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International audience; Two areas of the occipitotemporal cortex show a remarkable hemispheric lateralization: written words activate the visual word form area (VWFA) in the left fusiform gyrus and faces activate a symmetrical site in the right hemisphere, the fusiform face area (FFA). While the lateralization of the VWFA fits with the leftward asymmetry of the speech processing network, origin of the rightward asymmetry for faces is still unclear. Using fMRI data from 64 subjects (including 16 monozygotic (MZ) and 13 dizygotic (DZ) twin pairs), we investigated how activations evoked by written words, faces, and spoken language are co-lateralized in the temporal lobe, and whether this organization reflects genetic factors or individual reading expertise. We found that the lateralization of the left superior temporal activation for spoken language correlates with the lateralization of occipitotemporal activations for both written words and faces. Behavioral reading scores also modulate the responses to words and faces. Estimation of genetic and environmental contributions shows that activations of the VWFA, the occipital face area, and the temporal speech areas are partially under genetic control whereas activation of the FFA is primarily influenced by individual experience. Our results stress the importance of both genetic factors and acquired expertise in the occipitotemporal organization.

International audience; Embodied views of cognition propose that concepts are grounded in sensorimotor experience. Diverse aspects of sensorimotor experience, like action and context information, could play a key role in the formation and processing of manipulable object concepts. Specifically, contextual information could help to link specific actions experienced with different object exemplars. In this study, the effects of action and context priming on superordinate and basic-level categorization of manipulable objects were directly contrasted in 7- and 9-year-olds and in adults. Across the ages, results revealed a differential effect of hand and scene primes on conceptual processing at the superordinate and basic levels; the disadvantage of superordinate over basic-level categorization was reduced in the context priming condition in comparison to the action priming condition. The nature and role of contextual knowledge are discussed from a cognitive and a neurophysiological point of view. Directions for further developmental research on concepts are also considered.

International audience; When we look at our spatial environment we have the feeling that the whole visual field is coloured, yet the density of cone photoreceptors decreases considerably as eccentricity increases. We investigated colour perception (coloured/noncoloured), colour naming and whether colour helps object recognition at eccentricities varying from 0 degrees to 80 degrees in healthy observers and patients with low vision. We found that colours can be perceived and even identified above chance at very large eccentricities (60 degrees). When asked to categorize coloured and grey level objects as edible/nonedible, both healthy observers and patients with low vision showed better performance for coloured edible objects at 50 degrees suggesting that colour is used for object recognition in conditions of degraded form perception.

International audience; The authors proposed a model of the control of interceptive action over a ground plane (Chardenon, Montagne, Laurent, & Bootsma, 2004). This model is based on the cancellation of the rate of change of the angle between the current position of the target and the direction of displacement (i.e., the bearing angle). While several sources of visual information specify this angle, the contribution of proprioceptive information has not been directly tested. In this study, the authors used a virtual reality setup to study the role of proprioception when intercepting a moving target. In a series of experiments, the authors manipulated proprioceptive information by using the tendon vibration paradigm. The results revealed that proprioception is crucial not only to locate a moving target with respect to the body but also, and more importantly, to produce online displacement velocity changes to intercept a moving target. These findings emphasize the importance of proprioception in the control of interceptive action and illustrate the relevance of our model to account for the regulations produced by the participants.

International audience; Three experiments were conducted to determine if the intention to perform motor sequences in the future results in similar patterns of activation and inhibition as observed for verbal scripts. In Experiments 1 and 2, intention was induced by informing one group that they would be tested on the tasks following acquisition; the other group was not informed of the retention test. Recognition tests administered prior to and after the retention test indicated a strong intention superiority effect. However, intention instructions provided either at the end of acquisition (Experiment 1) or before acquisition (Experiment 2) failed to impact acquisition or retention performance of the motor sequences, but did influence the latency of responding on the retention test. Experiment 3 was designed to replicate the results of Experiments 1 and 2 using a within-subjects design and extend these findings to observation. The results indicated that intention instructions resulted in a strong intention superiority effect for both the physical and observational practice participants, but the performance on the intentional tasks was enhanced only for the observational practice group.

International audience; We tested the ability of 18 patients with schizophrenia and 18 matched controls to filter non-pertinent information in orientation matching tasks. The non-pertinent information consisted of pictures conveying semantic information. The pertinent information consisted of oriented line-segments drawn inside pictures or was represented by the overall orientation of the picture itself. The results showed that non-pertinent information interfered with performance of control subjects in all tasks. In contrast, non-pertinent information interfered with the performance of patients with schizophrenia to the same extent as that of matched controls only when non-pertinent and pertinent information was physically mingled, but not when they were separated. Yet, patients processed non-pertinent information in all experiments, as shown by reversed interference effects when non-pertinent and pertinent information was physically separated. These results suggest a deficit at linking physically distinct visual information in patients with schizophrenia. Additionally, performance was more impaired in patients with schizophrenia than in control subjects when the amount of displayed information increased. The results suggest the coexistence, and a possible relationship between attentional deficits and impairments at linking distinct visual information in patients with schizophrenia.

