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1. Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors

Author

Zhou, Yuefen, Chow, Chun, Murphy, Douglas E., Sun, Zhongxiang, Bertolini, Thomas, Froelich, Jamie M., Webber, Stephen E., Hermann, Thomas, and Wall, Daniel

Subjects
*ANTIBACTERIAL agents, *PIPERIDINE, *AMINOGLYCOSIDES, *PSEUDOMONAS aeruginosa
Abstract

Abstract: Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa. [Copyright &y& Elsevier]

Published
2008
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