stéphanie Becker, Jean-Michel Picquenot, Hélène Lanic, Pierre Decazes, Sydney Dubois, Pascaline Etancelin, Pascal Lenain, Mathieu Viennot, Bénédicte Marcq, Fabrice Jardin, Emilie Lemasle, Lucie Burel, Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Service de médecine nucléaire [Rouen], and CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel)
Subjects: Adult, Oncology, medicine.medical_specialty, Genotype, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Vinblastine, Article, Circulating Tumor DNA, Bleomycin, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Medicine, Hodgkin's Lymphoma, Prospective Studies, Liquid biopsy, Prospective cohort study, Genotyping, Aged, Retrospective Studies, Aged, 80 and over, Minimal Residual Disease, Chemotherapy, Cytogenetics and Molecular Genetics, business.industry, Editorials, Retrospective cohort study, Hematology, Middle Aged, Hodgkin's lymphoma, medicine.disease, Hodgkin Disease, Minimal residual disease, 3. Good health, Dacarbazine, ABVD, Doxorubicin, 030220 oncology & carcinogenesis, Mutation, business, 030215 immunology, medicine.drug
Abstract: The relevance of circulating tumor DNA (ctDNA) analysis as a liquid biopsy and minimal residual disease tool in the management of classical Hodgkin lymphoma (cHL) patients was demonstrated in retrospective settings and remains to be confirmed in a prospective setting. We developed a targeted Next-Generation sequencing (NGS) panel for fast analysis (AmpliSeq® technology) of nine commonly mutated genes in biopies and ctDNA of cHL patients. We then conducted a prospective trial to assess ctDNA follow-up at diagnosis and after two cycles (C2) of chemotherapy. Sixty cHL patients treated by first line conventional chemotherapy (BEACOPPescalated [21.3%], ABVD/ABVD-like [73.5%] and other regimens [5.2%, for elderly patients]) were assessed in this noninterventional study. The median age of the patients was 33.5 years (range: 20-86). Variants were identified in 42 (70%) patients. Mutations of NFKBIE, TNFAIP3, STAT6, PTPN1, B2M, XPO1, ITPKB, GNA13 and SOCS1 were found in 13.3%, 31.7%, 23.3%, 5%, 33.3%, 10%, 23.3%, 13.3% and 50% of patients, respectively. ctDNA concentration and genotype were correlated with clinical characteristics and presentation. Regarding early therapeutic response, 45 patients (83%, not available [NA] =6) had a negative positron emission tomography (PET) after C2 (Deauville Score 1-3). The mean of DeltaSUVmax after C2 was -78.8%. ctDNA after C2 was analysed in 54 patients (90%). ctDNA became rapidly undetectable in all cases after C2. Variant detection in ctDNA is suitable to depict the genetic features of cHL at diagnosis and may help to assess early treatment response, in association with PET. Clinical Trial reference: NCT02815137.
Published: 2020
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37. Repeating a suicide attempt during adolescence: risk and protective factors 12 months after hospitalization

Author: Hugues Pellerin, Priscille Gerardin, Jean-Marc Guilé, David Cohen, Bojan Mirkovic, Sébastien Garny de la Rivière, Angèle Consoli, Laboratoire de recherches cliniques et en santé publique sur les handicaps psychique, cognitif et moteur (HANDIReSP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), CHU Rouen, Normandie Université (NU), Institut des Systèmes Intelligents et de Robotique (ISIR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Amiens-Picardie, Centre de Recherches sur les Fonctionnements et Dysfonctionnements Psychologiques (CRFDP), Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Pfizer Foundation Fondation de France, and We would like to acknowledge Rouen University Hospital, Rouvray Hospital, Pfizer Foundation, Fondation de France, and the Commission Permanente de Coopération Franco-Québécoise for supporting this project. We would also like to thank the research collaborators and all interviewees for their unique contribution to the study.
Subjects: Coping (psychology), medicine.medical_specialty, Adolescent, media_common.quotation_subject, Protective factor, Poison control, Suicide prevention, 03 medical and health sciences, 0302 clinical medicine, Suicide attempt, Developmental and Educational Psychology, Child and adolescent psychiatry, Medicine, 0501 psychology and cognitive sciences, Psychiatry, media_common, business.industry, 05 social sciences, General Medicine, 030227 psychiatry, 3. Good health, Psychiatry and Mental health, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Suicidal behaviour, Pediatrics, Perinatology and Child Health, Temperament, Coping, Cohort study, business, 050104 developmental & child psychology
Abstract: International audience; Suicide attempts (SAs) are a public health concern in adolescence. A brief hospitalization is recommended, but access to inpatient wards is often not available. In addition, numerous risk factors for SA recurrence have been identified, but few studies have explored protective factors. Here, we aimed to assess the role of both risk and protective factors on SA relapse in a context of free access to inpatient services. We performed a prospective follow-up study of 320 adolescents who were hospitalized for an SA between January 2011 and December 2014 in France. Assessments at baseline included socio-demographics, clinical characteristics, temperament, reasons for living, spirituality, and coping. Patients were re-evaluated at 6 months and 12 months for depression severity and SA relapse. A total of 135 and 91 patients (78 girls, 12 boys, aged 13–17) were followed up at 6 and 12 months, respectively. At the 12-month follow-up, 28 (30%) subjects had repeated an SA. Adolescents who either had a history of SA or were receiving psychotropic treatment at baseline were at higher risk of recurrence. Several variables had a protective effect: (1) productive coping skills, namely, working hard and achieving, physical recreation, and seeking relaxing diversions; (2) a particular temperament trait, namely, cooperativeness; and (3) having experienced more life events. We also found a significant interaction: the higher the depression score during follow-up, the lower the protective effect of productive coping. Our findings confirm that a history of SA and seeking psychiatric care with medication are risk factors for SA relapse. However, productive coping strategies and cooperativeness are protective factors, and the improvement of such strategies as well as treatment of persisting depression should be a goal of psychotherapy treatment offered to suicidal adolescents.
