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FOR several years we have endeavored to follow the reported cases of the Cushing syndrome. In many instances, by correspondence with the physician, it has been possible to pursue a suspected case to verification, and to obtain sections of the pituitary gland to compare with others in the collection of the Brain Tumor Registry. Prior to this present war we received data from most of the authors of case reports save those who had been dislocated from their practices. The war and other duties have prevented us from completing a full report on this material, yet certain impressions that were gained perhaps deserve to be presented in an informal way at this time. A recently verified case of the Cushing syndrome reported by Paschkis, et al. (26) serves to illustrate the unsolved problem of this disease. The patient, Miss E. R., was a beautiful girl of 17 when the syndrome began to be active, and the first signs were the development of a moon-face, acne, a tendency to baldness, fatigability, and amenorrhea.