1. Weighted single‐step genome‐wide association study and pathway analyses for feed efficiency traits in Nellore cattle
- Author
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Nedenia Bonvino Stafuzza, Fernando B. Lopes, Marcos Fernando Oliveira e Costa, Cláudio de Ulhôa Magnabosco, Rafael Espigolan, Ludmilla C. Brunes, Raysildo Barbosa Lôbo, Fernando Baldi, Universidade Federal de Goiás (UFG), Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA), Universidade Estadual Paulista (Unesp), Inc., National Association of Breeders and Researchers (ANCP), Universidade de São Paulo (USP), and Animal Science Institute
- Subjects
0301 basic medicine ,Candidate gene ,Bos indicus ,residual body weight gain ,Biology ,Polymorphism, Single Nucleotide ,Bitter taste receptor activity ,Feed conversion ratio ,Eating ,03 medical and health sciences ,Food Animals ,Neuropeptide hormone activity ,Animals ,Gene ,Genetics ,Genome ,Leptin ,weighted single-step ,0402 animal and dairy science ,Wnt signaling pathway ,04 agricultural and veterinary sciences ,General Medicine ,Animal Feed ,040201 dairy & animal science ,Phenotype ,030104 developmental biology ,residual feed intake ,GBLUP ,Cattle ,Animal Science and Zoology ,Residual feed intake ,Genome-Wide Association Study - Abstract
Made available in DSpace on 2020-12-12T01:30:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient absorption. Enrichment analysis revealed functional pathways (p-value
- Published
- 2020