1. Long noncoding RNA TP73-AS1 in human cancers
- Author
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Feihu Chu, Haiyan Miao, and Lusha Xue
- Subjects
0301 basic medicine ,Competing endogenous RNA ,Mechanism (biology) ,Biochemistry (medical) ,Clinical Biochemistry ,RNA ,Cancer ,Endogeny ,General Medicine ,Biology ,medicine.disease ,Biochemistry ,Long non-coding RNA ,Biomarker (cell) ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Neoplasms ,030220 oncology & carcinogenesis ,Cancer research ,medicine ,Humans ,RNA, Long Noncoding ,Function (biology) - Abstract
Long noncoding RNAs (lncRNAs) play an important role in tumor development. With the development of sequencing technology, many new lncRNAs have been discovered. lncRNA TP73-AS1 is abnormally expressed in many cancers. A summary of the current literature related to TP73-AS1 reveals that TP73-AS1 mainly regulates the occurrence and development of tumors through the mechanism of competitive endogenous RNA (ceRNA). In addition, the abnormal expression of TP73-AS1 can regulate the malignant function of tumor cells through a variety of possible mechanisms. All evidence suggests that TP73-AS1 may be a potential diagnostic biomarker or a new cancer therapeutic target.
- Published
- 2020
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