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Highlights from the article: B Background: b Neuro-developmental disorders (NDDs) are common but severe pediatric diseases affecting a child's brain development and growth. Early intervention significantly improves patient's neuropsychological function, and early diagnosis is the key step for early intervention. Meanwhile, the genetic variants contributing to pediatric NDDs are complex including copy number variant (CNV) or single nucleotide variant (SNV), balanced or imbalanced chromosomal rearrangement, gene-disruption rearrangement or noncoding-region rearrangement, somatic/mosaic or germline variant.