1. Imported cysticercosis in Spain: A retrospective case series from the +REDIVI Collaborative Network
- Author
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Herrador, Zaida, Perez-Molina, Jose A., Henriquez Camacho, Cesar Augusto, Rodriguez-Guardado, Azucena, Bosch-Nicolau, Pau, Calabuig, Eva, Dominguez-Castellano, Angel, Asuncion Perez-Jacoiste, Maria, Ladron de Guevara, M. Concepcion, Mena, Ana, Manuel Ruiz-Giardin, Jose, Torrus, Diego, Wikman-Jorgensen, Philip, Benito, Agustin, Lopez-Velez, Rogelio, Aguilera, Paloma, Martinez Serrano, Maria, Garcia Rodriguez, Magdalena, Diaz Menendez, Marta, Meije, Yolanda, Martinez-Montauti, Joaquim, Sanz, Xavier, Pacheco Tenza, Isabel, Gonzalez Cuello, Inmaculada, Martinez Lopez, Belen, Llenas-Garcia, Jara, Masia, Mar, Padilla, Sergio, Romero, Monica, Ramos Rincon, Jose Manuel, Suarez, Ines, Perez-Ayala, Ana, Maria Herrero, Juan, Lizasoain, Manuel, Rojo, Pablo, Matarranz, Mariano, Zarco, Carlos, Fernandez Suarez, Jonathan, Boga Ribeiro, Jose Antonio, Goikoetxea Aguirre, Josune, Zubero Sulibarria, Miren Zurine, Sanmartin Lopez, Juan Victor, Velasco Arribas, Maria, Penaranda Vera, Maria, Molina, Israel, Sanchez Montalva, Adrian, Salvador, Fernando, Monge-Maillo, Begona, Norman, Francesca, Chamorro Tojeiro, Sandra, Trevino-Maruri, Begoria, Serre Delcor, Nuria, Soriano-Arandes, Antonio, Pou Ciruelo, Diana, Bocanegra, Cristina, REDIVI Study Grp, Instituto de Salud Carlos III, European Regional Development Fund, Instituto de Salud Carlos III - ISCIII, and European Regional Development Fund (ERDF/FEDER)
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pediatrics ,030231 tropical medicine ,Neurocysticercosis ,Disease ,Albendazole ,Serology ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,parasitic diseases ,Taenia solium ,medicine ,Travel medicine ,Humans ,030212 general & internal medicine ,Retrospective Studies ,business.industry ,Cysticercosis ,Public Health, Environmental and Occupational Health ,Neglected Diseases ,medicine.disease ,Europe ,medicine.drug_formulation_ingredient ,Neglected diseases ,Infectious Diseases ,Spain ,business ,Imported infectious diseases ,Travel Medicine ,medicine.drug - Abstract
Background: Neurocysticercosis (NCC) is the most common parasitic neurological disease worldwide and a major cause of epilepsy. Spain is the country reporting the highest number of NCC imported cases in Europe. Methodology: Retrospective case series of NCC patients registered in the +REDIVI Network from October 1, 2009 to July 2018. A specific questionnaire, including clinical and diagnostic characteristics, was created and sent to the collaborator centers. Results: 46 cases were included in the analysis. 55% were male, mean age of 40 years. 95.6% were migrants. The median duration since migration from an endemic area was 10 years. Predominant nationalities were Ecuadorians (50%) and Bolivians (30.4%). Frequent locations were parenchymal (87%), subarachnoid (26.1%) and intraventricular cysts (10.9%). Serological analysis was performed in 91.3%, being 54.8% positive. Most prevalent clinical manifestations were persistent headache (60.9%), epilepsy (43.5%) and visual changes (13%). Patients were mainly treated with albendazole (76.1%), corticosteroids (67.4%), and anticonvulsionants (52.2%). 82.5% had a favorable clinical outcome. Conclusions: Most NCC cases were long-standing migrants. Few clinical differences were observed depending on the cysticerci location. The treatment was often not according to current recommendations, and no uniform criteria were followed when it came to the therapeutic regimen. NCC case management in Spain (including clinician awareness and laboratory capacity improvements) needs to be strengthened., We would thanks Maria Jesus Perteguer from the National Center of Microbiology for the information and update on NCC lab techniques currently performed in Spain. The corresponding author's affiliation centre belongs to the ISCIII-Sub. Gral. Redes-Network Biomedical Research on Tropical Diseases (RICET in Spanish) grant RD16CIII/0003/0001, RD16/0027/0020, RD16CIII/0003/0001 and the European Regional Development Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- Published
- 2020