International audience; Pi?n (1914, 1920, 1952) demonstrated that simple reaction time (SRT) decays as a hyperbolic function of luminance in detection tasks. However, whether such a relationship holds equally for choice reaction time (CRT) has been questioned (Luce, 1986; Nissen, 1977), at least when the task is not brightness discrimination. In two SRT and three CRT experiments, we investigated the function that relates reaction time (RT) to stimulus intensity for five levels of luminance covering the entire mesopic range. The psychophysical experiments consisted of simple detection, two-alternative forced choice (2 AFC) with spatial uncertainty, 2 AFC with semantic categorization, and 2 AFC with orientation discrimination. The results of the experiments showed that mean RT increases with task complexity. However, the exponents of the functions relating RT to stimulus intensity were found to be similar in the different experiments. This finding indicates that Pi?n's law holds for CRT as well as for SRT. It describes RT as a power function of stimulus intensity, with similar exponents, regardless of the complexity of the task.

International audience; The authors examined whether, by attending to physical properties of objects, participants can prevent the activation of semantic information. Participants received a reference object followed by a display containing both a matching target and a distractor. In Experiments 1 and 2, participants attended to motion and to surface texture, respectively. Some evidence for the processing of semantic information occurred. This result contrasted with a previous study in which no evidence for semantic information processing was apparent in a color matching task (M. Boucart & G.W. Humphreys, 1994). In Experiment 3, pictures were used with outline contours composed of randomly distributed red and green dots, one color being overrepresented. Participants matched pictures according to the dominant color. Evidence for semantic processing emerged. The authors suggest that these results cannot be explained in terms of attention operating differently on separate physiological channels. Instead it is proposed that what is crucial in activating stored object representations is whether the global configuration of the picture is processed.

International audience; Deep brain stimulation of the subthalamic nucleus (DBS) is a widely used surgical technique to suppress motor symptoms in Parkinson's disease (PD), and as such improves patients' quality of life. However, DBS may produce emotional disorders such as a reduced ability to recognize emotional facial expressions (EFE). Previous studies have not considered the fact that DBS and l-dopa medication can have differential, common, or complementary consequences on EFE processing. A thorough way of investigating the effect of DBS and l-dopa medication in greater detail is to compare patients' performances after surgery, with the two therapies either being administered ('on') or not administered ('off'). We therefore used a four-condition (l-dopa 'on'/DBS 'on', l-dopa 'on'/DBS 'off', l-dopa 'off'/DBS 'on', and l-dopa 'off'/DBS 'off') EFE recognition paradigm and compared implanted PD patients to healthy controls. The results confirmed those of previous studies, yielding a significant impairment in the detection of some facial expressions relative to controls. Disgust recognition was impaired when patients were 'off' l-dopa and 'on' DBS, and fear recognition impaired when 'off' of both therapies. More interestingly, the combined effect of both DBS and l-dopa administration seems much more beneficial for EFE recognition than the separate administration of each individual therapy. We discuss the implications of these findings in the light of the inverted U curve function that describes the differential effects of dopamine level on the right orbitofrontal cortex (OFC). We propose that, while l-dopa could "overdose" in dopamine the ventral stream of the OFC, DBS would compensate for this over-activation by decreasing OFC activity, thereby restoring the necessary OFC-amygdala interaction. Another finding is that, when collapsing over all treatment conditions, PD patients recognized more neutral faces than the matched controls, a result that concurs with embodiment theories.

Recognition of a particular individual occurs when we reactivate links between current perceptual inputs and the previously formed representation of that person. This recognition can be achieved by identifying, separately or simultaneously, distinct elements such as the face, silhouette, or voice as belonging to one individual. In humans, those different cues are linked into one complex conceptual representation of individual identity. Here we tested whether rhesus macaques ( Macaca mulatta ) also have a cognitive representation of identity by evaluating whether they exhibit cross-modal individual recognition. Further, we assessed individual recognition of familiar conspecifics and familiar humans. In a free preferential looking time paradigm, we found that, for both species, monkeys spontaneously matched the faces of known individuals to their voices. This finding demonstrates that rhesus macaques possess a cross-modal cognitive representation of individuals that extends from conspecifics to humans, revealing the adaptive potential of identity recognition for individuals of socioecological relevance.

International audience; Studies with adults have found a left bias in their perception of faces, which suggests a right hemisphere specialisation in processing facial information. Hemispheric asymmetry is observed during the first year of life but it is still unclear at what age such specialisation becomes adult-like during the prolonged period of face-processing development through childhood. In the present study we investigated the development of children's perceptions of gender and emotion using chimeric faces. Our results demonstrate that a right hemisphere bias, similar to that found in adults, is observed from 5 years of age. The results are discussed within a framework of developmental studies and we conclude that although children may be less efficient than adults at encoding faces, their basic manner of encoding is not fundamentally different from that of adults.

International audience; Human faces are the main emotion displayers. Knowing that emotional compared to neutral stimuli elicit enlarged ERPs components at the perceptual level, one may wonder whether this has led to an emotional facilitation bias toward human faces. To contribute to this question, we measured the P1 and N170 components of the ERPs elicited by human facial compared to artificial stimuli, namely non-humanoid robots. Fifteen healthy young adults were shown sad and neutral, upright and inverted expressions of human versus robotic displays. An increase in P1 amplitude in response to sad displays compared to neutral ones evidenced an early perceptual amplification for sadness information. P1 and N170 latencies were delayed in response to robotic stimuli compared to human ones, while N170 amplitude was not affected by media. Inverted human stimuli elicited a longer latency of P1 and a larger N170 amplitude while inverted robotic stimuli did not. As a whole, our results show that emotion facilitation is not biased to human faces but rather extend to non-human displays, thus suggesting our capacity to read emotion beyond faces.