Published: 2020
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38. Artérite gigantocellulaire : apport de l’écho-doppler

Author: B. Membrey, G. Armengol, Sébastien Miranda, Ygal Benhamou, Hervé Levesque, Nicole Cailleux, Service de Médecine Interne [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and CCSD, Accord Elsevier
Subjects: 030203 arthritis & rheumatology, EchoDoppler, business.industry, [SDV]Life Sciences [q-bio], Gastroenterology, [SDV] Life Sciences [q-bio], 03 medical and health sciences, Artérite à cellules géantes, 0302 clinical medicine, Color-duplex ultrasound, Horton, Diagnosis, Color duplex ultrasound, Internal Medicine, Medicine, Diagnostic, 030212 general & internal medicine, business, Nuclear medicine, Giant cell arteritis
Abstract: Giant cell arteritis is the most common primary vasculitis of large-vessel occurring in subjects over 50 years of age. Many imaging techniques has been evaluated to improve the diagnosis of giant cell arteritis. Among these imaging techniques, ultrasound has shown good performances to detect inflammatory involvement of the temporal arteries as well as branches of the aorta. Several publications and recent EULAR recommendations have emhasized the place of this tool in the diagnosis of giant cell arteritis., L’artérite à cellules géantes est la plus fréquente des vascularites primitives des artères de gros calibre survenant chez les sujets de plus de 50 ans. Plusieurs examens d’imagerie ont été évalués dans le but d’affiner le diagnostic de l’artérite à cellules géantes. Parmi ces techniques, l’écho-doppler a montré de bonnes performances pour dépister une atteinte inflammatoire des artères temporales ainsi que des branches de l’aorte. Plusieurs publications et les récentes recommandations de l’EULAR ont réaffirmé la place de cette technique dans le diagnostic d’artérite à cellules géantes.
Published: 2020
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39. Faim postopératoire après une chirurgie ambulatoire chez les patientes anesthésiés à l’aide de propofol vs sévoflurane: une étude randomisée contrôlée

Author: André Gillibert, Nathalie Rives, Emmanuel Besnier, Thomas Clavier, Bertrand Dureuil, Benoit Berby, Jean Selim, Vincent Compère, Antoine Ghemired, Anne Perdrix, Benoit Froëmer, UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Génétique du cancer et des maladies neuropsychiatriques (GMFC), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de biostatistiques [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de soins intensifs [CHU Rouen], Gamétogenèse et Qualité du Gamète - ULR 4308 (GQG), Normandie Université (NU)-Normandie Université (NU)-Université de Lille, Service de réanimation médicale [CHU Rouen], Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Différenciation et communication neuronale et neuroendocrine (DC2N), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Hôpital Charles Nicolle [Rouen]-CHU Rouen, and Department of Anesthesiology and Critical Care, Rouen University Hospital, Rouen, France
Subjects: Hunger, Visual analogue scale, [SDV]Life Sciences [q-bio], Outpatient surgery, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Sevoflurane, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, Interquartile range, medicine, Clinical endpoint, Humans, Postoperative Period, Propofol, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Transvaginal oocyte retrieval, business.industry, General Medicine, 3. Good health, Anesthesiology and Pain Medicine, Ambulatory Surgical Procedures, Anesthesia, Anesthesia Recovery Period, Anesthetics, Inhalation, Anesthesia, Intravenous, Anesthesia, Inhalation, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Anesthetics, Intravenous, medicine.drug
Abstract: Previous preclinical and preliminary clinical data suggest an appetite-stimulating effect of propofol compared with halogenated drugs. This study compared the effects of propofol with those of sevoflurane on recovery of hunger during the postoperative period.Patients undergoing outpatient transvaginal oocyte retrieval were randomized to propofol-remifentanil (propofol group) or sevoflurane-remifentanil (sevoflurane group) anesthesia. The primary endpoint was the time before feeling hungry (≥ 50/100 mm on a visual analogue scale). Secondary endpoints included plasma levels of ghrelin, leptin, and insulin (ten minutes, one hour, and two hours after anesthesia), caloric intake at first feed, and discharge readiness time.In the 58 patients allocated to either the propofol or sevoflurane group, there was no difference in the median [interquartile range] recovery time of hunger (97 [75-138] vs 97 [80-140] min, respectively; median difference, 1; 95% confidence interval [CI], - 15 to 14; P = 0.91); caloric intake (245 [200-343] vs 260 [171-314] kcal; P = 0.39); or discharge readiness time (125 [85-153] vs 125 [95-174] min, P = 0.29). The groups showed no difference in crude plasma levels of ghrelin, leptin, and insulin at any time-point. When peptide plasma levels were expressed as a % change from baseline, there was a higher insulin plasma level one hour after anesthesia in the sevoflurane group (median difference, 4.9%; 95% CI, - 16.2 to 43.4) compared with the propofol group (median difference, - 21.2%; 95% CI, - 35.7 to 9.1; adjusted P = 0.01).Propofol did not accelerate the recovery of hunger compared with sevoflurane after outpatient minor surgery. Moreover, propofol did not have distinguishable effects on other clinical or biological parameters associated with food intake.www.ClinicalTrials.gov (NCT02272166); registered 22 October, 2014.RéSUMé: OBJECTIF: Des données