1. Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins
- Author
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Ajay Thankamony, Joseph A M J L Janssen, Thomas H. Scheike, Rikke Beck Jensen, David P Dunger, Pernille Poulsen, Klaus K. Holst, Anders Juul, and Internal Medicine
- Subjects
0301 basic medicine ,Blood Glucose ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Dizygotic twin ,Denmark ,030209 endocrinology & metabolism ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Diabetes mellitus ,Internal medicine ,Insulin Secretion ,medicine ,Diseases in Twins ,Twins, Dizygotic ,Humans ,Insulin ,Insulin-Like Growth Factor I ,Aged ,Glucose tolerance test ,medicine.diagnostic_test ,Anthropometry ,business.industry ,Confounding ,General Medicine ,Twins, Monozygotic ,Heritability ,Glucose Tolerance Test ,Middle Aged ,medicine.disease ,Twin study ,030104 developmental biology ,Insulin-Like Growth Factor Binding Protein 3 ,Diabetes Mellitus, Type 2 ,Cohort ,Linear Models ,Female ,Insulin Resistance ,business ,Cohort study - Abstract
Objective IGF-I may be a marker of later metabolic and cardiovascular disease. The interactions between IGF-I and glucose metabolism are multifactorial, and there is potential confounding from several secondary effects. In this study, we examined the interaction between IGF-I and glucose metabolism in a large cohort of clinically well-characterized elderly twins. Design A total of 303 twin pairs of the same gender (606 twins) were included in the study; 125 monozygotic and 178 dizygotic twin pairs. Methods A clinical examination including a standard oral glucose tolerance test (OGTT) and anthropometric measurements was performed. Results The heritability estimates were high for IGF-I and IGFBP-3 (h2: 0.65 (95% CI: 0.55–0.74) and 0.71 (0.48–0.94), respectively) and for insulin secretion (h2 = 0.56, P 2 = 0.14, P = 0.11). In a multiple regression analysis (adjusting for age, gender and twin status), there was a negative association between IGF-I and insulin sensitivity (B: −0.13, SE 0.03, P P Conclusions There was a high heritability for IGF-I and IGFBP-3, but a low heritability for insulin secretion and insulin sensitivity in a group of elderly twins. In addition, we found a strong negative relationship between IGF-I and insulin sensitivity, which did not seem to be strongly genetically determined.
- Published
- 2018