1. Intracerebral dynamics of saccade generation in the human frontal eye field and supplementary eye field
- Author
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Philippe Kahane, Jean-Philippe Lachaux, Dominique Hoffmann, Alain Berthoz, Lorella Minotti, Deransart, Colin, Biologie et pathologie digestive, Institut Louis Bugnard-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurosciences cognitives et imagerie cérébrale (NCIC), Centre National de la Recherche Scientifique (CNRS), Neurosciences précliniques, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neurologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Laboratoire de Physiologie de la Perception et de l'Action (LPPA), Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), and Collaboration
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Supplementary eye field ,genetic structures ,MESH: Frontal Lobe ,Electroencephalography ,MESH: Signal Processing, Computer-Assisted ,0302 clinical medicine ,Oculomotor Nerve ,Neural Pathways ,Evoked Potentials ,MESH: Brain Mapping ,Cerebral Cortex ,Brain Mapping ,0303 health sciences ,Fourier Analysis ,medicine.diagnostic_test ,MESH: Electric Stimulation ,Signal Processing, Computer-Assisted ,Time resolution ,Electrodes, Implanted ,Frontal Lobe ,MESH: Evoked Potentials ,Neurology ,Saccade ,Visual Perception ,MESH: Saccades ,Psychology ,Cognitive Neuroscience ,MESH: Orientation ,03 medical and health sciences ,Orientation ,MESH: Electroencephalography ,Reaction Time ,Saccades ,medicine ,Humans ,Dominance, Cerebral ,030304 developmental biology ,MESH: Oculomotor Nerve ,MESH: Humans ,MESH: Visual Perception ,MESH: Neural Pathways ,Eye movement ,MESH: Dominance, Cerebral ,Electric Stimulation ,Saccadic masking ,MESH: Cerebral Cortex ,MESH: Reaction Time ,Functional imaging ,MESH: Epilepsies, Partial ,Temporal resolution ,MESH: Electrodes, Implanted ,Epilepsies, Partial ,Neuroscience ,030217 neurology & neurosurgery ,MESH: Fourier Analysis - Abstract
International audience; Recent functional imaging and electrical stimulation studies have localized in humans two frontal regions critical for the production of saccadic and anti-saccadic eye movements: the frontal and supplementary eye fields (FEF and SEF, respectively). We investigated the time course of their activations during the generation of pro- and anti-saccades from direct intracranial EEG recordings of three human epileptic patients. We found the preparation and the production of the saccades to be coincident with focal and transient increases of EEG power above 60 Hz. Those were produced in very specific brain sites distributed in the FEF and the SEF (as identified by previous human studies at a coarser time resolution). Furthermore, the spatio-temporal resolution of those recordings turned out to be sufficient to discriminate anatomically between several types of neural responses, determined either by the visual or by the motor components of the saccade tasks, and within this second category of responses, between some associated with the preparation of the saccades and others associated with their execution. Altogether, this study provides the first evidence of high-frequency neural responses in the generation of saccades in humans, and provides a firm basis for other studies detailing further the functional organization of the human oculomotor system at this level of spatial and temporal resolution.
- Published
- 2006
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