précliniques et cliniques préliminaires suggèrent un effet de stimulation de l’appétit du propofol par rapport aux gaz halogénés. Cette étude a comparé les effets du propofol à ceux du sévoflurane sur le rétablissement de la faim en période postopératoire. MéTHODE: Des patientes subissant un prélèvement des ovocytes par voie transvaginale ont été randomisées à recevoir une anesthésie à base de propofol et rémifentanil (groupe propofol) ou de sévoflurane et rémifentanil (groupe sévoflurane). Le critère d’évaluation principal était la période de temps avant de ressentir de la faim (≥ 50/100 mm sur une échelle visuelle analogique). Les critères d’évaluation secondaires comprenaient les taux plasmatiques de ghréline, de leptine et d’insuline (à dix minutes, une heure et deux heures après l’anesthésie), l’apport calorique lors du premier repas, et le moment où les patientes étaient prêtes à recevoir leur congé. RéSULTATS: Chez les 58 patientes allouées aux groupes propofol ou sévoflurane, aucune différence n’a été observée dans le temps médian [écart interquartile (ÉIQ)] jusqu’à retour de la faim (97 [75–138] vs 97 [80–140] min, respectivement; différence médiane, 1; intervalle de confiance [IC] 95 %, − 15 à 14; P = 0,91), ni dans l’apport calorique (245 [200–343] vs 260 [171–314] kcal; P = 0,39) ou le moment où elles étaient prêtes à recevoir leur congé (125 [85-153] vs 125 [95-174] min, P = 0,29). Les groupes n’ont démontré aucune différence en matière de taux plasmatiques de ghréline, de leptine et d’insuline à quelque point dans le temps que ce soit. Lorsque les taux plasmatiques de peptides étaient exprimés en % de changement par rapport aux taux de base, on a observé un taux plasmatique plus élevé d’insuline une heure après l’anesthésie dans le groupe sévoflurane (différence médiane, 4,9 %; IC 95 %, − 16,2 à 43,4) par rapport au groupe propofol (différence médiane, − 21,2 %, IC 95 %, − 35,7 à 9,1; P ajusté = 0,01). CONCLUSION: Le propofol n’a pas accéléré le retour de la faim par rapport au sévoflurane après une chirurgie ambulatoire mineure. De plus, le propofol n’a pas démontré d’effets distinctifs sur d’autres paramètres cliniques ou biologiques associés à l’ingestion de nourriture. ENREGISTREMENT DE L’éTUDE: www.ClinicalTrials.gov (NCT02272166); enregistrée le 22 octobre 2014.
Published: 2020
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40. UMI-Gen: A UMI-based read simulator for variant calling evaluation in paired-end sequencing NGS libraries

Author: Caroline Bérard, Thierry Lecroq, Fabrice Jardin, Vincent Sater, Pierre-Julien Viailly, Philippe Ruminy, Élise Prieur-Gaston, Equipe Traitement de l'information en Biologie Santé (TIBS - LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CCSD, Accord Elsevier, Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)
Subjects: Computer science, lcsh:Biotechnology, Biophysics, Word error rate, Biochemistry, DNA sequencing, chemistry.chemical_compound, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, lcsh:TP248.13-248.65, Variant calling, Genetics, Nucleotide, Copy-number variation, MIT License, ComputingMilieux_MISCELLANEOUS, Paired-end tag, Simulation, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM], 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Biological data, Sequence analysis, UMI, Pipeline (software), Computer Science Applications, Identifier, chemistry, NGS, 030220 oncology & carcinogenesis, Simulator, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], DNA, Research Article, Biotechnology
Abstract: MotivationWith Next Generation Sequencing becoming more affordable every year, NGS technologies asserted themselves as the fastest and most reliable way to detect Single Nucleotide Variants (SNV) and Copy Number Variations (CNV) in cancer patients. These technologies can be used to sequence DNA at very high depths thus allowing to detect abnormalities in tumor cells with very low frequencies. A lot of different variant callers are publicly available and usually do a good job at calling out variants. However, when frequencies begin to drop under 1%, the specificity of these tools suffers greatly as true variants at very low frequencies can be easily confused with sequencing or PCR artifacts. The recent use of Unique Molecular Identifiers (UMI) in NGS experiments offered a way to accurately separate true variants from artifacts. UMI-based variant callers are slowly replacing raw-reads based variant callers as the standard method for an accurate detection of variants at very low frequencies. However, benchmarking done in the tools publication are usually realized on real biological data in which real variants are not known, making it difficult to assess their accuracy.ResultsWe present UMI-Gen, a UMI-based reads simulator for targeted sequencing paired-end data. UMI-Gen generates reference reads covering the targeted regions at a user customizable depth. After that, using a number of control files, it estimates the background error rate at each position and then modifies the generated reads to mimic real biological data. Finally, it will insert real variants in the reads from a list provided by the user.AvailabilityThe entire pipeline is available athttps://gitlab.com/vincent-sater/umigen-masterunder MIT license.Contactvincent.sater@gmail.com
Published: 2020
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41. Risk of Rectovaginal Fistula in Women with Excision of Deep Endometriosis Requiring Concomitant Vaginal and Rectal Sutures, with or without Preventive Stoma: A Before-and-after Comparative Study