International audience; CONTEXT: Cognitive control is highly affected in schizophrenia, but its overall functional architecture remains poorly understood. A recent study demonstrated that, in healthy subjects, cognitive control is functionally organized within the lateral prefrontal cortex (LPFC) as a cascade of representations ranging from premotor to anterior LPFC regions according to stimuli, the present perceptual context, and the temporal episode in which stimuli occur. OBJECTIVE: To determine the functional hierarchical organization of cognitive control within the LPFC in patients with schizophrenia. DESIGN: Case-control study. SETTING: Hospital-based research units. PARTICIPANTS: Fifteen schizophrenic patients and 14 controls. MAIN OUTCOME MEASURES: Behavioral performance and regional brain activity as measured by functional magnetic resonance imaging during a task, varying the amount of information conveyed by episodic and contextual signals. RESULTS: In patients and healthy controls, activity in caudal LPFC regions varied as episodic and contextual signals, whereas rostral LPFC regions only exhibited an episodic effect. However, patients made more errors than controls when information conveyed by contextual and episodic signals increased. These impairments were related to hypoactivation in caudal LPFC regions and hyperactivation in rostral LPFC regions, respectively. Activation in caudal LPFC regions negatively correlated with the disorganization syndrome score of patients. CONCLUSIONS: In schizophrenic patients, the architecture of cognitive control follows the cascading organization from rostral LPFC regions to caudal LPFC and premotor regions depending on the temporal framing of action and events. We found, however, that immediate contextual signals insufficiently bias the caudal LPFC activity required to select the appropriate behavioral representation. This specific deficit could thus alter the internal consistency of schizophrenic patients' behavior. To compensate for this weakening of contextual influence, schizophrenic patients may inefficiently use temporal episodic information through higher activation in rostral LPFC regions.

International audience; The other-race effect is a collection of phenomena whereby faces of one's own race are processed differently from those of other races. Previous studies have revealed a paradoxical mirror pattern of an own-race advantage in face recognition and an other-race advantage in race-based categorisation. With a well-controlled design, we compared recognition and categorisation of own-race and other-race faces in both Caucasian and Chinese participants. Compared with own-race faces, other-race faces were less accurately and more slowly recognised, whereas they were more rapidly categorised by race. The mirror pattern was confirmed by a unique negative correlation between the two effects in terms of reaction time with a hierarchical regression analysis. This finding suggests an antagonistic interaction between the processing of face identity and that of face category, and a common underlying processing mechanism.

International audience; This behavioral study aimed at assessing the effect of two variables on the degree of hemispheric specialization for language. One of them was the grapho-phonemic translation (transformation) (letter-sound mapping) and the other was the participants'gender. The experiment was conducted with healthy volunteers. A divided visual field procedure has been used to perform a phoneme detection task implying either regular (transparent) grapho-phonemic translation (letter-sound mapping consistency) or irregular (non-transparent) grapho-phonemic translation (letter-sound mapping inconsistency). Our results reveal a significant effect of grapho-phonemic translation on the degree of hemispheric dominance for language. The phoneme detection on items with transparent translation (TT) was performed faster than phoneme detection on items with non-transparent translation (NTT). This effect seems to be due to faster identification of TT than NTT when the items were presented in the left visual field (LVF)-right hemisphere (RH). There was no difference between TT and NTT for stimuli presented in the right visual field (RVF)-left hemisphere (LH). This result suggests that grapho-phonemic translation or the degree of transparency can affect the degree of hemispheric specialization, by modulating the right hemisphere activity. With respect to gender, male participants were significantly more lateralized than female participants but no interaction was observed between gender and degree of transparency.

Strong evidence suggests a role for nociceptin/orphanin FQ (N/OFQ) neuropeptide and its receptor (NOP) in cognition. However, the signaling mechanisms underlying N/OFQ modulation of memory are less understood. Here, we show that intracerebroventricular or intrahippocampal infusions of N/OFQ impair long-term memory formation in the mouse object recognition task. The synthetic NOP receptor agonist, (1S,3aS)-8-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one (Ro64-6198), administered systemically, also produced amnesic effects that were blocked by coinfusion of the NOP receptor antagonist, [Nphe1,Arg14,Lys15]nociceptin-NH2 (UFP-101), into the dorsal hippocampus. In contrast, Ro64-6198 had no effect on short-term memory or recall performances. Immunoblotting analysis revealed a strong suppressive action of Ro64-6198 on learning-induced upregulation of hippocampal extracellular signal-regulated kinase (ERK) phosphorylation, which is crucial for long-term information storage. Accordingly, pharmacological inhibition of ERK activation after systemic injection of SL327 [α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzene acetonitrile], a selective inhibitor of the upstream kinase MEK (mitogen-activated protein kinase kinase), abolished long-term recognition memory formation. The noncompetitive NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5,10-imine maleate (MK-801), given systemically, also suppressed ERK activation and disrupted recognition memory. In contrast, no effect of MK-801 was observed on recall, as for Ro64-6198. When administered concurrently at subthreshold doses, Ro64-6198 and MK-801 synergistically suppressed hippocampal ERK activation and impaired long-term memory formation. Under resting conditions, neither Ro64-6198 nor MK-801 affected spontaneous ERK activity in the hippocampus at the amnesic doses whereas at higher doses, only MK-801 had a suppressive effect. We conclude that N/OFQ-NOP receptor system negatively regulates long-term recognition memory formation through hippocampal ERK signaling mechanisms. This modulation may in part take place by inhibiting glutamatergic function at the NMDA receptor.

