1. Perinatal HCV Transmission Rate in HIV/HCV Coinfected women with access to ART in Madrid, Spain
- Author
-
Sara Domínguez-Rodríguez, Luis Prieto, Carolina Fernández McPhee, Marta Illán-Ramos, José Beceiro, Luis Escosa, Eloy Muñoz, Iciar Olabarrieta, Francisco Javier Regidor, Miguel Ángel Roa, María Del Carmen Viñuela Beneítez, Sara Guillén, Maria Luisa Navarro-Gómez, José Tomás Ramos Amador, and Madrid Cohort of HIV-infected mother-infant pairs
- Subjects
RNA viruses ,Male ,Maternal Health ,Hcv transmission ,HIV Infections ,Hepacivirus ,Pediatrics ,Health Services Accessibility ,Families ,0302 clinical medicine ,Immunodeficiency Viruses ,Pregnancy ,Antiretroviral Therapy, Highly Active ,Epidemiology ,Medicine ,Public and Occupational Health ,030212 general & internal medicine ,Children ,Pathology and laboratory medicine ,Multidisciplinary ,Obstetrics ,Transmission (medicine) ,Hepatitis C virus ,Coinfection ,Obstetrics and Gynecology ,virus diseases ,Medical microbiology ,Viral Load ,Vaccination and Immunization ,Hepatitis C ,Cohort ,Viruses ,030211 gastroenterology & hepatology ,Female ,Pathogens ,Pediatric Infections ,Infants ,Research Article ,Adult ,medicine.medical_specialty ,Mother to child transmission ,Science ,Immunology ,Mothers ,Antiretroviral Therapy ,Microbiology ,Injection drug use ,03 medical and health sciences ,Antiviral Therapy ,Virology ,Retroviruses ,Humans ,Medicine and health sciences ,Biology and life sciences ,Flaviviruses ,business.industry ,Lentivirus ,Organisms ,Viral pathogens ,Infant, Newborn ,HIV ,Infant ,Retrospective cohort study ,medicine.disease ,Hepatitis viruses ,digestive system diseases ,Microbial pathogens ,Age Groups ,Spain ,People and Places ,Women's Health ,Population Groupings ,Preventive Medicine ,business ,Viral Transmission and Infection - Abstract
Background Maternal HIV coinfection is a key factor for mother-to-child transmission (MTCT) of HCV. However, data about HCV MTCT in HIV/HCV-coinfected pregnant women on combined antiretroviral treatment (ART) are scarce. This study assessed the HCV MTCT rate in the Madrid Cohort of HIV-infected women. Methods Retrospective study within the Madrid Cohort of HIV-infected pregnant women (2000-2012). Epidemiological, clinical and treatment related variables were analysed for the mother and infant pairs. HCV MTCT rate was determined. Results Three hundred thirty-nine HIV/HCV-coinfected women and their exposed infants were recorded. A total of 227 (67%) paired mother-children had available data of HCV follow-up and were included for the analysis. Sixteen children (rate 7.0%, 95%CI 3.7-10.4%) were HCV infected by 18 months of age, none of them coinfected with HIV. HIV/HCV-coinfected pregnant women were mostly of Spanish origin with a background of previous injection drug use. HCV-genotype 1 was predominant. The characteristics of mothers that transmitted HCV were similar to those that did not transmit HCV with respect to sociodemographic and clinical features. A high rate (50%) of preterm deliveries was observed. Infants infected with HCV were similar at birth in weight, length and head circumference than those uninfected. Conclusion MTCT rates of HCV among HIV/HCV-coinfected women on ART within the Madrid cohort were lower than previously described. However, rates are still significant and strategies to eliminate any HCV transmission from mother to child are needed.
- Published
- 2020