1. Relationships Between Clinico-Epidemiological Patterns of Invasive Meningococcal Infections and Complement Deficiencies in French South Pacific Islands (New Caledonia)
- Author
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Isabelle Missotte, Sylvie Laumond-Barny, Martine Noel, Pierre-Emmanuel Spasic, Ann-Claire Gourinat, Yann Barguil, Laurent Besson-Leaud, Cécile Veysseyre Balter, Elodie Descloux, Aurélie de Suremain, Jean-Paul Grangeon, Maguy Daures, Michele John, Olivier Simon, Direction des Affaires sanitaires et sociales de la Nouvelle-Calédonie [Nouméa] (DASS [Nouméa]), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre hospitalier territorial Gaston-Bourret [Dumbea] (CHT), Centre hospitalier territorial Gaston-Bourret [Nouméa], Institut Pasteur de Nouvelle-Calédonie, Réseau International des Instituts Pasteur (RIIP), and This work was supported by the New Caledonia Health Department.
- Subjects
Male ,Bacteremia ,Neisseria meningitidis, Serogroup B ,MESH: Meningococcal Infections ,0302 clinical medicine ,Medical microbiology ,MESH: Aged, 80 and over ,melanesian population ,MESH: Risk Factors ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,MESH: Child ,Epidemiology ,Immunology and Allergy ,risk factors ,030212 general & internal medicine ,Child ,MESH: Bacteremia ,Aged, 80 and over ,MESH: Aged ,0303 health sciences ,MESH: Middle Aged ,MESH: Meningitis, Meningococcal ,Middle Aged ,MESH: Infant ,3. Good health ,Geography ,Invasive meningococcal disease ,MESH: Young Adult ,Child, Preschool ,Female ,Neisseria meningitidis, Serogroup Y ,Adult ,Complement deficiency ,medicine.medical_specialty ,Adolescent ,Immunology ,MESH: Complement System Proteins ,Meningococcal Infections ,Meningitis, Meningococcal ,Meningococcal disease ,03 medical and health sciences ,Young Adult ,Neisseria meningitidis, Serogroup W-135 ,New Caledonia ,MESH: Neisseria meningitidis, Serogroup B ,medicine ,Humans ,Aged ,Retrospective Studies ,meningococcal disease ,MESH: Adolescent ,MESH: Humans ,030306 microbiology ,MESH: Child, Preschool ,Infant ,MESH: Adult ,MESH: Retrospective Studies ,Complement System Proteins ,MESH: Neisseria meningitidis, Serogroup W-135 ,medicine.disease ,MESH: New Caledonia ,MESH: Male ,Metropolitan France ,MESH: Neisseria meningitidis, Serogroup Y ,MESH: Female ,Demography - Abstract
International audience; PurposeInvasive Meningococcal Disease (IMD) is three fold more common in New Caledonia (NC) than in metropolitan France and many IMD cases (35.7 %) are due to Y and W135 serogroups. The purpose of our study was to identify IMD risk factors in NC.MethodsA retrospective study of all IMD cases that occurred in NC between 2005 and 2011 was conducted. Socio-environmental, clinical and biological data were collected. A search for immune deficiency was proposed to all cases. IMD presentation and outcome were compared according to meningoccal serogroups and the complement deficiency status (C-deficiency).ResultsSixty-six sporadic IMD cases (29 B serogroup, 20 Y or W135, 6 C, 1 A, 10 unknown) occurred in 64 patients often
- Published
- 2015
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