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Background: To assess the refractive status of cataract patients with extreme myopia and to measure their accommodative capability after monofocal IOL implantation. Design: Prospective non-randomized study conducted at Tianjin Medical University Eye Centre. Participants: 18 patients with 34 extreme myopic eyes (≥-10 Diopter, ≥27mm axial length), and 14 patients with 27 non-myopic eyes that had uneventful phacoemulsification and monofocal IOL implantation. Methods: The accommodation amplitude of the two groups was compared pre- and post-operatively using subjective minus-lenses-to-blur method. In the extreme myopic group, the postoperative target refraction was selected to be myopic, and they were evaluated for predicted postoperative spherical power consistency. Extreme myopic eyes anterior chamber depth was measured by pentacam, and axial length was measured by the immersion vector A/B-scan biometry. All measurements were done preoperatively and at 1, 3, 6 months postoperatively. Main Outcome Measures: Predicted spherical power, amplitude of accommodation, anterior chamber depth, axial length. Results: There was a significant difference between pre and postoperative results of Mean predicted spherical power (P=0.001). The differences between pre- and postoperative anterior chamber depth measurements were statistically significant (P=0.001). No significant differences were detected between pre- and postoperative measurements of axial length (P＞0.05). There was no significant difference in amplitude of accommodation between the two groups pre or postoperatively ( P＞0.05). Conclusions: The study yielded a hyperopic shift of the predicted postoperative spherical power of extreme myopic eyes. No significant difference was observed between extreme myopic and non-myopic eyes in

The aim of the present study was to investigate the association between blood reflux in Schlemm's canal (SC) and the decrease of intraocular pressure (IOP) after selective laser trabeculoplasty (SLT) in primary open-angle glaucoma (POAG). To verify this, 35 eyes from 25 POAG patients were enrolled. All eyes underwent 360° whole-circle gonioscopy via a three-mirror lens, prior to undergoing 360° SLT. The four quadrants of the examined eye were individually compressed by the lens, and the presence of blood reflux in SC after removal of the pressure was recorded. Eyes with no blood reflux in any quadrant were assigned to the negative group, while the others were assigned to the positive group. Patients were evaluated at baseline, at 1 and 2 weeks, and at 1, 3 and 6 months after SLT. The results indicated that in the reflux-positive (21 eyes) and -negative (14 eyes) group, a significant IOP decrease was seen at 1 and 2 weeks, and at 1 and 3 months after SLT as compared with that pre-SLT IOP (P0.05), while the positive group still exhibited a significant decrease in IOP compared with that at baseline (P

The aim of this study was to determine whether differences exist in oxygen supply to the optic nerve head (ONH) from the retinal and choroidal vascular layers in patients with primary open angle glaucoma (POAG) using multispectral imaging (MSI).This ia an observational, cross-sectional study. Multispectral images were acquired from 38 eyes of 19 patients with POAG, and 42 healthy eyes from 21 matched volunteers with Annidis’ RHA multispectral digital ophthalmoscopy. Superficial and deeper oxygen saturation of the optic disc was represented by the mean gray scale values on the retinal and choroidal oxy-deoxy maps, respectively. Statistical analysis was performed to detect differences in ONH oxygen saturation between the 2 groups. Oxygen saturation levels in the eyes of POAG patients with severe glaucoma were compared to those of fellow eyes from the same subjects. Linear correlation analysis was performed to assess the association between ONH oxygen saturation and systemic and ocular parameters. No statistical difference was found in retinal and choroidal oxygen saturation between the POAG and control groups. In the glaucoma patients, retinal oxygen saturation was lower for eyes with worse visual fields than in those with good visual fields (t = 4.009, P = 0.001). In POAG patients, retinal oxygen saturation was dependent on mean defect of visual field and retinal nerve fiber layer thickness (RNFLT) (r = 0.511, 0.504, P = 0.001, 0.001, respectively), whereas the choroid vasculature oxygen saturation was inversely related to RNFLT (r = −0.391, P = 0.015). An age-dependent increase in retinal oxygen saturation was found for both the POAG and control groups (r = 0.473, 0.410, P = 0.007, 0.003, respectively). MSI revealed a significant correlation between functional and structural impairments in glaucoma and retinal oxygen saturation. MSI could provide objective assessments of perfusion impairments of the glaucomatous ONH. This is a preliminary indication of the effectiveness of MSI for studying POAG.