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Your search keyword '"Rastgar, Hossein"' showing total 1 results
Start Over Author "Rastgar, Hossein" Topic acarbose
1 results on '"Rastgar, Hossein"'

1. Design, Synthesis, and Biological Evaluation of New Indole-Acrylamide-1,2,3-Triazole Derivatives as Potential α-Glucosidase Inhibitors.

Author

Sadat-Ebrahimi, Seyed Esmaeil, Babania, Hiva, Mohammadi-Khanaposhtani, Maryam, Asgari, Mohammad Sadegh, Mojtabavi, Somayeh, Faramarzi, Mohammad Ali, Yahya-Meymandi, Azadeh, Zareie, Samaneh, Larijani, Bagher, Biglar, Mahmoud, Rastgar, Hossein, Foroumadi, Alireza, and Mahdavi, Mohammad

Subjects
TOXICITY testing, CHEMICAL reactions, ACARBOSE
Abstract

In this work, new indole-acrylamide-1,2,3-triazole derivatives 9a–j were synthesized via simple and efficient chemical reactions and screened for in vitro anti-α-glucosidase activities. All the synthesized derivatives exhibited excellent α-glucosidase inhibition in the range of IC50 = 65.0 ± 0.8 − 396.3 ± 0.7 µM as compared to the standard inhibitor acarbose (IC50 = 750.0 ± 1.5 µM). Furthermore, kinetic, docking, and toxicity evaluation of the title compounds were also performed. [ABSTRACT FROM AUTHOR]

Published
2022
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