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The Austrian emperor and the Croat-Hungarian king Franz Joseph I (1830/1848-1916) was the longest-serving ruler of the Habsburg dynasty. Among his properties was Osijek, which since 1809 enjoyed the status of a free royal city. In the period under review, it was the seat of the Virovitica County and the capital of the Kingdom of Slavonia until its incorporation into the Triune Kingdom of Croatia, Slavonia and Dalmatia after the Croat-Hungarian settlement of 1868. Because of this, Osijek was not only a political, economic and cultural centre but also a health care centre. At the beginning of the reign of Franz Joseph I, two hospitals were operating in it: a military one in the baroque military garrison Tvrđa and a civilian one in New Town. The most significant role in the further development of the Osijek and Slavonian health care was played by the trust established in 1806 from the legacies of innkeeper Johann Kolhoffer, tanner Josef Huttler and Jesuit Cristian Monsperger. Although originally intended for the establishment of an orphanage, due to a number of unfavourable political circumstances, the trust, until then with multiple interests attributed to the principal, came under the administration of the city of Osijek only in 1867. Along with the new orphanage opened in 1874, a new hospital was completed as well in 1868, also with the money from the trust. Huttler-Kohlhoffer-Monsperger Foundation Hospital was the largest and most modern hospital in the Triune Kingdom, and despite later constructions of various hospital wards, its building has remained the most representative building within the Clinical-Hospital Centre Osijek. [ABSTRACT FROM AUTHOR]

Although stethoscope was invented by French physician René-Théophile-Hyacinthe Laennec (1781-1826) in 1816, its wider clinical application started only after the publication of his book entitled De l'Auscultation Médiate ou Traité, du Diagnostic des Maladies des Poumons et du Coeur in 1819. Its invention coincided with the development of the 'hospital medicine' in the post-revolutionary Paris during the first quarter of the 19th century. It has enabled then contemporary physicians to explain the correlation between the patient symptoms and the clinical findings and thus has helped the shift from the humoral pathology towards the solitary pathology. [ABSTRACT FROM AUTHOR]

Emanuel Edward Klein (Osijek, 1844 - Hove, 1925) was a British microbiologist of Croatian origin. He completed his medical studies in Vienna in 1869. In 1869 he was sent to England to determine terms for the translation of Samuel Stricker's manual Handbuch von den Geweben des Menchen und der Tiere. During his visit he made a good impression on John Burdon Sanderson and John Simon, which was the main reason why he was invited to London in 1871 to conduct investigations under their guidance. In 1873 Klein began his collaboration with the Saint Bartholomew's Hospital, where he was appointed as a Joint Professor of General Anatomy and Physiology. His researches were in the fields of anatomy, histology, pathology, embryology, physiology, and especially microbiology. He did a great deal to its development in Britain. He has written about 260 scientific papers on a broad range of different topics. Despite all the aforementioned facts, his work was never properly studied, and he is almost unknown outside academic circles. For that reason, attitudes towards him still range between the extremes of calling him the father of British microbiology on one side, and attributing him as a diligent and industrious plodder on the other. In this paper we will try to prove the first attitude. We will put his researches in a general context. Finally we will highlight his original achievements in the isolation of new microbes. [ABSTRACT FROM AUTHOR]