Recent studies have suggested that attention facilitates the formation of synchronous neural assemblies in the γ range (>40 Hz) to amplify behaviorally relevant signals. Whether this mechanism is general or confined to sensory cortices is still a matter of debate, since there is little evidence of a direct link between attention and increased γ synchronization in high‐level brain regions. We recorded the intracerebral EEG of 10 epileptic patients while manipulating their attention during reading, and compared the neural responses to attended and unattended words. Visual presentation of attended words induced γ band responses in the major brain regions associated with reading and those responses were attenuated for unattended words. The attenuation was not uniform within the reading network but followed a gradient from the posterior visual to the frontal areas. Altogether, these results support the view that the γ band response can be used as a quantitative marker of attention. Hum Brain Mapp 2008. © 2007 Wiley‐Liss, Inc.

A recent article in this journal (Hershler, O., & Hochstein, S. (2005). At first sight: A high-level pop out effect for faces. Vision Research, 45(13), 1707–1724) reported, in contradiction to several earlier studies, that photographs of human faces can be searched for efficiently (i.e., “pop out”) among photographs of other objects (as long as these objects are not “too similar” to faces). An apparent search asymmetry between faces and other categories (houses, cars) pointed to the existence of a specialized “face map”. Findings of impaired performance for scrambled images were presented as evidence that this face pop out is a high-level, “holistic” effect. While the main pop-out effect cannot be disputed, several choices made in that study in terms of experiment design, analysis and interpretation are questionable. After discussing these issues, I report novel experiments which show that (i) the face pop-out effect can be replicated, but under controlled conditions there is no asymmetry between faces and other objects (cars); (ii) inverting pictures and hence disrupting holistic face processing has only a minor effect on search performance; (iii) finally, search becomes inefficient when Fourier amplitude information (which carries global low-level statistical properties of images) is made irrelevant, and only phase information (carrying contour localization) can be used to detect faces. These results imply, contrary to the target article, that the face pop-out effect is mostly based on low-level factors.

International audience; Dynamical causal modeling (DCM) of evoked responses is a new approach to making inferences about connectivity changes in hierarchical networks measured with electro- and magnetoencephalography (EEG and MEG). In a previous paper, we illustrated this concept using a lead field that was specified with infinite prior precision. With this prior, the spatial expression of each source area, in the sensors, is fixed. In this paper, we show that using lead field parameters with finite precision enables the data to inform the network's spatial configuration and its expression at the sensors. This means that lead field and coupling parameters can be estimated simultaneously. Alternatively, one can also view DCM for evoked responses as a source reconstruction approach with temporal, physiologically informed constraints. We will illustrate this idea using, for each area, a 4-shell equivalent current dipole (ECD) model with three location and three orientation parameters. Using synthetic and real data, we show that this approach furnishes accurate and robust conditional estimates of coupling among sources and their orientations.

Recently developed psychophysical techniques permit the biasing of the processing of the stimulus by early visual channels so that responses reflect characteristics of either magno- or parvocellular pathways (Pokorny & Smith, 1997). We used such techniques to test psychophysically whether the global magnocellular dysfunction reported in schizophrenia also affects early processes. Seven schizophrenic patients and 19 normal controls participated. The task was a four-alternative forced-choice luminance discrimination, using a 2 × 2 configuration of four 1-deg squares. Target luminance threshold was determined in three conditions: the stimulus, including the target, was pulsed for 17 ms (pulse paradigm); the target was presented on a steady background of four squares (steady paradigm), or the target was presented alone (no background paradigm). We replicated previous results demonstrating magnocellular and parvocellular signatures in control participants. No evidence for an early magnocellular deficit could be detected as the thresholds of all schizophrenic observers were higher both in the steady paradigm (presumed magnocellular mediation) and in the pulse paradigm (presumed parvocellular mediation). Magnocellular dysfunction, if present in schizophrenia, must concern more integrated processes, possibly at levels at which parvocellular and magnocellular paths interact.

International audience; Neuronally plausible, generative or forward models are essential for understanding how event-related fields (ERFs) and potentials (ERPs) are generated. In this paper, we present a new approach to modeling event-related responses measured with EEG or MEG. This approach uses a biologically informed model to make inferences about the underlying neuronal networks generating responses. The approach can be regarded as a neurobiologically constrained source reconstruction scheme, in which the parameters of the reconstruction have an explicit neuronal interpretation. Specifically, these parameters encode, among other things, the coupling among sources and how that coupling depends upon stimulus attributes or experimental context. The basic idea is to supplement conventional electromagnetic forward models, of how sources are expressed in measurement space, with a model of how source activity is generated by neuronal dynamics. A single inversion of this extended forward model enables inference about both the spatial deployment of sources and the underlying neuronal architecture generating them. Critically, this inference covers long-range connections among well-defined neuronal subpopulations. In a previous paper, we simulated ERPs using a hierarchical neural-mass model that embodied bottom-up, top-down and lateral connections among remote regions. In this paper, we describe a Bayesian procedure to estimate the parameters of this model using empirical data. We demonstrate this procedure by characterizing the role of changes in cortico-cortical coupling, in the genesis of ERPs. In the first experiment, ERPs recorded during the perception of faces and houses were modeled as distinct cortical sources in the ventral visual pathway. Category-selectivity, as indexed by the face-selective N170, could be explained by category-specific differences in forward connections from sensory to higher areas in the ventral stream. We were able to quantify and make inferences about these effects using conditional estimates of connectivity. This allowed us to identify where, in the processing stream, category-selectivity emerged. In the second experiment, we used an auditory oddball paradigm to show that the mismatch negativity can be explained by changes in connectivity. Specifically, using Bayesian model selection, we assessed changes in backward connections, above and beyond changes in forward connections. In accord with theoretical predictions, there was strong evidence for learning-related changes in both forward and backward coupling. These examples show that category- or context-specific coupling among cortical regions can be assessed explicitly, within a mechanistic, biologically motivated inference framework.

