1. Ocular toxoplasmosis: phenotype differences between toxoplasma IgM positive and IgM negative patients in a large cohort
- Author
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Joshua Luis, Carlos Pavesio, Benedict Girling, Rabia Bourkiza, Catherine Cosgrove, Angela Rees, Sofia Ajamil-Rodanes, and Mark Westcott
- Subjects
Adult ,Male ,medicine.medical_specialty ,Igm antibody ,Patient demographics ,030231 tropical medicine ,Antiprotozoal Agents ,Visual Acuity ,Antibodies, Protozoan ,Enzyme-Linked Immunosorbent Assay ,Intraocular inflammation ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Young Adult ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Eye Infections, Parasitic ,Macular involvement ,Toxoplasmosis, Ocular ,Aged ,Retrospective Studies ,business.industry ,Middle Aged ,medicine.disease ,Phenotype ,Sensory Systems ,Toxoplasmosis ,Large cohort ,Ophthalmology ,Immunoglobulin M ,Immunoglobulin G ,030221 ophthalmology & optometry ,Case note ,Female ,business ,Toxoplasma - Abstract
PurposeTo investigate the differences in demographics and clinical characteristics of patients diagnosed with ocular toxoplasmosis according to their IgM status.MethodsRetrospective case note analysis was carried out on patients who tested positive for serum Toxoplasma gondii-specific IgM antibodies (IgM+) as well as a comparator group who tested negative for serum IgM (IgM-), but positive for serum IgG. Patient demographics and clinical features were compared between the two groups to evaluate for any significant differences.ResultsOne hundred and six patients were included in the study between March 2011 and June 2018, consisting of 37 in the IgM +group and 69 in the IgM- group. Patients in the IgM +group were significantly older (51.1 vs 34.1 years, pConclusionsThis study demonstrated significant differences in clinical characteristics of ocular toxoplasmosis according to serum IgM status. IgM+ patients were older, less likely to report pain, had lower levels of intraocular inflammation, but were more likely to have macular involvement. We also found age to be correlated with larger and more peripheral lesions.
- Published
- 2019