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1. Adaptation to Antimicrobials and Pathogenicity in Mycoplasmas: Development of Ciprofloxacin-Resistance and Evolution of Virulence in Acholeplasma laidlawii.

Author

Medvedeva ES, Mouzykantov AA, Kostenko VV, Baranova NB, Markelova MI, Sabouni RG, Khusnutdinova DR, Chernova OA, and Chernov VM

Subjects
Virulence, Anti-Bacterial Agents pharmacology, Adaptation, Physiological, Ciprofloxacin pharmacology, Drug Resistance, Bacterial, Acholeplasma laidlawii pathogenicity, Acholeplasma laidlawii drug effects, Acholeplasma laidlawii genetics
Abstract

For the first time it was shown that the development of resistance to ciprofloxacin in vitro in Acholeplasma laidlawii, a mycoplasma which is widely spread in nature and which is the main contaminant of cell cultures and vaccines, is associated with diverse pathways of virulence evolution: virulome and virulence differ significantly between ciprofloxacin-resistant strains, including those with the same level of antimicrobial resistance., (© 2021. Pleiades Publishing, Ltd.)

Published
2021
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