Author: Damien Forestier, Horace Roman, Eric Magne, Valérie Bridoux, Jean-Jacques Tuech, Myriam Noailles, Benoit Resch, Benjamin Merlot, Clinique Tivoli Ducos [Bordeaux], Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de chirurgie digestive [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)
Subjects: medicine.medical_specialty, Endometriosis, Rectum, Rectovaginal fistula, Stoma, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Stoma (medicine), medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, ComputingMilieux_MISCELLANEOUS, Retrospective Studies, 030219 obstetrics & reproductive medicine, Sutures, business.industry, Rectovaginal Fistula, Obstetrics and Gynecology, Odds ratio, Deep endometriosis, medicine.disease, 3. Good health, Surgery, medicine.anatomical_structure, Rectal Diseases, Treatment Outcome, 030220 oncology & carcinogenesis, Concomitant, Vagina, Anal verge, Disc excision, Female, business
Abstract: Study Objective To assess whether a liberal policy of preventive stoma (LPS) reduces the rate of rectovaginal fistulas in women with excision of deep endometriosis requiring concomitant vaginal and rectal sutures in comparison with a more restrictive policy of preventive stoma (RPS) and to assess the risk factors for rectovaginal fistula. Design Retrospective before-and-after comparative study. Setting Two referral centers, one with an LPS and the other with an RPS. Patients A total of 363 patients with deep endometriosis infiltrating the rectum and the vagina. Interventions Rectal disc excision or colorectal resection concomitantly with vaginal excision. Measurements and Main Results Two hundred forty-one and 122 women received surgery at the LPS and RPS centers, respectively. The rate of preventive stomas was 71.4% at the LPS center (n = 172) and 30.3% at the RPS center (N = 37). Rectovaginal fistula was recorded in 31 cases (8.5%): nineteen women were managed at the LPS center, and 12 women underwent surgery at the RPS center. It occurred in, respectively, 9.4%, 10.8%, 10.1%, and 7% of the women managed without and with a stoma at the RPS center and of those managed without and with a stoma at the LPS center (p = .72). The height of the rectal stapled line was significantly lower in the women undergoing a stoma, particularly in those managed at the RPS center (5.4 ± 1.8 cm). Performing rectal sutures within 8 cm from the anal verge increased the risk of rectovaginal fistula more than 3-fold, independently of stoma creation, surgical procedure carried out on the rectum, size of vaginal infiltration, or associated excision of deep endometriosis involving the pelvic nerves (odds ratio 3.4; 95% confidence interval, 1.3–9.1). Conclusion No statistically significant differences were found in terms of the risk of rectovaginal fistula between women with rectovaginal endometriosis managed by either an LPS or an RPS; however, these findings need to be confirmed by a randomized trial.
Published: 2022
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42. Eater profile and associated factors in pediatric patients of the PEDIANUT cohort

Author: Lyvia Tiburce, Thibaut Sabatier, Valérie Bertrand, Marie-Pierre Tavolacci, Pierre Déchelotte, Damien Dufour, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) (GHH), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de nutrition [CHU Rouen], CHU Rouen, and Normandie Université (NU)
Subjects: Male, Adolescent, 030309 nutrition & dietetics, media_common.quotation_subject, Cohort Studies, Feeding and Eating Disorders, 03 medical and health sciences, 0302 clinical medicine, Age groups, 030225 pediatrics, Surveys and Questionnaires, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Family history, Child, General Psychology, ComputingMilieux_MISCELLANEOUS, media_common, 2. Zero hunger, 0303 health sciences, Nutrition and Dietetics, business.industry, Infant, Appetite, Feeding Behavior, medicine.disease, 3. Good health, Eating disorders, Cohort, Eating behavior, Female, business, Clinical psychology
Abstract: Appetite traits have multifactorial origins. In association with environmental and genetic factors, they could become problematic and lead to Feeding or Eating Disorders (FED). As the DSM-5 classification is not suitable for pediatric FED, another way to describe eating behavior is to distinguish the clinical profiles of "small eater" and "big eater". The aim of this study was to identify socio-demographic and medical factors associated with these profiles, and to compare problematic and non-problematic profiles. From the Pedianut study, we analyzed socio-demographic, medical and family history data among 401 children according to 4 age groups (1 year n = 101, 1-6 years n = 99, 6-12 years n = 100, 12-18 years n = 101). The information collected on eating behavior made it possible to define small eater profile (SEP) and big eater profile (BEP) using predefined grids. BEP was more frequent in adolescents (35.6%), and SEP was more frequent in children aged 1-6 years (34.3%). BEP was associated with having separated parents, being male and the oldest sibling (p 0.05). Problematic BEP was associated with eating while watching television, being a girl, and having sensory disorders (p 0.05). SEP was associated, whatever age, with non-breastfeeding, chronic illness, psychological history, sensory disorders, language delays (in the 1-6 year age group), and family history of FED (in the adolescent group) (p 0.05). This analysis of factors associated with eater profile opens new perspectives for research on risk factors associated with eating traits, which warrants further study in larger populations to delineate transition from healthy to problematic eating.
