1. Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis
- Author
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Lanling Wang, Yuhuan Song, Chunlei Zhang, and Zhennan Zhang
- Subjects
Vitamin ,medicine.medical_specialty ,endocrine system diseases ,vitamin D ,Gastroenterology ,vitamin D deficiency ,Systematic review/Meta-analysis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Vitamin D and neurology ,030212 general & internal medicine ,Serum vitamin ,25(OH)D ,business.industry ,Healthy subjects ,nutritional and metabolic diseases ,General Medicine ,Publication bias ,medicine.disease ,gestational diabetes mellitus ,meta-analysis ,Gestational diabetes ,chemistry ,Meta-analysis ,business - Abstract
Introduction This meta-analysis was performed to confirm the relationship of gestational diabetes mellitus (GDM) and vitamin D. Material and methods PubMed and CNKI databases were searched for relevant articles. Standard mean difference (SMD) along with 95% CI was used to compare vitamin D level between women with GDM and healthy subjects. The correlation coefficient between the vitamin D and homeostasis model assessment-insulin resistance index (HOMA-IR) was analyzed. Results The vitamin D level of GDM subjects was much lower than healthy subjects (SMD = -0.71, 95% CI: -0.91, -0.50). Vitamin D deficiency was associated with high risk of GDM (OR = 1.15, 95% CI: 1.07-1.23). Vitamin D was negatively correlated with HOMA-IR (r = -0.62, 95% CI: -0.85, -0.39). The analysis showed no publication bias (Egger's: p = 0.197; Begg's: p = 0.786). Conclusions Vitamin D is closely associated with the onset of GDM.
- Published
- 2020