1. Quercetin Inhibits Proliferation and Drug Resistance in KB/VCR Oral Cancer Cells and Enhances Its Sensitivity to Vincristine.
- Author
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Yuan, Zhaohu, Wang, Huili, Hu, Ziyou, Huang, Yanqing, Yao, Fang, Sun, Shumei, and Wu, Bingyi
- Subjects
FLAVONOIDS ,DNA ,QUERCETIN ,ACADEMIC medical centers ,ANALYSIS of variance ,BIOLOGICAL assay ,CELL culture ,CELL physiology ,DRUG resistance ,FLOW cytometry ,GENE expression ,MOUTH tumors ,NUTRITION ,SERIAL publications ,STATISTICS ,VINCRISTINE ,DATA analysis ,BODY surface area ,IN vitro studies ,PHYSIOLOGY ,THERAPEUTICS - Abstract
Quercetin has been confirmed to possess antihistamine, anti-inflammatory, antiviral, immunomodulatory, and antioxidant properties. Herein, we evaluated their antitumor activity in vitro by using KB/VCR oral cancer cells. We found that quercetin at 25 to 100 μmol/L effectively inhibited the migration and invasion of KB/VCR cells. Quercetin at dose ranging from 25 to 100 μmol/L significantly inhibited the growth of the KB/VCR cells and at 50 μmol/L arrested cells at the G1 phase and decreased the amount of cells in the S and G2 phase. Apoptosis analysis showed that quercetin at 50 or 100 μmol/L induced apoptosis of KB/VCR cells by suppressing expression of Bax and inducing the expression of Caspase-3 and Bcl-2. Furthermore, we also confirmed that quercetin from 25 to 100 μmol/L reversed gene-encoded Pglycoprotein (P-gp)-mediated MDR in KB/VCR cells by inhibiting the expression of P-gp. For combination treatment with vincristin (0.375 μmol/L) and quercetin (50 μmol/L), the proliferation rate significantly decreased and apoptosis rate significantly increased. This study provided evidence that quercetin induced apoptosis and reversed drug resistance in oral tumor cells and may be a potential candidate for other tumors treatment. [ABSTRACT FROM PUBLISHER]
- Published
- 2015
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