Published: 2022
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43. Improving high-resolution copy number variation analysis from next generation sequencing using unique molecular identifiers

Author: Pierre-Julien Viailly, Caroline Bérard, Mathieu Viennot, Marie-Delphine Lanic, Elodie Bohers, Fabrice Jardin, Sylvain Mareschal, Hélène Dauchel, Philippe Ruminy, Thierry Lecroq, Vincent Sater, Dominique Penther, Sydney Dubois, Nicolas Vergne, Alison Celebi, Hervé Tilly, Vinciane Marchand, Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe Traitement de l'information en Biologie Santé (TIBS - LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Laboratoire de Mathématiques Raphaël Salem (LMRS), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Lecroq, Thierry, Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)
Subjects: Adult, Male, DNA Copy Number Variations, Population, Computational biology, Biology, lcsh:Computer applications to medicine. Medical informatics, Biochemistry, Genome, DNA sequencing, CNV calling, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Next generation sequencing, Humans, Copy-number variation, Prospective Studies, education, Molecular Biology, Gene, lcsh:QH301-705.5, 030304 developmental biology, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM], 0303 health sciences, education.field_of_study, Comparative Genomic Hybridization, Applied Mathematics, Methodology Article, Nucleic acid sequence, High-Throughput Nucleotide Sequencing, Sequence Analysis, DNA, Middle Aged, UMI, 3. Good health, Computer Science Applications, lcsh:Biology (General), 030220 oncology & carcinogenesis, lcsh:R858-859.7, DNA microarray, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Comparative genomic hybridization
Abstract: Background Recently, copy number variations (CNV) impacting genes involved in oncogenic pathways have attracted an increasing attention to manage disease susceptibility. CNV is one of the most important somatic aberrations in the genome of tumor cells. Oncogene activation and tumor suppressor gene inactivation are often attributed to copy number gain/amplification or deletion, respectively, in many cancer types and stages. Recent advances in next generation sequencing protocols allow for the addition of unique molecular identifiers (UMI) to each read. Each targeted DNA fragment is labeled with a unique random nucleotide sequence added to sequencing primers. UMI are especially useful for CNV detection by making each DNA molecule in a population of reads distinct. Results Here, we present molecular Copy Number Alteration (mCNA), a new methodology allowing the detection of copy number changes using UMI. The algorithm is composed of four main steps: the construction of UMI count matrices, the use of control samples to construct a pseudo-reference, the computation of log-ratios, the segmentation and finally the statistical inference of abnormal segmented breaks. We demonstrate the success of mCNA on a dataset of patients suffering from Diffuse Large B-cell Lymphoma and we highlight that mCNA results have a strong correlation with comparative genomic hybridization. Conclusion We provide mCNA, a new approach for CNV detection, freely available at https://gitlab.com/pierrejulien.viailly/mcna/ under MIT license. mCNA can significantly improve detection accuracy of CNV changes by using UMI.
Published: 2021
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44. Avoidance or adaptation of radiotherapy in patients with cancer with Li-Fraumeni and heritable TP53-related cancer syndromes

Author: Gaëlle Bougeard, Pierre-Yves Marcy, François Chevalier, Nadège Corradini, Nicolas Foray, Luc Ollivier, Daniel Orbach, Juliette Thariat, A. Beddok, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Accueil et Recherche en Radiobiologie des Ions Accélérés (ARIA), Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Service de pédiatrie, adolescents, jeunes adultes [Institut Curie], Institut Curie [Paris], Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Centre Léon Bérard [Lyon], Unité Ad Hoc INSERM 000008 'Radiations : Défense, Santé, Environnement' [Lyon] (Inserm U1296), Centre Léon Bérard [Lyon]-Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU), Radiations : Défense, Santé, Environnement [Lyon] (Inserm UA8), and Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Oncology, medicine.medical_specialty, Neoplasms, Radiation-Induced, medicine.medical_treatment, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Population, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Germline, Li-Fraumeni Syndrome, 03 medical and health sciences, 0302 clinical medicine, Neoplastic Syndromes, Hereditary, Internal medicine, Radioresistance, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], medicine, Humans, Genetic Predisposition to Disease, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Radiosensitivity, education, Proton therapy, Germ-Line Mutation, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, education.field_of_study, Particle therapy, Radiotherapy, business.industry, Cancer, medicine.disease, Prognosis, 3. Good health, Radiation therapy, 030220 oncology & carcinogenesis, Tumor Suppressor Protein p53, business
Abstract: International audience; The management of patients with cancer and Li-Fraumeni or heritable TP53-related cancer syndromes is complex because of their increased risk of developing second malignant neoplasms after genotoxic stresses such as systemic treatments or radiotherapy (radiosusceptibility). Clinical decision making also integrates the risks of normal tissue toxicity and sequelae (radiosensitivity) and tumour response to radiotherapy (radioresistance and radiocurability). Radiotherapy should be avoided in patients with cancer and Li-Fraumeni or heritable TP53 cancer-related syndromes, but overall prognosis might be poor without radiotherapy: radioresistance in these patients seems similar to or worse than that of the general population. Radiosensitivity in germline TP53 variant carriers seems similar to that in the general population. The risk of second malignant neoplasms according to germline TP53 variant and the patient's overall oncological prognosis should be assessed during specialised multidisciplinary staff meetings. Radiotherapy should be avoided whenever other similarly curative treatment options are available. In other cases, it should be adapted to minimise the risk of second malignant neoplasms in patients who still require radiotherapy despite its genotoxicity, in view of its potential benefit. Adaptations might be achieved through the reduction of irradiated volumes using proton therapy, non-ionising diagnostic procedures, image guidance, and minimal stray radiation. Non-ionising imaging should become more systematic. Radiotherapy approaches that might result in a lower probability of misrepaired DNA damage (eg, particle therapy biology and tumour targeting) are an area of investigation.
