Search

A new copper‐catalyzed sp3‐carbon radical/halogen radical cross‐coupling strategy for the formation of C(sp3)‐X bond is described. This provides a general method for synthesis of α‐halogenated and α,α‐dihalogenated‐1,3‐dicarbonyl compounds using sodium halides as halogen source under mild conditions. [ABSTRACT FROM AUTHOR]

A novel copper-catalyzed sp3-carbon radical/carbamoyl radical cross-coupling protocol for the construction of C(sp3)-C(O) bond is described. This provides a straightforward method for synthesis of 2-carbamoyl-1,3-dicarbonyl compounds in good to excellent yields under mild conditions. Mechanistic studies confirms the generation of both carbamoyl and C(sp3)-centered radicals directly from oxidation of C(sp3)-H bond of formamides and 1,3-dicarbonyl compounds, respectively. Image 1 • The reaction of 1,3-dicarbonyl compounds and formamides afforded the 2-carbamoyl-1,3-dicarbonyl compounds. • This protocol provided an efficient construction of C(sp3)−C(O) bond strategy. • Mechanistic studies confirm that the products were formed through radical-radical cross-coupling process. [ABSTRACT FROM AUTHOR]