1. Ivermectin treatment in lactating mares results in suboptimal ivermectin exposure in their suckling foals
- Author
-
Amandine Gesbert, Fabrice Reigner, Jean-François Sutra, Ghismon-de-Kasin Mayinda, Anne Lespine, Delphine Serreau, Guillaume Sallé, Infectiologie et Santé Publique (UMR ISP), Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Innovations Thérapeutiques et Résistances (InTheRes), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), INRAE, Région Normandie (PAMIEBO project) stipend, Institut Français du Cheval et de l’Equitation grant (CYATHOMIX project), and Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
- Subjects
040301 veterinary sciences ,animal diseases ,[SDV]Life Sciences [q-bio] ,Drug Resistance ,Physiology ,Drug resistance ,Egg count ,Horse ,0403 veterinary science ,03 medical and health sciences ,Ivermectin ,biology.animal ,parasitic diseases ,medicine ,Animals ,Lactation ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,Horses ,Parasite Egg Count ,030304 developmental biology ,Nematode ,0303 health sciences ,[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health ,General Veterinary ,biology ,Strongyle ,04 agricultural and veterinary sciences ,General Medicine ,Foal ,3. Good health ,Parasitology ,Female ,Horse Diseases ,medicine.drug - Abstract
International audience; The management of equine strongyles has become problematic over the last decade because of an increased prevalence of drug-resistant isolates worldwide. Therapeutic options are therefore limited, leaving macrocyclic lactones as the most often effective drug class. However, their lipophilic properties result in a long-lasting elimination that could favour drug resistance selection. As a result, ivermectin treatment in lactating mares could promote suboptimal exposure of their foal parasites to ivermectin, thereby selecting for more resistant worms. To test for this putative transfer, we selected two groups of six foal-mare pairs, one group of mares receiving ivermectin and the other being left untreated. We compared faecal egg count trajectories in foals from the two groups and quantified plasma ivermectin concentrations in ivermectin treated mares and their foals during seven days. Our results showed limited but sustained plasmatic exposure of foals associated with non-significant faecal egg count reduction (P = 0.69). This suggests that ivermectin treatment in lactating mares results in suboptimal exposure to the drug in their foal.
- Published
- 2021