Published: 2021
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45. Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging

Author: Ivana Dabaj, Justine Ferey, Florent Marguet, Vianney Gilard, Carole Basset, Youssef Bahri, Anne-Claire Brehin, Catherine Vanhulle, France Leturcq, Stéphane Marret, Annie Laquerrière, Isabelle Schmitz-Afonso, Carlos Afonso, Soumeya Bekri, Abdellah Tebani, Department of neonatal pediatrics, Intensive Care and Neuropediatrics, Rouen University Hospital, Rouen University Hospital, Rouen University, Team 4 'NeoVasc' - INSERM U1245, Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de biochime métabolique [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Department of Pathology, Rouen University Hospital, Department of neurosurgery, Rouen University Hospital, Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA), Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Organique Fine (IRCOF), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of genetics and reference center for developmental disorders, Laboratoire de Génétique et biologie moléculaire, HUPC Cochin, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Schmitz, Isabelle, Team 4 NeoVasc - Region Team ERI 28 INSERM (Neovasc), Département de Pathologie [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Institut de Chimie Organique Fine (IRCOF), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), and Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, Pathology, Biopsy, Duchenne muscular dystrophy, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Child, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Multidisciplinary, biology, Phosphatidic acid, Middle Aged, Neuromuscular disease, Sphingomyelins, Child, Preschool, Phosphatidylcholines, Medicine, medicine.symptom, Dystrophin, Sphingomyelin, Adult, musculoskeletal diseases, medicine.medical_specialty, [CHIM.ANAL] Chemical Sciences/Analytical chemistry, Adolescent, Science, Phosphatidic Acids, Phosphatidylserines, Article, Mass spectrometry imaging, 03 medical and health sciences, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, medicine, Animals, Humans, Metabolomics, Muscle, Skeletal, Myopathy, 030304 developmental biology, Mass spectrometry, Metabolism, medicine.disease, Muscular Dystrophy, Duchenne, chemistry, biology.protein, Adenosine triphosphate, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy, characterized by muscle degeneration due to altered or absent dystrophin. DMD has no effective cure, and the underlying molecular mechanisms remain incompletely understood. The aim of this study is to investigate the metabolic changes in DMD using mass spectrometry-based imaging. Nine human muscle biopsies from DMD patients and nine muscle biopsies from control individuals were subjected to untargeted MSI using matrix-assisted laser desorption/ionization Fourier-transform ion cyclotron resonance mass spectrometry. Both univariate and pattern recognition techniques have been used for data analysis. This study revealed significant changes in 34 keys metabolites. Seven metabolites were decreased in the Duchenne biopsies compared to control biopsies including adenosine triphosphate, and glycerophosphocholine. The other 27 metabolites were increased in the Duchenne biopsies, including sphingomyelin, phosphatidylcholines, phosphatidic acids and phosphatidylserines. Most of these dysregulated metabolites are tightly related to energy and phospholipid metabolism. This study revealed a deep metabolic remodelling in phospholipids and energy metabolism in DMD. This systems-based approach enabled exploring the metabolism in DMD in an unprecedented holistic and unbiased manner with hypothesis-free strategies.