We tested whether motion and configural complexity affect perceived transparency. A series of five coherent chromatic transformations in color space was applied across a figure: translation, convergence, shear, divergence and rotation. The stimuli consisted of a bipartite or a checkerboard configuration (10 × 10°), with a central static or moving overlay (5 × 5°). Three different luminance conditions (the plane of chromatic transformation oriented toward higher, lower, or equal luminances) were also tested for each of three modulation depths. For each stimulus, the observer judged whether the overlay appeared transparent or not. The main results indicated an interaction between the type of chromatic transformation and stimulus motion and complexity. For example, convergences are judged to appear transparent significantly more often when motion is added for bipartite configurations, or when they are generated in a checkerboard configuration. Surprisingly, shears that have been reported to appear opaque, are more frequently reported to appear transparent with short vector lengths and when combined with motion. Other transformations are also affected by motion, although the effectiveness of figural complexity on transparency seems to depend on both the type of color shifts and the presence of motion. The results indicate that adding motion and stimulus complexity are not necessarily neutral with respect to the chromatic shifts evoking transparency. Thus, studies that have used motion to enhance transparency may yield different results about the color shifts supporting transparency perception from those that did not. The same might be supposed for stimulus complexity under some conditions.

In normal viewing, the visual system effortlessly assigns approximately constant attributes of color and shape to perceived objects. A fundamental component of this process is the compensation for illuminant variations and intervening media to recover reflectance properties of natural surfaces. We exploited the phenomenon of transparency perception to explore the cortical regions implicated in such processes, using fMRI. By manipulating the coherence of local color differences around a region in an image, we interfered with their global perceptual integration and thereby modified whether the region appeared transparent or not. We found the major cortical activation due to global integration of local color differences to be in the anterior part of the parahippocampal gyrus. Regions differentially activated by chromatic versus achromatic geometric patterns showed no significant differential response related to the coherence/incoherence of local color differences. The results link the integration of local color differences in the extraction of a transparent layer with sites activated by object-related properties of an image.

International audience; We investigated the role of somatosensory feedback during bimanual coordination by testing a bilaterally deafferented patient, a unilaterally deafferented patient, and three control participants on a repetitive bimanual circle-drawing task. Circles were drawn symmetrically or asymmetrically at varying speeds with full, partial, or no vision of the hands. Strong temporal coupling was observed between the hands at all movement rates during symmetrical drawing and at the comfortable movement rate during asymmetrical drawing in all participants. When making asymmetric movements at the comfortable and faster rates, the patients and controls exhibited similar evidence of pattern instability, including a reduction in temporal coupling and trajectory deformation. The patients differed from controls on measures of spatial coupling and variability. The amplitudes and shapes of the two circles were less similar across limbs for the patients than the controls and the circles produced by the patients tended to drift in extrinsic space across successive cycles. These results indicate that somatosensory feedback is not critical for achieving temporal coupling between the hands nor does it contribute significantly to the disruption of asymmetrical coordination at faster movement rates. However, spatial consistency and position, both within and between limbs, were disrupted in the absence of somatosensory feedback.

International audience; The authors investigated whether the salience of dynamic visual information in a video-aiming task mediates the specificity of practice. Thirty participants practiced video-aiming movements in a full-vision, a weak-vision, or a target-only condition before being transferred to the target-only condition without knowledge of results. The full- and weak-vision conditions resulted in less endpoint bias and variability in acquisition than did the target-only condition. Going from acquisition to transfer resulted in a large increase in endpoint variability for the full-vision group but not for the weak-vision or target-only groups. Kinematic analysis revealed that weak dynamic visual cues do not mask the processing of other sources of afferent information; unlike strong visual cues, weak visual cues help individuals calibrate less salient sources of afferent information, such as proprioception.

International audience; OBJECTIVE: Using functional MRI, we investigated whether, like healthy subjects, patients with schizophrenia show a relative hemispheric specialization in ventrolateral prefrontal cortex (PFC) for spatial and shape working memory (WM). We hypothesized that reduced specialization in schizophrenia would reflect a failure to adopt optimal domain-specific strategies and would contribute to WM deficits. METHODS: Twelve healthy subjects and 16 schizophrenia patients performed spatial and shape WM tasks and a non-WM control task. Direct comparisons of the spatial and shape WM tasks assessed specialization. RESULTS: Despite deficient WM performance, both patients and controls showed a relative hemispheric specialization in ventrolateral PFC for spatial (right) and shape (left) WM and did not differ in this regard. CONCLUSIONS: The finding of intact hemispheric specialization in ventrolateral PFC suggests that patients employ the same domain-specific strategies as healthy subjects during spatial and shape WM. Rather than reflecting a failure to adopt the optimal strategy, we hypothesize that WM deficits in schizophrenia reflect impairments of executive processes that are required for WM performance regardless of domain. These processes are associated with activity in the dorsolateral PFC, a region that has been repeatedly implicated in studies of WM.

