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Your search keyword '"Enzyme Reactivators chemical synthesis"' showing total 2 results
Start Over Descriptor "Enzyme Reactivators chemical synthesis" Topic acetylcholinesterase
2 results on '"Enzyme Reactivators chemical synthesis"'

1. [Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes].

Author

Hagedorn I, Stark I, Schoene K, and Schenkel H

Subjects
Chemical Phenomena, Chemistry, Isomerism, Pralidoxime Compounds chemical synthesis, Acetylcholinesterase metabolism, Enzyme Reactivators chemical synthesis, Pralidoxime Compounds pharmacology
Abstract

Mono-quaternary salts Z have been prepared from pyridine-aldoximes and 1,3-dihalogen compounds. These were used to synthesize asymmetrical bis-quaternary pyridine-oximes with three-membered bridge. The effect of reactivation of phosphorylated AChE by these substances is less than that of obidoxim (Toxogonin).

Published
1978

2. [Structure-activity relationship in reactivators of acetylcholinesterase inhibited by phosphoric esters. XII. Hydroxyiminomethylalkylpyridine iodomethylate].

Author

Arena F, Luraschi E, Grifantini M, Manna F, and Parente G

Subjects
Animals, Drug Evaluation, Preclinical, Eels, Enzyme Reactivators pharmacology, Enzyme Reactivators therapeutic use, Mice, Oximes pharmacology, Oximes therapeutic use, Pyridinium Compounds pharmacology, Pyridinium Compounds therapeutic use, Structure-Activity Relationship, Acetylcholinesterase biosynthesis, Cholinesterase Inhibitors poisoning, Enzyme Reactivators chemical synthesis, Organophosphate Poisoning, Oximes chemical synthesis, Pyridinium Compounds chemical synthesis
Abstract

2-Hydroxyiminomethyl-4-alkylpyridine methiodides were prepared and tested for their in vitro reactivating potency on phosphorylated electric eel cholinesterase. They were also tested as in vivo protecting agents: only one of the compounds, 4-methyl-2-hydroxyiminopyridine, offered a greater protection from DFP than 2-PAM, the others had little to no effect.

Published
1978

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