1. Cortical thickness and sulcal depth: insights on development and psychopathology in paediatric epilepsy
- Author
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Rochelle Caplan, Duygu Tosun, Jennifer G. Levitt, and Prabha Siddarth
- Subjects
0301 basic medicine ,Paper ,medicine.medical_specialty ,Clinical Sciences ,Neurodegenerative ,03 medical and health sciences ,Epilepsy ,Typically developing ,0302 clinical medicine ,Clinical Research ,Paediatric epilepsy ,medicine ,2.1 Biological and endogenous factors ,Aetiology ,Psychiatry ,Prolonged seizures ,medicine.diagnostic_test ,Neurosciences ,Magnetic resonance imaging ,Creative commons ,medicine.disease ,Brain Disorders ,Psychiatry and Mental health ,Mental Health ,030104 developmental biology ,Neurological ,Psychiatric diagnosis ,Public Health and Health Services ,Psychology ,030217 neurology & neurosurgery ,Psychopathology - Abstract
BackgroundThe relationship between cortical thickness (CThick) and sulcal depth (SDepth) changes across brain regions during development. Epilepsy youth have CThick and SDepth abnormalities and prevalent psychiatric disorders.AimsThis study compared the CThick–SDepth relationship in children with focal epilepsy with typically developing children (TDC) and the role played by seizure and psychopathology variables.MethodA surface-based, computational high-resolution three-dimesional (3D) magnetic resonance image analytic technique compared regional CThick–SDepth relationships in 42 participants with focal epilepsy and 46 TDC (6–16 years) imaged in a 1.5 Tesla scanner. Psychiatric interviews administered to each participant yielded psychiatric diagnoses. Parents provided seizure-related information.ResultsThe TDC group alone demonstrated a significant negative medial fronto-orbital CThick–SDepth correlation. Focal epilepsy participants with but not without psychiatric diagnoses showed significant positive pre-central and post-central CThick–SDepth associations not found in TDC. Although the history of prolonged seizures was significantly associated with the postcentral CThick–SDepth correlation, it was unrelated to the presence/absence of psychiatric diagnoses.ConclusionsAbnormal CThick–SDepth pre-central and post-central associations might be a psychopathology biomarker in paediatric focal epilepsy.
- Published
- 2015