There is ongoing debate about whether performance on tests of recognition memory can remain preserved after hippocampal damage. In the present study, we report F.R.G., a patient who became severely amnesic following herpes simplex encephalitis. Although F.R.G. failed all tests involving recall and verbal recognition, she obtained normal performance on a wide number of tests evaluating visual recognition memory (14 of 18 different tests). Her performance was independent of various factors, such as test difficulty, duration of exposure to the stimuli, or delay separating encoding and recognition. F.R.G. also achieved normal performance on two tasks requiring that she associate pairs of visual stimuli. In addition, she demonstrated spared feeling of knowing, suggesting that her performance on recognition tests was explicit and likely to rely on familiarity. Brain imaging (MRI) revealed bilateral lesions of the hippocampus and lesions of the left parahippocampal gyrus, while the right parahippocampal gyrus remained relatively spared. The results of this study support the view that recognition memory can be preserved despite severe hippocampal damage and that familiarity is a distinct memory process that can be dissociated from recollection.

International audience; How are word recognition circuits organized in the left temporal lobe? We used functional magnetic resonance imaging (fMRI) to dissect cortical word-processing circuits using three diagnostic criteria: the capacity of an area (1) to respond to words in a single modality (visual or auditory) or in both modalities, (2) to modulate its response in a top-down manner as a function of the graphemic or phonemic emphasis of the task, and (3) to show repetition suppression in response to the conscious repetition of the target word within the same sensory modality or across different modalities. The results clarify the organization of visual and auditory word-processing streams. In particular, the visual word form area (VWFA) in the left occipitotemporal sulcus appears strictly as a visual unimodal area. It is, however, bordered by a second lateral inferotemporal area which is multimodal [lateral inferotemporal multimodal area (LIMA)]. Both areas might have been confounded in past work. Our results also suggest a possible homolog of the VWFA in the auditory stream, the auditory word form area, located in the left anterior superior temporal sulcus.

Erratum in J Neurosci. 2002 Dec 15;22(24):1a.. Blaizot A Xavier [corrected to Blaizot Xavier].; International audience; In Alzheimer's disease (AD), the rhinal cortex is the area earliest and most affected by neurofibrillary tangles, and the degree of temporoparietal glucose hypometabolism and rhinal cortex atrophy are both correlated with dementia severity. In monkeys, damage to the rhinal cortex leads to severe impairment in declarative memory, which is also affected preferentially in early AD. To investigate the contribution of rhinal alterations to the interrelationships between cerebral hypometabolism and declarative memory impairment observed in AD, we studied the effects of excitotoxic bilateral rhinal lesions in baboons on cerebral glucose consumption (CMRglc) as measured by positron emission tomography and performance on a visual recognition memory task as assessed in parallel by a delayed nonmatching-to-sample task. We reported previously that these rhinal lesions induce both a long-lasting hypometabolism in several remote brain regions (Meguro et al., 1999) and impaired memory performance (Chavoix et al., 2002). The present analysis indicates that across lesioned and sham baboons, memory scores were significantly positively correlated (p < 0.05; Spearman) with concomitant CMRglc values of several brain areas, such as neocortical associative and posterior hippocampal regions. These findings, reminiscent of those reported in AD, suggest that the neurodegenerative process that affects the rhinal cortex in early AD plays a crucial role in the pattern of brain hypometabolism and consequently in the declarative memory impairments characteristic of this disease.

It is widely accepted that developmental dyslexia results from some sort of phonological deficit. Yet, it can be argued that phonological representations and their processing have been insufficiently tested in dyslexia research. Firstly, claims about how tasks tap into certain kinds of representations or processes are best appreciated in the light of an explicit information-processing model. Here, a cognitive model of lexical access is described, incorporating speech perception, reading and object recognition. The model emphasises that phonological forms of lexical items are distinct from non-lexical phonological representations Secondly, phonology, as a linguistic discipline, teaches us that there is much more to it than phonemic categorisation and awareness. The phonological level of representation also embodies phonotactic regularities, patterns of phoneme assimilation and alternation, as well as supra-segmental knowledge pertaining to syllable structure, stress, intonation and rhythm. All those aspects are in part language-dependent, and therefore must be learnt by children in order to become proficient native speakers and listeners. If all levels of phonological representations were affected in dyslexia, dyslexic children would presumably have difficulties acquiring these aspects of their language. This prediction is as yet untested. A possible research agenda is outlined, aiming to provide a more comprehensive assessment of the phonological theory of dyslexia.

The short response latencies of face selective neurons in the inferotemporal cortex impose major constraints on models of visual processing. It appears that visual information must essentially propagate in a feed-forward fashion with most neurons only having time to fire one spike. We hypothesize that flashed stimuli can be encoded by the order of firing of ganglion cells in the retina and propose a neuronal mechanism, that could be related to fast shunting inhibition, to decode such information. Based on these assumptions, we built a three-layered neural network of retino-topically organized neuronal maps. We showed, by using a learning rule involving spike timing dependant plasticity, that neuronal maps in the output layer can be trained to recognize natural photographs of faces. Not only was the model able to generalize to novel views of the same faces, it was also remarkably resistant to image noise and reductions in contrast.