Published: 2021
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46. Angiogenesis imaging study using interim [18F] RGD-K5 PET/CT in patients with lymphoma undergoing chemotherapy: preliminary evidence

Author: Pierre Decazes, David Tonnelet, M. D. Pierre Bohn, Fabrice Jardin, Hervé Tilly, Pierre Vera, Vincent Camus, Sébastien Thureau, Stéphanie Becker, Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Lymphoma, Angiogenesis, FDG, PET/CT, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Population, R895-920, 030218 nuclear medicine & medical imaging, Medical physics. Medical radiology. Nuclear medicine, 03 medical and health sciences, 18F-RGD-K5, 0302 clinical medicine, K5, Medicine, Radiology, Nuclear Medicine and imaging, In patient, education, Original Research, Fluorodeoxyglucose, PET-CT, education.field_of_study, Chemotherapy, RGD, business.industry, medicine.disease, 3. Good health, 030220 oncology & carcinogenesis, business, Nuclear medicine, medicine.drug
Abstract: Background Our aim was to measure the impact of two cycles of standard chemotherapy on tumoural neoangiogenesis by [18F] fluorine arginine-glycine-aspartic (RGD-K5) positron emission tomography–computed tomography (PET) on patients presenting with lymphoma. Nineteen patients at Rouen’s Henri Becquerel Cancer Centre were prospectively included. Fluorodeoxyglucose (FDG) and RGD-K5 PET were performed before (C0) and after (C2) two cycles of chemotherapy. End-of-treatment FDG PET was performed for final evaluation. Maximum standardised uptake value (SUVmax), SUVmean, Metabolic Tumour Volume (MTV) and Angiogenic Tumour Volume (ATV) were measured for all lesions. RGD SUVmax and SUVmean were also analysed in 13 normal organs at C0 and C2. The patient’s treatment response was considered using the Deauville score (DS) at the end of FDG PET treatment (DS 1–3 were considered responders, and 4 and 5 non-responders). Results Eighteen patients had both C0 FDG and RGD PET. Twelve patients had both C2 FDG and RGD, completed the treatment protocol and were included in end-of-treatment analysis. No statistical difference was found in RGD uptake of normal organs before and after chemotherapy for SUVmax and SUVmean. On C0 RGD, apart from classical Hodgkin lymphoma (cHL; n = 5) and grey zone lymphoma (GZL; n = 1), other lymphoma sub-types (n = 12) had low RGD uptake (p p Conclusions Our study showed significant higher initial RGD uptake in patients presenting with cHL and GZL compared to NHL. Non-responder also had higher post-chemotherapy RGD uptake compared to responders. Issues raised by RGD uptake, particularly in cHL, are yet to be explored and need to be confirmed in a larger population.
Published: 2021
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47. How to raise the interest for neurogastroenterology among young gastroenterologists?

Author: Daniel Keszthelyi, Alexandre Nuzzo, Chloé Melchior, Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: NUTRIM - R2 - Liver and digestive health, University of Gothenburg (GU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-Gastroentérologie [CHU Rouen], Normandie Université (NU), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), Division of Gastroenterology and Hepatology, Department of Internal Medicine, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands., douville, sabine, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Charles Nicolle [Rouen]-CHU Rouen, and Université de Paris
Subjects: medicine.medical_specialty, IRRITABLE-BOWEL-SYNDROME, gastroenterology, News, DIAGNOSIS, DGBIs, DISEASE, 03 medical and health sciences, 0302 clinical medicine, neurogastroenterology, TWITTER, MANAGEMENT, Medicine, ComputingMilieux_MISCELLANEOUS, GI ANGLE, business.industry, The European Society, RESEARCH FELLOWSHIP, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, IBS patients, Neurogastroenterology, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, 3. Good health, PREVALENCE, Oncology, 030220 oncology & carcinogenesis, Family medicine, CLINICAL-RESEARCH, 030211 gastroenterology & hepatology, business
Abstract: International audience
Published: 2021
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48. Surgical Management by Disk Excision or Rectal Resection of Low Rectal Endometriosis and Risk of Low Anterior Resection Syndrome: A Retrospective Comparative Study

Author: Jean-Jacques Tuech, Loïc Marpeau, Horace Roman, Marilena Farella, Rachid Chati, Valérie Bridoux, Julien Coget, Benoit Resch, Clinique Tivoli Ducos [Bordeaux], CHU Rouen, Normandie Université (NU), Service de chirurgie digestive [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark, and douville, sabine
Subjects: medicine.medical_specialty, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Endometriosis, Rectum, LARS, Digestive symptoms, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Rectal resection, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Low rectum, ComputingMilieux_MISCELLANEOUS, Retrospective Studies, 030219 obstetrics & reproductive medicine, Rectal Neoplasms, business.industry, Obstetrics and Gynecology, Retrospective cohort study, Syndrome, Odds ratio, medicine.disease, Confidence interval, 3. Good health, Surgery, medicine.anatomical_structure, Rectovaginal fistula, 030220 oncology & carcinogenesis, Anal verge, Defecation, Segmental resection, business, Disk excision
Abstract: Study Objective: To assess the risk of low anterior resection syndrome (LARS) between women managed by either disk excision or rectal resection for low rectal endometriosis. Design: Retrospective study of a prospective database. Setting: University hospital. Patients: One hundred seventy-two patients managed by disk excision or rectal resection for deep endometriosis infiltrating the rectum
Published: 2021
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49. Depressive symptoms in higher education students during the first wave of the COVID-19 pandemic. An examination of the association with various social risk factors across multiple high- and middle-income countries

