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BACKGROUND: Three-dimensional (3D) printing is an emerging technology in the field of dentistry. It utilizes a layer-by-layer manufacturing technique to create scaffolds suitable for periodontal tissue engineering applications. Tissue scaffolds produced through 3D printing can possess controlled characteristics, including internal structure, porosity, and interconnectivity, making it an ideal strategy for periodontal tissue engineering. OBJECTIVE: To review the applications of 3D printed scaffolds in periodontal regeneration. METHODS: English search terms were “3D printing, periodontal tissue engineering, additive manufacturing, regenerative medicine, bioengineering, scaffold, bioprinting, periodontitis”. Chinese search terms were “3D printing, additive manufacturing, periodontal tissue engineering, scaffolds, bio-inks, bioprinting, tissue engineering”. Relevant literature published from 2000 to 2023 in PubMed and CNKI databases was retrieved and included in the review. RESULTS AND CONCLUSION: Over the past few decades, 3D printing technology has made significant progress and breakthroughs in tissue engineering and biomedical fields. 3D printing technology can provide highly personalized treatment programs, improve the suitability and therapeutic effect of therapeutic stents, and has broad application prospects in periodontal tissue engineering. In periodontal tissue engineering, 3D printing applications can better mimic the complex structures of biological tissues and manufacture biocompatible scaffold materials with suitable mechanical and rheological properties. The layer-bylayer construction of tissue engineering scaffolds through 3D printing not only enables the creation of precise and intricate scaffold models for personalized treatment of periodontal disease but also facilitates the incorporation of complex microstructures and channels within the scaffolds to promote cell growth and tissue regeneration. [ABSTRACT FROM AUTHOR]