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Your search keyword '"Bhayani, Harshil"' showing total 1 results
Start Over Author "Bhayani, Harshil" Topic 610 medicine & health
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1. Mitochondrial DNA mutations and respiratory chain dysfunction in idiopathic and connective tissue disease-related lung fibrosis

Author

Jaeger, Veronika K, Lebrecht, Dirk, Nicholson, Andrew G, Wells, Athol, Bhayani, Harshil, Gazdhar, Amiq, Tamm, Michael, Venhoff, Nils, Geiser, Thomas, and Walker, Ulrich A

Subjects
respiratory system, 610 Medicine & health, respiratory tract diseases, 3. Good health
Abstract

Reactive oxygen species (ROS) are implicated in the aetiology of interstitial lung disease (ILD). We investigated the role of large-scale somatically acquired mutations in mitochondrial DNA (mtDNA) and consecutive respiratory chain dysfunction as a trigger of ROS-formation and lung fibrosis. Mitochondria were analysed in lung biopsies from 30 patients with idiopathic or connective tissue disease (CTD)-related ILD and 13 controls. In 17 patients we had paired biopsies from upper and lower lobes. Control samples were taken from lung cancer resections without interstitial fibrosis. Malondialdehyde, a marker of ROS-formation, was elevated in ILD-biopsies (p = 0.044). The activity of the mitochondrial respiratory chain (cytochrome c-oxidase/succinate dehydrogenase [COX/SDH]-ratio) was depressed in ILD (median = 0.10,) compared with controls (0.12, p

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