International audience; The attentional blink has been attributed to capacity limitations at a central level of processing. We tested whether failure to identify the target would eliminate the blink. Two agnostic patients were presented with streams of letters, which they were able to identify, and streams of pictures, which they were unable to identify. The dual-task involved identification of a target and detection of a probe. With letters the duration of the blink was equivalent to that of the control subjects. A prolonged blink was observed in both patients for pictures irrespective of whether the target was identified. This result indicates that failure to identify the target does nevertheless mobilize attentional resources sufficiently to prevent detection of a second target stimulus.

Although it is largely accepted that visual-mental imagery and perception draw on many of the same neural structures, the existence and nature of neural processing in the primary visual cortex (or area V1) during visual imagery remains controversial. We tested two general hypotheses: The first was that V1 is activated only when images with many details are formed and used, and the second was that V1 is activated whenever images are formed, even if they are not necessarily used to perform a task. We used event-related functional magnetic resonance imaging (ER-fMRI) to detect and characterize the activity in the calcarine sulcus (which contains the primary visual cortex) during single instances of mental imagery. The results revealed reproducible transient activity in this area whenever participants generated or evaluated a mental image. This transient activity was strongly enhanced when participants evaluated characteristics of objects, whether or not details actually needed to be extracted from the image to perform the task. These results show that visual imagery processing commonly involves the earliest stages of the visual system.

International audience; Cerebral activity during number comparison was studied with functional magnetic resonance imaging using an event-related design. We identified an extended network of task-related areas that showed a phasic activation following each trial, including anterior cingulate, bilateral sensorimotor areas, inferior occipito-temporal cortices, posterior parietal cortices, inferior and dorsolateral prefrontal cortices, and thalami. We then tested which of these areas were affected by number notation, numerical distance and response side, three variables that specifically target processes of visual identification, quantity manipulation and motor response in a serial-stage model of the number comparison task. Our results confirm the role of the right fusiform gyrus in digit identification processes, and of the inferior parietal lobule in the internal manipulation of numerical quantities.

International audience; Two observers practised to detect small target lines of varying luminance presented either within a context of collinear inducing stimuli, or without the context in separate blocks. A two-alternative spatial-forced-choice procedure using the method of constant stimuli was employed. For blocks of 500 trials, reflecting individual performance on five successive days of training, the percentage of correct responses, and the response times were analyzed. After several thousands of trials, i.e. several weeks of practice, both observers managed to detect targets presented at their strongest luminance within the context condition. Without the context, these targets remained undetected. Response times (RT) vary nonsystematically during training. Once detection is observed at the highest target luminance, the accuracy of the individual responses (percentage of correct responses) systematically increases, and processing speed (RT) systematically decreases with increasing target intensity. These results show that, within the appropriate perceptual context, practice can lead to a better detectability of visual stimuli presented at luminance levels near detection threshold. This improvement is reflected by an optimization of the visual integration of the different luminance levels of the target (sensory coding), and processing speed (response routine) during training.

International audience; We studied how the visual system integrates locally ambiguous velocities into global unambiguous coherent motion in the presence or absence of a textured background. Line drawings of complex figures were presented through invisible (i.e. same luminance and hue as the background) circular apertures such that only straight line segments were visible. These figures were either presented against a uniform background or embedded in static textures made of similar line segments in such a way that figures cannot be detected if they remain static. Under our experimental conditions, the figures translated clockwise or counterclockwise along a circular path and observers were required to discriminate the global direction of motion. Because of the aperture problem, a single moving segment cannot disambiguate the global direction of the figures and integration across multiple line segments is therefore necessary to perform the task. We found that with figures at high contrast, the presence of a texture enhanced direction discrimination, while direction discrimination of figures at low contrast was impaired by the presence of the texture. These paradoxical effects of a static texture were further tested by manipulating the relative contrast between figures and texture, the motion onset asynchrony (the delay between stimulus onset and motion onset or MOA), the density, the orientation and the distribution of texture elements. The effects of the texture, either facilitation or suppression, increase with texture contrast. Accuracy improves with MOA and decreases with texture density. In general, at high figure contrast, accuracy is better whenever referents are present in the image. We suggest that facilitation by the texture at high figure contrast is accounted for by reduced salience of segmentation cues such as line terminators and increased accuracy of local velocity measurements. On the other hand, decreased performance at low figure contrast may reflect lateral suppression of the responses to motion signals by the texture.

International audience; We measured contrast detection thresholds for a small (3.6 x 3.6 arc min) square target in the presence and absence of spatially identical pedestal stimuli, and of a spatially non-overlapping inducing line (3.6 x 23 arc min). Results for the pedestal stimuli replicated the classical "dipper function", thresholds being reduced by near-threshold pedestals and increased at higher pedestal contrasts. An inducer without a pedestal also decreased detection thresholds. When the inducer and pedestal were combined, their effects were additive. Thus the inducer facilitated target detection when the pedestal was absent but raised detection thresholds when the pedestal contrast was sufficient by itself to lower threshold. Inducers of opposite polarity to the target did not consistently decrease target thresholds, even when they were clearly visible, arguing against spatial uncertainty as the explanation of the inducer effect. The inducer effect was independent of the length of the inducer except with small (< 3.6 arc min) stimuli, and was abolished by increasing target-inducer separation beyond about 10 arc min.

International audience; In two experiments, brightness enhancement of the illusory surface in the Kanizsa square was investigated by means of a brightness matching procedure. The results show that specific properties of the inducing elements such as size, spacing, and luminance have effects on the matching threshold that are similar to those previously obtained in experiments on simultaneous contrast. The data from a third experiment demonstrate that increment thresholds measured within the Kanizsa square are elevated when the target is flashed on a position close to the inducing elements. The thresholds decrease considerably in the center of both test and control figures (representing or not representing an illusory square). These observations suggest that low-level mechanisms are likely to explain local brightness differences within the configurations but not global figure brightness. In other words, local contrast seems to generate brightness information that "sketches out" surfaces at their surrounds but does not "fill" them "in."

