1. Parkinsonian signs are a risk factor for falls
- Author
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Chinwe Nwadiogbu, Whitney Fitts, Jason Karlawish, Nabila Dahodwala, and Helen L. Partridge
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Longitudinal study ,Time Factors ,Biophysics ,Neurological examination ,Risk Assessment ,Article ,Executive Function ,03 medical and health sciences ,Cognition ,0302 clinical medicine ,Parkinsonian Disorders ,Risk Factors ,medicine ,Humans ,Dementia ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Risk factor ,Gait ,Stroke ,Depression (differential diagnoses) ,Aged ,Retrospective Studies ,Aged, 80 and over ,Neurologic Examination ,medicine.diagnostic_test ,business.industry ,Incidence ,Rehabilitation ,Middle Aged ,Pennsylvania ,medicine.disease ,nervous system diseases ,Survival Rate ,Physical therapy ,Accidental Falls ,Female ,business ,030217 neurology & neurosurgery ,Follow-Up Studies ,Cohort study ,Fall prevention - Abstract
Background Parkinsonian signs are common, non-specific findings in older adults and associated with increased rates of dementia and mortality. It is important to understand which motor outcomes are associated with parkinsonian signs. Objectives To determine the role of parkinsonian signs on fall rates among older adults. Methods We conducted a longitudinal study of primary care patients from the University of Pennsylvania Health System. Adults over 55 years were assessed at baseline through surveys and a neurological examination. We recorded falls over the following 2 years. Parkinsonian signs were defined as the presence of 2 of 4 cardinal signs. Incident falls were compared between subjects with and without parkinsonian signs, and modified Poisson regression used to adjust for potential confounders in the relationship between parkinsonian signs and falls. Results 982 subjects with a mean age of 68 (s.d. 8.8) years participated. 29% of participants fell and 12% exhibited parkinsonian signs at baseline. The unadjusted RR for falls among individuals with parkinsonian signs was 1.36 (95% CI 1.05–1.76, p = 0.02). After adjusting for age, cognitive function, urinary incontinence, depression, diabetes, stroke and arthritis, individuals with parkinsonian signs were still 38% more likely to fall than those without parkinsonian signs (RR 1.38, 95% CI 1.04–1.82; p = 0.03). Falls among those with parkinsonian signs were more likely to lead to injury (53% vs 37%; p = 0.04). Conclusions Parkinsonian signs are a significant, independent risk factor for falls. Early detection of this clinical state is important in order to implement fall prevention programs among primary care patients.
- Published
- 2017