1. Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model
- Author
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Emrecan, Bilgin, Tulukoglu, E., Bozok, F., Aksun, M., Yagdi, S., Özcan, A.V., and Saçar, M.
- Subjects
Male ,Vasodilator Agents ,animal experiment ,rabbit ,abdominal aorta ,animal tissue ,Random Allocation ,aorta occlusion ,Malondialdehyde ,Animals ,Edema ,Humans ,controlled study ,muscle ischemia ,Iloprost ,gastrocnemius muscle ,Pentoxifylline ,Muscle, Skeletal ,Ischemia-reperfusion injury/drug therapy ,nonhuman ,animal model ,Rabbit skeletal muscle ,malonaldehyde ,article ,Cardiovascular agents ,continuous infusion ,reperfusion injury ,Disease Models, Animal ,female ,Treatment Outcome ,Drug Therapy, Combination ,Rabbits ,Platelet Aggregation Inhibitors - Abstract
BACKGROUND: We investigated the effects of iloprost and pentoxifylline on skeletal muscle ischemia-reperfusion injury in a rabbit model. METHODS: Forty New Zealand white rabbits were grouped into four. In Group 1, iloprost was continuously infused starting half an hour before the reperfusion following a 2-hour ischemia formed by abdominal aortic occlusion, and it was continued during the 4-hour reperfusion period. Group 2 was treated with pentoxifylline, and Group 3 received saline solution. Group 4 was the sham group. Malondialdehyde levels and edema scores in gastrocnemius muscle were evaluated. RESULTS: Edema score was significantly lower in Group 1 when compared with the control group (Group 1 vs Group 3, p=0.040; Group 2 vs Group 3, p=0.145; Group 1 vs Group 2, p=0.580). Malondialdehyde levels of the medicated groups were significantly lower when compared with the control group (Group 1: 60±11 nmol/g tissue, Group 2: 74±11 nmol/g tissue, Group 3: 95±10 nmol/g tissue; Group 1 vs Group 2, p=0.010; Group 1 vs Group 3, p
- Published
- 2008