1. In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma
- Author
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Qing Ye, Xiaoyan Wang, Xianzeng Zhang, Jing Li, Zheng Huang, Jun Lin, Zhengzhen Sun, Shusen Xie, and Yuting Huo
- Subjects
0301 basic medicine ,Carcinoma nasofaríngeo ,Cripto ,Metastasis ,Viral Matrix Proteins ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Nasopharyngeal carcinoma ,otorhinolaryngologic diseases ,Humans ,Medicine ,In vitro study ,LMP1 ,Nasopharyngeal Carcinoma ,business.industry ,Nasopharyngitis ,Nasopharyngeal Neoplasms ,Diagnostic marker ,Metástase ,medicine.disease ,lcsh:Otorhinolaryngology ,Cripto-1 ,lcsh:RF1-547 ,stomatognathic diseases ,030104 developmental biology ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Cancer research ,Intercellular Signaling Peptides and Proteins ,Treatment strategy ,business ,hormones, hormone substitutes, and hormone antagonists ,Bacterial Outer Membrane Proteins - Abstract
Introduction: Nasopharyngeal carcinoma, an epithelial-derived malignant tumor which because of its anatomical location and atypical early symptoms, when diagnosed invasion and metastasis often have occurred. This requires a better understanding of the development mechanism, identifying diagnostic markers, and developing new treatment strategies. Objective: To study the relationship of LMP1 and Cripto-1 in nasopharyngeal carcinoma. Methods: The expression of LMP1 and Cripto-1 in specimens obtained from nasopharyngeal carcinoma patients (n = 42) and nasopharyngitis patients (n = 22) were examined. The expression of LMP1 and Cripto-1 in LMP1-negative and LMP1-positive (CNE1-LMP1) cells were also examined. Results: The expression of LMP1 and Cripto-1 was significantly higher in nasopharyngeal carcinoma than in nasopharyngitis (p
- Published
- 2020