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Four new sesqui-lignans, (7 R , 7' R , 7″ S , 8 S , 8′ S , 8″ S )-4′,5″-dihydroxy-3,5,3′,4″-tetramethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo-lignan-7″,9″-diol ( 1 ), (7 R , 7' R , 7″ S , 8 S , 8′ S , 8″ S )-4′,3″-dihydroxy-3,5,3′,5′,4″-pentamethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo-lignan-7″,9″-diol ( 2 ), (7 R , 7' R , 7″ S , 8 S , 8′ S , 8″ S )-3′,4″-dihydroxy-3,5,4′,5″-tetramethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo-lignan-7″,9″-diol ( 3 ) and acanthopanax A ( 7 ) together with three known compounds ( 4 – 6 ) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus . Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 1 – 6 were found to exhibit selective inhibitory activity on DGAT1 with IC 50 values ranging from 61.1 ± 1.3 to 97.7 ± 1.1 μM and compound 7 showed selective inhibition of DGAT2 with IC 50 value 93.2 ± 1.2. [ABSTRACT FROM AUTHOR]