1. Intralipid therapy for unexplained recurrent miscarriage and implantation failure: Case-series and literature review
- Author
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Lucie Sedille, L. Placais, Kamilla Kolanska, Catherine Johanet, Ludovic Suner, Audrey Rosefort, Olivier Fain, Arsène Mekinian, Yasmine Ben Kraiem, J. Cohen, Emmanuel Mathieu D’Argent, Emile Daraï, Gilles Kayem, J.-M. Antoine, Nathalie Chabbert Buffet, Noémie Abisror, Lise Selleret, Marie Bornes, Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] (I3), CHU Charles Foix [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Gynécologie-obstétrique et médecine de la reproduction - Maternité [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Hématologie et d'Immunologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], CCSD, Accord Elsevier, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Gynécologie-obstétrique et médecine de la reproduction - Maternité [CHU Tenon], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Subjects
Infertility ,Adult ,medicine.medical_specialty ,Abortion, Habitual ,[SDV]Life Sciences [q-bio] ,Miscarriage ,03 medical and health sciences ,0302 clinical medicine ,Implantation failure ,Pregnancy ,Recurrent miscarriage ,Medicine ,Humans ,030212 general & internal medicine ,Fetal loss ,Embryo Implantation ,Phospholipids ,Retrospective Studies ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Retrospective cohort study ,medicine.disease ,University hospital ,3. Good health ,Soybean Oil ,[SDV] Life Sciences [q-bio] ,Reproductive Medicine ,Emulsions ,Female ,business ,Live birth ,Live Birth - Abstract
Introduction In retrospective cohort study of women with unexplained recurrent implantation failure (RIF) and miscarriage (RM), we analyzed the efficacy and safety of intralipid therapy to obtain a live birth. Patients and methods Women with unexplained RM and/or RIF were included from 2015 to 2018 from three French university hospitals. Results Among 187 women treated for unexplained recurrent miscarriages and implantation failures, 26 women with median age of 36 years (29−43) received intralipid therapy. Among these 26 women, 10 women with a median age of 33 years (31−40) had a history of spontaneous recurrent miscarriages, with a median of 5 (4–8) previous miscarriages. Live births occurred in 7 (70 %) pregnancies under intralipids and were significantly more frequent than in women with recurrent miscarriages who did not receive intralipid therapy (n = 20, p = 0.02). Age, number of previous miscarriages, and additional therapies did not significantly differ between the two groups. Among the 26 included women, 16 had a history of recurrent implantation failures, with median age of 37 years (29−43) and median 9.5 (3–19) embryo transfers. Clinical pregnancy occurred in 9 (56 %) women receiving intralipids after embryo transfers under intralipids among which 5 (55 %) resulted in a live birth. Comparing successful pregnancies under intralipids with those with fetal loss, no significant differences have been noted. Conclusion Intralipids could be an effective and safe therapy in women with unexplained recurrent miscarriages and infertility.
- Published
- 2020
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