1. Dairy consumption, systolic blood pressure, and risk of hypertension : Mendelian randomization study
- Author
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Ding, Ming, Huang, Tao, Bergholdt, Helle K. M., Nordestgaard, Borge G., Ellervik, Christina, Qi, Lu, Frazier-Wood, Alexis C., Aslibekyan, Stella, North, Kari E., Voortman, Trudy, Graff, Mariaelisa, Smith, Caren E., Lai, Chao-Qiang, Varbo, Anette, Lemaitre, Rozenn N., de Jonge, Ester A. L., Fumeron, Frederic, Corella, Dolores, Wang, Carol A., Tjonneland, Anne, Overvad, Kim, Sorensen, Thorkild I. A., Feitosa, Mary F., Wojczynski, Mary K., Kahonen, Mika, Ahmad, Shafqat, Renström, Frida, Psaty, Bruce M., Siscovick, David S., Barroso, Ines, Johansson, Ingegerd, Hernandez, Dena, Ferrucci, Luigi, Bandinelli, Stefania, Linneberg, Allan, Sandholt, Camilla Helene, Pedersen, Oluf, Hansen, Torben, Schulz, Christina-Alexandra, Sonestedt, Emily, Orho-Melander, Marju, Chen, Tzu-An, Rotter, Jerome I., Allison, Mathew A., Rich, Stephen S., Sorli, Jose V., Coltell, Oscar, Pennell, Craig E., Eastwood, Peter R., Hofman, Albert, Uitterlinden, Andre G., Zillikens, MCarola, van Rooij, Frank J. A., Chu, Audrey Y., Rose, Lynda M., Ridker, Paul M., Viikari, Jorma, Raitakari, Olli, Lehtimaki, Terho, Mikkila, Vera, Willett, Walter C., Wang, Yujie, Tucker, Katherine L., Ordovas, Jose M., Kilpelainen, Tuomas O., Province, Michael A., Franks, Paul W., Arnett, Donna K., Tanaka, Toshiko, Toft, Ulla, Ericso, Ulrika, Franco, Oscar H., Mozaffarian, Dariush, Hu, Frank B., Chasman, Daniel I., Department of Food and Nutrition, and University of Helsinki
- Subjects
medicine.medical_treatment ,Blood Pressure ,Review ,030204 cardiovascular system & hematology ,Corrections ,law.invention ,0302 clinical medicine ,MILK ,Randomized controlled trial ,law ,GENETIC-VARIANTS ,Cardiac and Cardiovascular Systems ,030212 general & internal medicine ,Prospective cohort study ,METABOLIC SYNDROME ,Lactase ,Randomized Controlled Trials as Topic ,2. Zero hunger ,Kardiologi ,Nutrition and Dietetics ,General Medicine ,16. Peace & justice ,3. Good health ,CONTROLLED-TRIALS ,Näringslära ,Observational Studies as Topic ,BODY-WEIGHT ,CARDIOVASCULAR-DISEASE ,Hypertension ,3143 Nutrition ,medicine.medical_specialty ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Internal medicine ,Mendelian randomization ,medicine ,Journal Article ,Humans ,Genetic Predisposition to Disease ,business.industry ,INCIDENT HYPERTENSION ,Research ,Odds ratio ,ADULTS ,Feeding Behavior ,ta3121 ,Mendelian Randomization Analysis ,Confidence interval ,Surgery ,Lactase persistence ,Blood pressure ,FAT ,3121 General medicine, internal medicine and other clinical medicine ,DOSE-RESPONSE METAANALYSIS ,Dairy Products ,business ,Meta-Analysis - Abstract
Objective To examine whether previous observed inverse associations of dairy intake with systolic blood pressure and risk of hypertension were causal. Design Mendelian randomization study using the single nucleotide polymorphism rs4988235 related to lactase persistence as an instrumental variable. Setting CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium. Participants Data from 22 studies with 171 213 participants, and an additional 10 published prospective studies with 26 119 participants included in the observational analysis. Main outcome measures The instrumental variable estimation was conducted using the ratio of coefficients approach. Using meta-analysis, an additional eight published randomized clinical trials on the association of dairy consumption with systolic blood pressure were summarized. Results Compared with the CC genotype (CC is associated with complete lactase deficiency), the CT/TT genotype (TT is associated with lactose persistence, and CT is associated with certain lactase deficiency) of LCT-13910 (lactase persistence gene) rs4988235 was associated with higher dairy consumption (0.23 (about 55 g/day), 95% confidence interval 0.17 to 0.29) serving/day; P
- Published
- 2017
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