1. Management of relapsed multiple myeloma:Recommendations of the international myeloma working group
- Author
-
Anuj Mahindra, Philippe Moreau, C. S. Chim, Brian G.M. Durie, Gösta Gahrton, J. Hou, Peter O'Gorman, W. J. Chng, KC Anderson, Elena Zamagni, Jo Caers, Xavier Leleu, Hans Erik Johnsen, Peter M. Voorhees, Antonio Palumbo, Jacob P. Laubach, Paul G. Richardson, Shaji Kumar, Artur Jurczyszyn, Sigurdur Y. Kristinsson, Murielle Roussel, P.L. McCarthy, H. Einsele, E. Terpos, Amitabha Mazumder, Tony Reiman, U. H. Mellqvist, Linda M. Pilarski, Robert Z. Orlowski, Jan Westin, Laurent Garderet, Matthew Streetly, Douglas E. Joshua, J. S. Miguel, M.A. Dimopoulos, Heinz Ludwig, Jiachuan Lu, Vincent Rajkumar, Ingemar Turesson, O. Sezer, Laubach, J, Garderet, L., Mahindra, A., Gahrton, G., Caers, J., Sezer, O., Voorhees, P., Leleu, X., Johnsen, H. E., Streetly, M., Jurczyszyn, A., Ludwig, H., Mellqvist, U. H., Chng, W. J., Pilarski, L., Einsele, H., Hou, J., Turesson, I., Zamagni, Elena, Chim, C. S., Mazumder, A., Westin, J., Lu, Jiachuan, Reiman, T., Kristinsson, S., Joshua, D., Roussel, M., O'Gorman, P., Terpos, E., Mccarthy, P., Dimopoulos, M., Moreau, Philippe, Orlowski, R. Z., Miguel, J. S., Anderson, K. C., Palumbo, A., Kumar, S., Rajkumar, V., Durie, B., and Richardson, P. G.
- Subjects
medicine.medical_specialty ,Cancer Research ,medicine.medical_treatment ,Salvage therapy ,Antineoplastic Agents ,Hematopoietic stem cell transplantation ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Internal medicine ,Humans ,Medicine ,Disease management (health) ,Intensive care medicine ,Multiple myeloma ,Salvage Therapy ,Hematology ,business.industry ,Hematopoietic Stem Cell Transplantation ,Disease Management ,medicine.disease ,Surgery ,Clinical trial ,Transplantation ,Clinical research ,Anesthesiology and Pain Medicine ,Oncology ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,Multiple Myeloma ,business ,030215 immunology - Abstract
The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM.Leukemia accepted article preview online, 29 December 2015. doi:10.1038/leu.2015.356.
- Published
- 2016
- Full Text
- View/download PDF