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In the context of changing climatic scenario, depletion of natural resources and increasing hunger and malnutrition, it is necessary to ensure sustainable agricultural production and resource utilization. Bio-stimulants are a viable alternative in this condition. Bio-stimulant consists of various substances and microorganisms which have found to be effective in enhancing plant growth enhance nutrition efficiency, abiotic stress tolerance and crop quality traits. Vegetables are a rich and relatively cheaper source of vitamins. Consumption of vegetable provides palatability and taste, increases appetite, supplies fibre for digestion and helps in preventing malnutrition. To enhance the sustainability of vegetable production, bio-stimulants can be effectively used. In this chapter, status of vegetable production worldwide and in India, categories of plant bio-stimulants and its importance in vegetable production enhancement and factors contributing towards the expansion of the bio-stimulants market in the world have been discussed. The impact of PGPR carrying plentiful multifunctional plant growth-promoting activities on vegetable crops is discussed. Furthermore, this chapter has summarized recent advancement in bio-stimulant commercial products and vegetable disease interaction and has drawn lines of future research that can aid to improve the effectiveness of the use of bio-stimulants in sustainable quality vegetable production.