1. Genetic Evolution of a Helicobacter pylori Acid-Sensing Histidine Kinase and Gastric Disease.
- Author
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Krishna, Uma, Romero-Gallo, Judith, Suarez, Giovanni, Azah, Ayeetin, Krezel, Andrzej M., Varga, Matthew G., Forsyth, Mark H., Peek Jr., Richard M., and Peek, Richard M Jr
- Subjects
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HELICOBACTER pylori , *HISTIDINE kinases , *ACHLORHYDRIA , *GASTRITIS , *GENETIC mutation - Abstract
Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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