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This research focuses on the Neolithic populations of Western Switzerland (5500–2200 BCE) and on establishing their paleopathological profile. This chronological period presents varying burial practices, and the aim was to be able to synthesise all information regarding the pathologies these populations exhibited, in such a way that statistical tests could be performed to determine whether geographical (site location), biological (age, sex, stature) and chronological factors played a role in lesion distribution. As a result, a methodology was devised to consider bone lesions in both a quantified and qualified manner, and able to handle individualised, multiple and commingled remains. The statistical analysis showed that pathological profiles differed depending on site location, with some exhibiting patterns that raise further questions as to the socio-economical functioning of these prehistoric societies. Biological factors also appear to play a role in lesion distribution, with immature individuals exhibiting more metabolic deregulations, whilst the adults—as expected—showed more signs of degenerative pathologies. Some chronological evolution of health is also perceivable; however, the small sample size available for some periods means these results are tentative at best. These remains, however, proved more than an accumulation of bone lesions, and the qualified data collected from them also yielded individual and collective narratives of health. Instances of infectious diseases were discovered, indicating that pathologies such as tuberculosis were a persistent presence at the time, with all the consequences this entails.

We present the case of an individual from the Simon Identified Skeletal Collection (Vaud, Switzerland) who appears to have been affected by a form of neoplastic disease. A detailed description and differential diagnosis of the lesions was conducted and is presented here. Considering the biological profile of the individual, the distribution of the lesions, and their appearance, a case is made for multiple myeloma as the most likely diagnosis. This case study demonstrates the importance of adopting a detailed approach for recording the metric and non-metric traits of lesions, using multiple methods of analysis, and providing graphic and photographic documentation in order to provide valuable comparison material through publication. The good preservation of the remains and the background information available for the individual also make this case ideal for inclusion in future comparative studies.