Search

The diabetes mellitus is a chronic metabolic dysfunction whose incidence has left increasing in the entire world. The antihiperglicemiants are drugs that are used in the patient's metabolic control, it is important for our diabetic patients the obtaining of a drug of this type that contributes to control the levels of glucose in blood in the periods postpandrials. Our work group is developing a derived product of the natural zeolites (FZ) that have named Glicolit; in previous studies it has shown effects on the intestinal absorption of glucose, slowing the absorption and the increments in blood after the periods postpandrials, this drug at the same time allows these fellows to improve the quality of life and to slow the complications characteristic of this illness. To know the effectiveness of the drug, as well as to deep in the action mechanisms and the kinetics of absorption of the same one. 15 rats were studied, at 6 of them they were administered a preparation of labeled glucose with 14C, in you fast (group 1 control), and to other 9 remaining they were administered a preparation that contained labeled glucose more Glicolit (group 2) . We carried out extractions of blood and radio-active counts in the plasm at different times: it was observed differences in the areas under the curves of absorption of the glucose between both groups of rats, the Glicolit showed its capacity like antihiperglicemiant. The reached results allow us to continue working in the study of this possible medication. The results obtained by the method radioisotopic with marked glucose with 14 C also corroborate the results of previous studies. [ABSTRACT FROM AUTHOR]