International audience; Three experiments tested how structural information affects the processing of fragmented forms, using evidence from both normal subjects and an agnosic patient. The stimuli were either (a) outline drawings of objects; (b) "well" or "poorly" structured fragmented forms derived from outline drawings (Experiments 1 and 2) or (c) "well" or "poorly" structured fragmented forms derived from outline drawings of meaningless forms (Experiment 3). "Well" and "poorly" structured forms varied on the properties of collinearity and closure of the elements. Subjects decided if two simultaneously presented forms had the same orientation or were mirror-reversed. Three levels of discriminability were examined: (a) for "symmetrical" forms the decision had to be based on the detection of a small feature appearing on the same or the opposite side in the two forms; (b) for "asymmetrical" forms the decision had to be based on a large part located on the same or the opposite side of each object; and (c) for "oblique" forms, matching could be based on the global orientation of the shapes. Normal subjects performed equivalently on outline drawings and "well" structured fragmented forms and worse on "poorly" structured forms. This effect was strongest on "asymmetrical" stimuli, both with meaningful (Experiments 1 and 2) and meaningless forms (Experiment 3). This indicates that the segmentation of forms into parts, for judgements with "asymmetrical" stimuli, is affected by the structural properties of collinearity and closure. For the agnosic patient, performance was similar for "well" and "poorly" structured forms, and there was better performance in the "oblique" condition. This suggests that the patient could use global shape information, but that this coexists with a selective deficit in computing local perceptual structure, based on collinearity and closure between form elements. The implications of the results for understanding form perception and the clinical use of fragmented forms, are discussed.

International audience; BACKGROUND: It is well known that facial expressions represent important social cues. In humans expressing facial emotion, fear may be configured to maximize sensory exposure (e.g., increases visual input) whereas disgust can reduce sensory exposure (e.g., decreases visual input). To investigate whether such effects also extend to the attentional system, we used the "attentional blink" (AB) paradigm. Many studies have documented that the second target (T2) of a pair is typically missed when presented within a time window of about 200-500 ms from the first to-be-detected target (T1; i.e., the AB effect). It has recently been proposed that the AB effect depends on the efficiency of a gating system which facilitates the entrance of relevant input into working memory, while inhibiting irrelevant input. Following the inhibitory response on post T1 distractors, prolonged inhibition of the subsequent T2 is observed. In the present study, we hypothesized that processing facial expressions of emotion would influence this attentional gating. Fearful faces would increase but disgust faces would decrease inhibition of the second target. METHODOLOGY/PRINCIPAL FINDINGS: We showed that processing fearful versus disgust faces has different effects on these attentional processes. We found that processing fear faces impaired the detection of T2 to a greater extent than did the processing disgust faces. This finding implies emotion-specific modulation of attention. CONCLUSIONS/SIGNIFICANCE: Based on the recent literature on attention, our finding suggests that processing fear-related stimuli exerts greater inhibitory responses on distractors relative to processing disgust-related stimuli. This finding is of particular interest for researchers examining the influence of emotional processing on attention and memory in both clinical and normal populations. For example, future research could extend upon the current study to examine whether inhibitory processes invoked by fear-related stimuli may be the mechanism underlying the enhanced learning of fear-related stimuli.

International audience; Two experiments were carried out to investigate the influence of structural and semantic information in the categorisation of visual forms. In experiment 1 the stimuli were pairs of 'well structured' or 'poorly structured' fragmented forms differing in structural properties including convexity, collinearity, and closure of the elements, and in their 'nameability'. The influence of structural and semantic information was tested by means of a task involving the presentation to both visual hemifields separately of stimuli having within-category physical similarity. For well structured forms, subjects were asked to judge if two sequentially presented forms belonged to the same semantic category. For poorly structured forms, subjects were required to decide if two stimuli belonged to the same previously learnt category of forms. For the two types of stimuli, one category was composed of physically similar items, and the other was composed of physically dissimilar items. The results show a marked advantage for the category composed of physically similar forms when the stimuli are well structured but no differences between the two categories when the stimuli are poorly structured. This suggests a facilitation in the computation of global shape information for forms having collinear and closed elements. The only effect of semantic information was a tendency towards a right visual field advantage for same-category pairs of well structured forms. The pattern of results for well structured fragmented forms (experiment 1) and forms in which fragments had been joined in order to complete the contour (experiment 2) were similar, suggesting that structured incomplete forms can be processed in the same way as forms having a continuous contour. Hypotheses about the organisational processes of forms are proposed in the discussion.

International audience; The occurrence of geometric orientation illusions and the perception of ambiguous figures were analyzed in 24 subjects during static body tilt relative to gravity on Earth. Results showed that illusions such as the Rock's diamond/square, the Ponzo illusion, and orientation contrast illusions occurred less frequently, and that depth reversal of ambiguous figures took more time when subjects were lying on their side or supine compared to upright, thus suggesting that the gravitational reference plays a significant role in these "visual" illusions. The structure of images, our representation of the environment, and orientation relative to gravity are all integral parts in interpreting visual images. In a weightless environment where no gravitational reference can be used, it is expected that similar alterations in visual perception will occur.