1. Correction to: Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update
- Author
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Abhijit Chowdhury, Pratibha Kale, Cosmas Rinaldi A Lesmana, Vikrant Sood, Eileen L Yoon, Dharmesh Kapoor, Qin Ning, Cyriac Abby Philips, Ashok Choudhury, Samir Shah, Neeraj Saraf, Barjesh Chander Sharma, Rino Alvani Gani, Subash Gupta, Archana Rastogi, P N Rao, Madunil A. Niriella, Hai Li, Kemal Fariz Kalista, Vinod Arora, Shalimar, Chundamannil E. Eapen, Chetan Kalal, Dong Joon Kim, Hasmik Ghazinyan, Guresh Kumar, Vandana Midha, B. R. Thapa, Anil Arora, Ajit Sood, Anshu Srivastava, Khin Maung Win, Ke Ma, Edward Gane, Wasim Jafri, Ajay Duseja, Ashok Kumar, Harshad Devarbhavi, Sudhir Maharashi, Zeeshan Ahmad Wani, Madhumita Premkumar, V Rajan, Xiaolong Qi, Virender Singh, Mamun Al Mahtab, Gamal Shiha, Akash Shukla, Rajeev Khanna, Diana A. Payawal, Laurentius A. Lesmana, Vivek Vij, Amna Subhan Butt, Samba Siva Rao Pasupuleti, Sanjiv Saigal, Kaushal Madan, Jinhua Hu, Hitendra Garg, Guan H Lee, G Carpio, Viniyendra Pamecha, Mohd Rela, Do Seon Song, Amit Rastogi, R. K. Dhiman, Surender Kumar Yachha, A Olithselvan, Chhagan Bihari Sharma, Atsushi Tanaka, Anoop Saraya, Omesh Goyal, Rajan P Mathur, Jose D. Sollano, Man-Fung Yuen, Zaigham Abbas, A. Kadir Dokmeci, Zhongping Duan, Jin Mo Yang, Yogesh Chawla, Ashish Goel, Shahinul Alam, Rakhi Maiwall, Manoj K Sharma, Lovkesh Anand, Manav Wadhawan, Fazal Karim, Soek Siam Tan, Puja Sakhuja, Vivek A. Saraswat, Osamu Yokosuka, Vishal Garg, Ankur Jindal, Tanmay Vyas, Tao Chen, Sunil Taneja, Seema Alam, Dominic Ray Chaudhuri, Priyanka Jain, Bikrant Bihari Lal, Salimur Rahman, Satoshi Mochida, Meenu Bajpai, Seng Gee Lim, Ananta Shresta, Manoj Sahu, Sombat Treeprasertsuk, Chen Yu, Shiv Kumar Sarin, V G Mohan Prasad, Arvinder S. Soin, Wei Ting Chen, G K Lau, and Saeed Hamid
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medicine.medical_specialty ,MEDLINE ,Internet portal ,Jaundice ,Decompensation ,Guidelines ,Acute decompensation ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Acute on chronic liver failure ,Hepatology ,business.industry ,Chronic liver disease ,Liver failure ,Correction ,AARC ,Alcoholic liver disease ,Colorectal surgery ,Cirrhosis ,030220 oncology & carcinogenesis ,ALF ,030211 gastroenterology & hepatology ,business - Abstract
The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. With international groups volunteering to join, the “APASL ACLF Research Consortium (AARC)” was formed in 2012, which continued to collect prospective ACLF patient data. Based on the prospective data analysis of nearly 1400 patients, the AARC consensus was published in 2014. In the past nearly four-and-a-half years, the AARC database has been enriched to about 5200 cases by major hepatology centers across Asia. The data published during the interim period were carefully analyzed and areas of contention and new developments in the field of ACLF were prioritized in a systematic manner. The AARC database was also approached for answering some of the issues where published data were limited, such as liver failure grading, its impact on the ‘Golden Therapeutic Window’, extrahepatic organ dysfunction and failure, development of sepsis, distinctive features of acute decompensation from ACLF and pediatric ACLF and the issues were analyzed. These initiatives concluded in a two-day meeting in October 2018 at New Delhi with finalization of the new AARC consensus. Only those statements, which were based on evidence using the Grade System and were unanimously recommended, were accepted. Finalized statements were again circulated to all the experts and subsequently presented at the AARC investigators meeting at the AASLD in November 2018. The suggestions from the experts were used to revise and finalize the consensus. After detailed deliberations and data analysis, the original definition of ACLF was found to withstand the test of time and be able to identify a homogenous group of patients presenting with liver failure. New management options including the algorithms for the management of coagulation disorders, renal replacement therapy, sepsis, variceal bleed, antivirals and criteria for liver transplantation for ACLF patients were proposed. The final consensus statements along with the relevant background information and areas requiring future studies are presented here., Article Highlights Updated on the basis of AARC data of >3300 cases enrolled into AARC registry prospectivelyACLF is distinct form Acute Decompensation of cirrhosisNewer sections on DILI-ACLF, AIH-ACLF, PVT/HVOTO–ACLFReversibility of Chronic Liver Disease in ACLFPortal and systemic hemodynamics and their relevance in ACLFAcute Portal Hypertension and Variceal progression in ACLFAARC score as a guide for treatment strategies in ACLFACLF in Children-first consensus on pediatric ACLF
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- 2019