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Sports injuries of the musculoskeletal system of different localization represent actual problems of modern traumatology and rehabilitation. Despite the large number of proposed methods of therapy, the question of the management of injuries in athletes remains open. The main goal is to identify effective and safe approach to drug and non-pharmacological treatment and rehabilitation of athletes, allowing them to restore damaged structures and functional capabilities of the body to the initial level in a short time, as well as reduce the risk of relapse and repeated injury of athletes of any age. This review of clinical cases demonstrates a modern approach to this problem based on recent breakthroughs in the inflammation resolution. Particular attention is paid to the role of complex bioregulatory medicines Traumeel S and Zeel T in the management of sport injuries. Four clinical cases of patients of different ages and sexes are presented for consideration, two of them had knee injury, one patient presented with acromioclavicular joint injury, and the last one was suffering from achilles tendon rupture. The treatment algorithms based on the complex bioregulatory medicines Traumeel S and Zeel T in different forms (injectables, ointment and tablet) are actively used in multidisciplinary clinic. In these settings patients can receive the necessary therapy according to clinical experience of other colleagues that was published in scientific articles. Abovementioned clinical cases demonstrate that complex bioregulatory medicines and various physiotherapeutic methods may be considered as an effective treatment option in sport injuries.