1. Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas
- Author
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Giulia Ceglie, Giada Del Baldo, Emanuele Agolini, Martina Rinelli, Antonella Cacchione, Francesca Del Bufalo, Maria Vinci, Roberto Carta, Luigi Boccuto, Evelina Miele, Angela Mastronuzzi, Franco Locatelli, and Andrea Carai
- Subjects
Oncology ,medicine.medical_specialty ,Genetics of cancer ,Genetic counseling ,high grade gliomas ,cancer predisposition ,Review ,030204 cardiovascular system & hematology ,Pediatrics ,pediatric neuro-oncology ,03 medical and health sciences ,0302 clinical medicine ,Pediatric Neuro-Oncology ,030225 pediatrics ,Internal medicine ,medicine ,Target therapy ,genetics of cancer ,business.industry ,Cancer predisposition ,lcsh:RJ1-570 ,Cancer ,lcsh:Pediatrics ,medicine.disease ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Pediatrics, Perinatology and Child Health ,brain tumors ,business ,pediatric neuro- oncology ,Childhood brain tumor - Abstract
Pediatric High-Grade Gliomas (pHGG) are among the deadliest childhood brain tumors and can be associated with an underlying cancer predisposing syndrome. The thorough understanding of these syndromes can aid the clinician in their prompt recognition, leading to an informed genetic counseling for families and to a wider understanding of a specific genetic landscape of the tumor for target therapies. In this review, we summarize the main pHGG-associated cancer predisposing conditions, providing a guide for suspecting these syndromes and referring for genetic counseling.
- Published
- 2020
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