4 results on '"Afinjuomo, Franklin"'
Search Results
2. 3D Printing of Thermo-Sensitive Drugs.
- Author
-
Abdella, Sadikalmahdi, Youssef, Souha H., Afinjuomo, Franklin, Song, Yunmei, Fouladian, Paris, Upton, Richard, and Garg, Sanjay
- Subjects
THREE-dimensional printing ,LIGHT sources ,PRINTMAKING ,MELTING points ,STEREOLITHOGRAPHY - Abstract
Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam
® ) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
3. Printing a cure: A tailored solution for localized drug delivery in liver cancer treatment.
- Author
-
Youssef, Souha H., Ganesan, Raja, Amirmostofian, Marzieh, Kim, Sangseo, Polara, Ruhi, Afinjuomo, Franklin, Song, Yunmei, Chereda, Bradley, Singhal, Nimit, Robinson, Nirmal, and Garg, Sanjay
- Subjects
- *
LIVER cancer , *CANCER chemotherapy , *CANCER treatment , *ADJUVANT chemotherapy , *FLUOROURACIL , *ZEIN (Plant protein) , *BILAYER lipid membranes - Abstract
[Display omitted] Adjuvant chemotherapy is highly recommended for liver cancer to enhance survival rates due to its tendency to recur frequently. Localized drug-eluting implants have gained traction as an alternative to overcome the limitations of systemic chemotherapy. This work describes the development of biodegradable 3D printed (3DP) bilayer films loaded with 5-fluorouracil (5FU) and cisplatin (Cis) with different infill percentages where the 5FU layers were 40%, 30%, and 30% and Cis layers were 10%, 15%, and 10% for films A, B, and C, respectively. The relevant characterization tests were performed, and the drug content of films was 0.68, 0.50, and 0.50 mg of 5FU and 0.39, 0.80, and 0.34 mg of Cis for films A, B, and C, respectively. Cis release was affected by the alterations to the film design, where films A, B, and C showed complete release at 12, 14, and 23 days, respectively. However, 5FU was released over 24 h for all films. The films were stable for up to two weeks after storage at 25 °C/65% relative humidity and four weeks at 4 °C where drug content, tensile strength, FTIR, and thermal analysis results demonstrated negligible alterations. The cytotoxicity of the films was assessed by MTS assays using HepG2 cell lines demonstrating up to 81% reduction in cell viability compared to blank films. Moreover, apoptosis was confirmed by Western Blots and the determination of mitochondrial cell potential, highlighting the potential of these films as a promising approach in adjuvant chemotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. 3D Printing of Thermo-Sensitive Drugs
- Author
-
Sadikalmahdi Abdella, Paris Fouladian, Sanjay Garg, Franklin Afinjuomo, Souha H. Youssef, Yunmei Song, Richard N. Upton, Abdella, Sadikalmahdi, Youssef, Souha H, Afinjuomo, Franklin, Song, Yunmei, Fouladian, Paris, Upton, Richard, and Garg, Sanjay
- Subjects
Fabrication ,FDM ,Computer science ,business.industry ,education ,Pharmaceutical Science ,Low melting point ,3D printing ,Review ,law.invention ,thermolabile ,RS1-441 ,Light source ,thermosensitive ,Pharmacy and materia medica ,law ,SSE ,Digital Light Processing ,DLP ,SLA ,Process engineering ,business ,Stereolithography - Abstract
Refereed/Peer-reviewed Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.
- Published
- 2021
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