Author: T Abel, CM Van der Heijde, F Rabiee-Khan, Robert Tholen, MP Tavolacci, Joël Ladner, S Çoksan, E Wouters, Veerle Buffel, T Stathopoulou, Hajo Zeeb, Heide Busse, S. Van De Velde, Piet Bracke, G. Van Hal, Research of the Student Medical Service, C19 ISWS consortium, Centre for Population, Family and Health, Department of Sociology, University of Antwerp, Sint-Jacobsstraat 2-4, 2000, Antwerpen, Belgium., Student Health Services, University of Amsterdam, the Netherlands., Department of Psychology, Middle East Technical University, Üniversiteler Mahallesi, Dumlupınar Bulvarı No:1, 06800, Çankaya/Ankara, Turkey., Health & Demographic Research, Department of Sociology, Ghent University, Korte Meer 5, 9000, Gent, Belgium., Institute of Social and Preventive Medicine, Faculty of Medicine, Universität Bern, Mittelstrasse 43, 3012, Bern, Switzerland., Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstraße 30, 28213, Bremen, Germany., School of Health Sciences, Faculty of Health, Education & Life Sciences, Birmingham City University, Westbourne Road, Birmingham, B15 3TN, UK., National Centre for Social Research, 9 Kratinou & Athinas St., 10552, Athens, Greece., Department of Social Medicine, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium., Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Département d'épidémiologie et de promotion de la santé [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Antwerp (UA), Universiteit Gent = Ghent University (UGENT), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, and douville, sabine
Subjects: Health (social science), Higher education, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], education, 610 Medicine & health, Article, 03 medical and health sciences, Social support, 0302 clinical medicine, 360 Social problems & social services, Pandemic, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], 030212 general & internal medicine, Association (psychology), Depressive symptoms, ComputingMilieux_MISCELLANEOUS, H1-99, business.industry, Higher education students, COVID-19, Health Policy, Stressor, Public Health, Environmental and Occupational Health, Mental health, 3. Good health, 030227 psychiatry, Disadvantaged, Social sciences (General), Human medicine, Public aspects of medicine, RA1-1270, business, Psychology, Demography
Abstract: Higher-education students face substantial risks for developing depressive symptoms during the COVID-19 pandemic or experiencing exacerbated pre-existing depressive symptoms. This study uses data from the COVID-19 International Student Well-Being Study, which collected data through a non-representative convenience sample in 125 higher-education institutions (HEI) across 26 high- and middle-income countries (N: 20,103) during the first wave of the COVID-19 pandemic. It describes the prevalence of depressive symptoms in higher-education students. We find substantial cross-national variation in depressive symptoms, with lowest mean levels established in the Nordic countries and France, while highest mean levels of depressive symptoms were found in Turkey, South Africa, Spain and the USA. Elevated risk for depressive symptoms was found in female students, students with fewer social support resources and in a more disadvantaged socioeconomic position, and students with a migrant background. COVID-19 related stressors, such as reduced social contact, increased financial insecurity, and academic stress explained a relatively larger proportion of the variance in depressive symptoms compared to non-COVID-19 related stressors. This finding shows that not the pandemic itself, but rather the secondary effects of the pandemic relate to students' mental health. Our results enable HEIs to be better equipped to target groups that are particularly at risk during a pandemic.
Published: 2021
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50. Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers

Author: M.-P. Tavolacci, Tony Pereira, Thomas Duflot, Fabien Lamoureux, Frédéric Aubrun, Virginie Lvovschi, Robinson Joannides, Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Rouen, Normandie Université (NU), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), douville, sabine, and Hôpital Charles Nicolle [Rouen]-CHU Rouen
Subjects: Adult, Male, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Metabolite, Pharmacokinetic modeling, RM1-950, Absorption (skin), Pharmacology, 030226 pharmacology & pharmacy, Models, Biological, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Sex Factors, Pharmacokinetics, Healthy volunteers, Administration, Inhalation, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Medicine, Distribution (pharmacology), Humans, Pharmacology (medical), Computer Simulation, ComputingMilieux_MISCELLANEOUS, Morphine Derivatives, Dose-Response Relationship, Drug, Morphine, business.industry, Research, Nebulizers and Vaporizers, Articles, Middle Aged, Healthy Volunteers, 3. Good health, Bioavailability, Analgesics, Opioid, chemistry, Modeling and Simulation, Injections, Intravenous, Female, Therapeutics. Pharmacology, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: Intravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle. Despite its high efficacy, it is impacted by organizational constraints related to venous access. Nebulized (NEB) morphine may represent an alternative for titration but pharmacokinetic (PK) properties of short nebulization using routine devices need evaluation. Twenty‐seven healthy volunteers were included to receive NEB or i.v. morphine administration using increasing amounts according to Dixon’s reference method. Plasma morphine, morphine‐3‐glucuronide (M3G), and morphine‐6‐glucuronide (M6G) were quantified. PK modeling and simulations were performed using Monolix. Dixon’s method exhibited a significantly higher morphine dose regimen in the NEB group versus the i.v. group (6.2 [5.3–7.1] vs. 3.0 [2.0–4.0] mg, p < 0.001). Morphine, M3G, and M6G dose‐normalized exposure were significantly lower in the NEB group versus the i.v. group: morphine (19 [13–23] vs. 1044 [702–1266] µg min/L, p < 0.001), M3G (245 [162–287] vs. 3752 [2487–5165] µg min/L, p < 0.001) and M6G (28 [21–43] vs. 466 [370–723] µg min/L, p < 0.001). The model that best fitted the data consisted in a transit compartment for morphine absorption, three compartments for morphine distribution followed by multiple transit compartments (8.2 and 57.5‐min transit time for M3G and M6G, respectively) and a first order elimination for M3G and M6G. Morphine bioavailability in the NEB group was 3.5% using the i.v. group as reference. Administration route and sex significantly influenced morphine and metabolite PKs. This work aimed to evaluate the PKs of NEB morphine compared with the i.v. route. Despite a bioavailability to improve, NEB morphine administration using a routine device is suitable to plan morphine titration.
Published: 2021
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